Effect of maternal use of flaxseed oil during pregnancy and lactation on glucose metabolism and pancreas histomorphometry of male offspring from diabetic rats

Correia-Santos, André Manoel; Suzuki, Akemi; Vicente, Gabriela Câmara; Anjos, Juliana Saraiva dos; Pereira, Aline D'Avila; Lenzi-Almeida, Kátia Calvi; Boaventura, Gilson Teles

doi:10.1016/j.diabres.2014.09.022

Cited by 8 publications

(10 citation statements)

References 38 publications

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“…Consumption of a diet rich in saturated fatty acids was associated with the development of hepatic steatosis with a higher degree of hepatic impairment, unlike a diet rich in polyunsaturated fatty acids [14]. The excess of saturated fatty acids resulted in altered endocrine pancreas morphometry with lower density of insulin-containing islets, which was not observed in offspring of rats that received the flaxseed high fat diet [3].…”

Section: Introductionmentioning

confidence: 95%

“…Consumption of high fat diets in pregnancy and lactation is associated with cardiometabolic diseases in adulthood [1,2]. Fat content in high fat diets varies among experimental studies, reaching 65% of Total Energy Value (TEV) fat in some diets [1,3,4]. High fat rodent diets can be classified into: high lipid diets with 30% to 50% TEV and very high lipid diets with over 50% TEV [5]; such values are well above those recommended by the American Institute of Nutrition (AIN), which advocates the supply of 7% lipids in the concentration of the soybean-based experimental diet, which corresponds to 17% TEV, as safe for meeting the needs of essential fatty acids.…”

Section: Introductionmentioning

confidence: 99%

“…Nutritional manipulation with high fat diets during the critical period may imply morphological and functional changes in organs important for endocrine regulation with risk for the development of metabolic diseases in adulthood [3,4,14]. The increased nutritional demands of rodents regarding macronutrients (carbohydrates, proteins and lipids) and micronutrients (vitamins and minerals) during pregnancy, lactation and growth [6,7] sometimes is not considered in the elaboration of experimental diets or in the supply of food to animals by their breeders, especially when using commercial feed and this fact can lead to potential deficiencies.…”

Section: Introductionmentioning

confidence: 99%

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Composition of a maternal high fat diet rich in satured fats and omega 3 in gestation and lactation for studies with rodents

et al. 2019

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Objective To prepare a high fat diet rich in satured fatty acids and supplemented with omega 3 for experimental studies in rodents. Methods Purified industrial ingredients and flaxseed oil as a source of omega 3 at a concentration of 3.5% (v/w) were used in the elaboration of the diets. Centesimal and nutritional compositions, fatty acids profile and dietary intake were evaluated. Serum levels of total protein, albumin, cholesterol and glucose in pregnant rats were verified. The offspring were assessed with regard to body mass and waist circumference. Statistical analysis was performed using the Kolmogorov-Smirnov, Anova One-Way test and Bonferroni post-test. Results High fat and high fat with omega 3 diets presented, respectively, 37% and 36% saturated fat, and the lipid amount was 80% higher than the American Institute of Nutrition 93G control diet. The omega 3 content was 50% higher in the high fat with omega 3 diet. There was no difference in consumption of diet types in weight (grams). The dams that received the High fat diet developed hypercholesterolemia and their High fat offspring exhibited higher body mass on the 1st day of life and increased abdominal circumference on the 30th day of life compared to the control and the high fat with omega 3 offspring. Conclusion The formulated diets with a higher amount of saturated fatty acids meet the nutritional requirements of the gestation and lactation period. The high fat diet with omega 3 was able to attenuate the changes observed in dams and their offspring.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Composition of a maternal high fat diet rich in satured fats and omega 3 in gestation and lactation for studies with rodents

