Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis

Nakagawa, Shoichi; Nakaishi, Mayumi; Hashimoto, Motomu; Ito, Hiromu; Yamamoto, Wataru; Nakashima, Ran; Tanaka, Masao; Fujii, Tomoyuki; Omura, Tomohiro; Imai, Shoichi; Yonezawa, Atsushi; Imai, Hirohisa; Mimori, Tsuneyo; Matsubara, Kazuo

doi:10.1371/journal.pone.0206943

Cited by 18 publications

(12 citation statements)

References 28 publications

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“…Accordingly, it was determined that as the continuity of care and the treatment adherence increased, the functionality increased, and as the disease activity increased, the functionality decreased. Similarly, studies conducted by Ragab et al, 70 Pascual-Ramos et al, 71 and Nakagawa et al, 72 it was found that functionality increased as the treatment adherence increased. Studies conducted by Drossaers-Bakker et al, 73 Sokka et al, 74 Boyd et al, 75 Nikiphorou et al, 76 and Kamel et al 77 it was determined that there was a negative relationship between the disease activity and the functionality.…”

Section: Discussionmentioning

confidence: 59%

Serial multiple mediation of treatment adherence and disease activity in the relationship between continuity of care and health outcomes among rheumatoid arthritis patients

İlgün

ŞAHİN

2022

Health Planning & Management

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Objective To evaluate the effect of continuity of care on health outcomes (quality of life and functionality) in patients with rheumatoid arthritis and to reveal whether treatment adherence and disease activity have a serial multiple mediator role on this relationship. Methods The study was cross‐sectional on 440 rheumatoid arthritis patients who applied to a university hospital rheumatology outpatient clinic. Research data were obtained from both the questionnaire method, which is the primary data source, and the patient files, which are the secondary data source. Process analysis was used in the analysis of the data. Results It was found that the continuity of care has a direct effect on the quality of life and the functionality. In addition, it is seen that treatment adherence has a single partial mediator role on the relationship between continuity of care and quality of life; It has been determined that treatment adherence and disease activity have both partial single mediation and serial multiple mediation roles on the relationship between continuity of care and functionality. Conclusion It is thought that these findings will provide clinicians with important data and information in the management of rheumatoid arthritis.

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Section: Discussionmentioning

confidence: 59%

Serial multiple mediation of treatment adherence and disease activity in the relationship between continuity of care and health outcomes among rheumatoid arthritis patients

İlgün

ŞAHİN

2022

Health Planning & Management

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“…В одній із недавніх робіт S. Nakagawa та співавт. [11] показали, що хворі з високою прихильністю мають значно нижчу активність ПсА, проте ця закономірність поширюється тільки на пацієнтів з три-валістю ПсА до 4,6 років. За більшої тривалості захворювання такої залежності не відзначається.…”

Section: результати дослідження та їх обговоренняunclassified

Adherence to Treatment and Psycho-Emotional Status in Patients With Psoriatic Arthritis and Comorbidity

Ishcheykina¹,

Tkachenko²,

Babanina³

et al. 2022

Act. Probl. of the Modern Med.

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At the current stage of medical science, the effectiveness of treatment depends not only on the professionalism of physicians, but also on the responsibility of the patients themselves. Low adherence has been proven to be a significant cause of the reduced therapy effectiveness and quality of life, increased risk of complications and treatment costs, worsening of disease prognosis, and reduced patient life expectancy. According to WHO reports, more than 250 factors can influence the adherence to the treatment. Until now, no "gold standard" has been developed for the assessment of adherence to treatment. Patients with psoriasis typically face social stigmatization and rejection, with subsequent profound effects on self-confidence, self-esteem, and feeling of psycho-emotional discomfort. Comorbidity of arthritis affects the psycho-emotional status of patients even more seriously. The purpose of the study is to analyze the psycho-emotional state, adherence to treatment, medical support and recommendations for lifestyle modification in patients with erosive form of psoriatic arthritis comorbidity. 60 patients with a reliable diagnosis of psoriatic arthritis and comorbid pathology were included in the study. Patients with psoriatic arthritis and comorbidity had mainly an average level of adherence to medication, medical support, and a low level of adherence to recommendations for lifestyle modifications. Taking oral glucocorticosteroids was associated with high adherence to drug therapy, while low adherence to medical care was associated with psychoemotional disorders such as anxiety and depression.

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“…According to several studies in RA patients, higher medication adherence is statistically significant associated with lower flare rate and disease activity score (DAS-28). [4,5] Effective disease control at an early stage can also prevent irreversible joint damage and hence improve patients' quality of life. [4] Study data also supported that drug counseling and education has the highest evidence in improving medication adherence.…”

Section: According To a Study Conducted By Census And Statisticsmentioning

confidence: 99%

“…[4,5] Effective disease control at an early stage can also prevent irreversible joint damage and hence improve patients' quality of life. [4] Study data also supported that drug counseling and education has the highest evidence in improving medication adherence. [6] Pharmacists who are the experts in drugs are capable of providing counseling to arthritis patients, improving their drug adherence and disease activities.…”

Section: According To a Study Conducted By Census And Statisticsmentioning

confidence: 99%

The Role and Responsibility of Clinical Pharmacists in Rheumatology Clinic: An exploratory study in Hong Kong

Yip

Chong

2020

APJHM

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In Hong Kong, arthritis is the third leading chronic disorder among the older people. It could create a huge amount of burden on the health care system if patients cannot achieve good diseases control and have recurrent flare up of diseases. To maintain stable control and minimize acute flare up, medication adherence is essential. Studies revealed that drug education has the highest evidence in improving medication adherence. Pharmacists who are expert in drugs can provide counseling to arthritis patients, improving their drug adherence and disease activities. As a result, research evaluating the effectiveness of pharmacist counseling service on improving arthritis patients’ medication adherence and disease activities in Hong Kong has been initiated in a specialist out-patient clinic of a local acute hospital. This research aims to improve patient medication adherence and enhance medication safety. A validated Compliance Questionnaire on Rheumatology (CQR-19) is used to measure the medication adherence. From the preliminary data, over 90% of the recruited subjects are non-adherence at baseline and thus, detailed drug counseling is necessary. During the first visit, pharmacists will provide a 20 minutes drug counseling service to the referred patients. This includes discussion on drug administration schedule, importance of drug adherence, side effects management and pain management. Besides, pharmacists also have different roles in other aspects such as drug information and procurement. Pharmacists would assist in providing evidence-based information and recommendations to physicians and nurses for drug-related enquiries. These attempts to improve therapeutic outcomes and minimize medication errors, enhance medication safety and reduce hospitalization. Design of the multidisciplinary care model and results of this study would provide a reference for the future development of clinical pharmacist service in rheumatology.

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Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis

Cited by 18 publications

References 28 publications

Serial multiple mediation of treatment adherence and disease activity in the relationship between continuity of care and health outcomes among rheumatoid arthritis patients

Serial multiple mediation of treatment adherence and disease activity in the relationship between continuity of care and health outcomes among rheumatoid arthritis patients

Adherence to Treatment and Psycho-Emotional Status in Patients With Psoriatic Arthritis and Comorbidity

The Role and Responsibility of Clinical Pharmacists in Rheumatology Clinic: An exploratory study in Hong Kong

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