Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis

Ye, Hui; He, Yazhou; Wang, Jiarong; Song, Tiange; Zhu, Li; Zhao, Yiqi; Xi, Mingrong

doi:10.1007/s12041-016-0675-5

Cited by 25 publications

(16 citation statements)

References 40 publications

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“…In recent years, research on correlation of autophagy and tumor has become a hot spot, and studies have shown that the autophagy capacity varies in a variety of tumors. EM possesses many biological characteristics of tumor diseases, such as metastasis, implantation and recurrence (18,19). It has been reported that autophagy is related to various malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis

Sui

Sun

et al. 2018

Exp Ther Med

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Expression of autophagy-related proteins, microtubule-associated protein light chain 3 (LC3) and Beclin1, and matrix metalloproteinase-2 (MMP-2) was investigated in serum and peritoneal fluid of patients with endometriosis (EM). The messenger ribonucleic acid (mRNA) expression levels of MMP-2, LC3 and Beclin1 in endometrial tissues of EM patients and correlation of these genes with EM and their significance were evaluated. The serum, peritoneal fluid and endometrial tissues of 84 patients treated in The First Affiliated Hospital of Qiqihar Medical University (Qiqihar, China) from March 2016 to March 2017 were collected. The serum, peritoneal fluid and endometrial tissues of 42 EM patients were used as the experimental group, while those of 42 non-EM patients were used as the control group. The levels of LC3, Beclin1 and MMP-2 in serum and peritoneal fluid of EM patients and non-EM patients were quantitatively detected via enzyme-linked immunosorbent assay (ELISA), followed by comparative analysis based on data in both groups. In addition, mRNA expression of LC3, Beclin1 and MMP-2 in the endometrium in both groups were detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and differences in expression of these genes between the groups were analyzed and evaluated. Correlation of LC3, Beclin1 and MMP-2 with EM was explored. Results of ELISA showed that levels of LC3 and Beclin1 in the EM group were significantly lower than those in the control group, while levels of MMP-2 in serum and peritoneal fluid of the EM group were significantly higher than those in the control group (P<0.05). Results of RT-qPCR revealed that mRNA expression of LC3 and Beclin1 in the endometrium of patients in the EM group were obviously decreased compared with those in the control group, while the expression of MMP-2 was high, and differences in expression were statistically significant (P<0.05). The expression of MMP-2 is high, and expression of LC3 and Beclin1 is low in serum, peritoneal fluid and endometrium of EM patients, and investigating the expression of MMP-2, LC3 and Beclin1 in EM is helpful to further clarify the pathogenesis of EM, and guide the clinical diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis

Sui

Sun

et al. 2018

Exp Ther Med

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“…The many observations in women with endometriosis can be interpreted as the expression of predisposition and/or as the consequence of endometriosis instead of being the cause. These comprise abundant retrograde menstruation (194) and the recent observations on cellular pathways (195), cytokines (196)(197)(198)(199), dentritic cells (200), vitamin D (201), mast cells (202,203), hypoxia-inducible factor (204), high Mobility Group Box-1 and Toll-Like Receptor 4 (205), matrix metalloproteinase promoter polymorphisms (206), galectin-3 expression (207), promoter polymorphisms of matrix metalloproteinase genes (208), P receptor (PR) expression (209), acylcarnitines, phosphatidylcholines, and sphingomyelins in PF (210), uterine leukocytes (96), vascular epithelial growth factor (211,212), and other angiogenic factors (213) such as the TGF-b superfamily (214), vezatin expression (215), lymphocytes in blood (216), prostaglandins (217), insulin-like growth factor I (IGF-I) (218), repeated micro-trauma (219) or macro-trauma (63), transcription-3 signaling (220), genetic variants expression (221), and the Hoxa10/HOXA10 gene (222).…”

Section: Figurementioning

confidence: 99%

Pathogenesis of deep endometriosis

Gordts

Koninckx²,

Brosens

2017

Fertility and Sterility

187

115

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“…Recently a few metaanalysises were published, summarizing those results. Two of them emphasize MMP-1 1607 1G/2G polymorphism in predicting endometriosis risk ( 105 , 106 ). Nevertheless, no such correlation was found for MMP-2 15918 T/C (rs243847), MMP-2 −735 C/T (rs2285053), MMP-3 −1171 5A/6A, MMP-7 −181 A/G (rs11568818), MMP-9 −1562 C/T (rs3918242) and MMP-9 R279Q (rs17576) polymorphisms and endometriosis ( 107 ).…”

Section: Polymorphism Of Mmps Genes In Endometriosismentioning

confidence: 99%

The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)

2018

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Aberrant regulation of matrix metalloproteinases (MMPs) may be the primary cause of endometrial lesion formation in a group of predisposed women. Prospect for the genuine origin of endometriosis is ongoing, since retrograde menstruation leads to presence of endometrial debris in peritoneal cavity of many women, which do not experience endometriosis. Tissue remodeling is regulated precisely by a balance of MMPs and their inhibitors. Interplay between factors enhancing and suppressing matrix turnover is crucial for cyclic preparation of endometrium for embryo implantation, and endometrial shedding and renewal in physiology of primates. Disorders of the regulation of matrix remodeling leads to augmentation of implantation and invasive growth of ectopic endometrial tissue. Moreover, endometriosis-induced changes in the matrix balance leads to adhesion formation, ovulatory dysfunction and fertility impairment. The review summarizes the current knowledge regarding the regulation of extracellular matrix turnover in the physiology of the endometrial cycle and in the development of endometriosis, as well as the pathophysiology of ovulatory dysfunction in endometriotic women. Therapeutic modalities utilizing modulation of tissue remodeling were discussed.

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Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis

Cited by 25 publications

References 40 publications

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis

Pathogenesis of deep endometriosis

The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)

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