et al. 2019

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“…In animal models, maternal supplementation with flaxseed oil resulted in normal pancreas histomorphometry and β-cell mass in both female [86] and male offspring [87], while treatment of diabetic mothers with flaxseed flour reversed offspring low birth weight [88]. Supplementation with ω-3 fatty acids from flaxseed oil in combination with vitamin E in women with gestational diabetes resulted in a reduction of all parameters of glucose homeostasis: glucose and insulin levels, as well as values for the homeostasis model of assessment-estimated insulin resistance (HOMA-IR), in addition to serum triglycerides, very low density cholesterol (VLDL) and HDL concentrations [89], followed by increment of total antioxidant capacity and decrement of plasma malondialdehyde (MDA) concentrations, as well as lower incidences of hyperbilirubinemia in newborns [90].…”

Section: Echinacea Sp Echinacea Angustifolia DCmentioning

confidence: 99%

Herbal Therapy in Pregnancy-What to Expect when you Expect?

Belica

Ćetković

Milić

et al. 2017

Natural Product Communications

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The use of herbal therapy in pregnancy is common for pregnancy related nausea, vomiting, gestational diabetes, anxiety, insomnia, and preparation for labor, as well as for treating infections. Many conventional drugs may interfere with fetal development and herbal products are considered to be safe. However, herbal therapy requires competent healthcare professional advice before prescribing. Knowledge about the possible adverse effects of active compounds of the herbs on pregnancy outcome is limited. Interference of herbal ingredients with conventional medication or the ailment should also not be excluded. For many herbal products, the pharmacological effect is not clinically proven, and the safe usage in pregnancy is not guaranteed. Here, based on published clinical trials, an overview is given of the efficacy and safety for fetal development and pregnancy outcome of the most frequently used herbs: ginger, cranberry, echinacea, mint, chamomile, valerian, flaxseed, tea and raspberry leaf.

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“…The antioxidant ability of lignans, tocopherols and flavanoids is related to the presence of OH groups which may directly bind to free radicals and chelate metals (Pengkumsri et al, 2015). Flaxseed oil is cited as potentially useful by the American Heart Association in the prevention of cardiovascular diseases, including reduction of serum cholesterol, platelet aggregation, and inflammatory markers, improving glucose tolerance and acting as an antioxidant (Santos et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of seed maturation stages on physical properties and antioxidant activity in flaxseed ( Linum usitatissimum L.)

Herchi

Bahashwan

Trabelsi³

et al. 2015

Food Sci. Technol

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The changes in flaxseed constituents at different stages of maturity are reported. The physical properties and antioxidant activity of flaxseed oil during flaxseed development have been evaluated. Continuous decrease in total polyphenol content during flaxseed development. All the results showed no significant differences between HPLC-MS and TLC for quantitative determination of phospholipids classes. The fatty acid compositions of individual phospholipids were also reported. The antioxidant activity of oilseed was assessed by means of 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging assay. The test demonstrated that the antioxidant activity of the flaxseed oil was found to be harvesting time-dependant. Keywords: physical properties; antioxidant activity; total polyphenol content; flaxseed oil; HPLC-MS; maturation.Practical Application: Practical application for the study entitled '' Effect of seed maturation stages on physical properties and antioxidant activity in flaxseed (Linum usitatissimum L.)" regard the possibility of analyzing phospholipids contents and antioxidant activity during flaxseed development. The changes in the constituents of flaxseed during development and maturity have been a subject of continuing interest for many investigators. From this study, valuable information will be provided for flaxseed cultivations and help in developing functional food resources.

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Effect of maternal use of flaxseed oil during pregnancy and lactation on glucose metabolism and pancreas histomorphometry of male offspring from diabetic rats

Cited by 8 publications

References 38 publications

Composition of a maternal high fat diet rich in satured fats and omega 3 in gestation and lactation for studies with rodents

Composition of a maternal high fat diet rich in satured fats and omega 3 in gestation and lactation for studies with rodents

Herbal Therapy in Pregnancy-What to Expect when you Expect?

Effect of seed maturation stages on physical properties and antioxidant activity in flaxseed ( Linum usitatissimum L.)

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