Effect of Mechanical Perfusion on Ischemia-reperfusion Injury after Liver Transplantation

Abstract

Ischemia-reperfusion injury is one of the main factors of organ loss after liver transplantation. The occurrence of this complication is affected by acidosis, oxygen free radical explosion, inflammatory changes and other factors, and this complication is also the focus of research in the field of organ transplantation. The most ancient method of donor liver preservation is static cold preservation, but this method can not effectively meet the needs of the development of organ transplantation. With the development of mechanical perfusion technology, its research in donor liver preservation has gradually increased and matured, which is expected to become the main technology for donor liver repair and preservation in the future. Combined with existing animal studies, mechanical perfusion has a prominent effect on saving marginal donor liver, which is helpful to control ischemia-reperfusion injury after liver transplantation and promote the improvement of postoperative liver function. In recent years, some developed countries have applied mechanical perfusion technology in clinical diagnosis and treatment, and achieved certain results, but there are relatively few clinical data at the present stage. Based on the development background of mechanical perfusion technology and the principle of mechanical perfusion technology, this paper analyzed the influence of mechanical perfusion on ischemia-reperfusion injury after liver transplantation based on the relevant literature in recent years.