Effect of Medium-chain Triglycerides on the Postprandial Triglyceride Concentration in Healthy Men

Kasai, Michio; Maki, Hideshi; Nosaka, Naohisa; Aoyama, Toyohiko; Ooyama, Katsuhiko; Uto, H.; Okazaki, Mitsuko; Igarashi, Osamu; Kondo, Kazuo

doi:10.1271/bbb.67.46

Cited by 46 publications

(20 citation statements)

References 34 publications

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“…In the present study, similar effects on body composition were obtained with one-half of the MCT intake (5 g instead of 10 g) compared with two previous studies. On the other hand, we reported previously that the postprandial triglyceride level in the subjects with BMI ≥ 23 kg/m 2 after ingestion of 10 g of MCT was significantly less than LCTs (24). Many investigators indicated that visceral fat accumulation was associated with dyslipidemia and atherosclerosis (4-6).…”

Section: Discussionmentioning

confidence: 89%

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Nosaka

Maki

Suzuki

et al. 2003

JAT

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We found previously that the ingestion of margarine containing medium-chain triacylglycerols (MCT) resulted in a significant increase in postprandial thermogenesis when compared with long-chain triacylglycerols (LCT). Diets that included margarine containing MCT and LCT were compared for 12 weeks in 73 subjects to investigate the effects on body weight, body fat, areas of subcutaneous and visceral fat, serum total cholesterols, triglycerides, lipoproteins, plasma glucose, serum insulin, total ketone bodies, and the activities of aspartate aminotransferase, alanine aminotransferase, and γ-glutamyltranspeptidase. We conducted a double-blind, controlled study and used blended rapeseed oil and soybean oil (LCT) as a comparison. Two groups ingested 2,100-2,400 kcal/day of energy, 65-73 g/day of total fat, and 14 g/day of test margarine (5 g/day of MCT or LCT). The subjects on the MCT diet demonstrated significant decreases in body fat weight (-3.8 ± 2.4 kg vs -2.4 ± 1.7 kg; MCT vs LCT, mean ± SD), subcutaneous fat (-38.2 ± 29.9 cm 2 vs -22.6 ± 19.3 cm 2 ), and visceral fat (-12.2 ± 11.2 cm 2 vs -1.6 ± 12.8 cm 2 ) after 12 weeks. There were no clinical differences in measured blood parameters. We suggest that the postprandial increase in thermogenesis and control of postprandial triglyceride levels may explain these results. J Atheroscler Thromb, 2003; 10: 290-298.

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Section: Discussionmentioning

confidence: 89%

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Nosaka

Maki

Suzuki

et al. 2003

JAT

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“…MCT had reducing effects not only on postprandial TG but also on fasting TG levels in humans. In 25 male subjects with BMIX23 kg/m 2 , the intake of 10 g MCT induced lower postprandial TG as compared with the intake of 10 g LCT (Kasai et al, 2003a). In another double-blind crossover study, the subjects ingested a liquid diet containing 20 g/d of MLCT or soybean oil in addition to their regular diets.…”

Section: Discussionmentioning

confidence: 99%

Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects

et al. 2009

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Objectives: To investigate the effects of medium-and long-chain triacylglycerol (MLCT) on blood triglyceride (TG) in Chinese hypertriglyceridemic subjects. Methods: A double-blind controlled clinical trial was carried out, in which 112 subjects with hypertriglyceridemia were randomly divided into two dietary oil groups: (1) long-chain triacylglycerol (LCT) and (2) MLCT. All subjects were requested to ingest fixed energy and to continue their normal activity levels, and to consume LCT or MLCT oil at 25-30 g daily during the study period. Anthropometric measurements of body weight, body mass index (BMI), body fat, body fat percentage, waist and hip circumference (WC and HC), areas of subcutaneous and visceral fat by computed tomography scanning and blood biochemical markers were measured at the beginning and end of the study. Results: There were 50 and 51 subjects left in LCT and MLCT groups, respectively. There were no significant differences in daily intake of energy, protein, fat and carbohydrate, as well as the daily physical activity between the two groups during the study. After 8 weeks, MLCT group showed a significant decrease in body weight, BMI, WC, HC, ratio of WC and HC, body fat, body fat percentage and subcutaneous fat when compared with the initial values. The decrease in body weight, BMI, WC, body fat and subcutaneous and visceral fat was significantly greater in MLCT group than that in the LCT group. Furthermore, the serum concentrations of TG in MLCT group were significantly lower than those in the LCT group. Conclusions: Consumption of MLCT may reduce body weight, body fat and blood TG in hypertriglyceridemic subjects under an appropriate dietary regime.

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“…14,[17][18][19][20] On the contrary, some have reported a positive role of MCFAs in lowering blood TG. 8,21) We have reported that MLCT reduced blood TG in Chinese hypertriglycerideamic subjects. 22) These different results might be attributed to the different subjects chosen.…”

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confidence: 94%

Chinese Hypertriglycerideamic Subjects of Different Ages Responded Differently to Consuming Oil with Medium- and Long-Chain Fatty Acids

Xue

Liu

Wang

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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Effect of Medium-chain Triglycerides on the Postprandial Triglyceride Concentration in Healthy Men

Cited by 46 publications

References 34 publications

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans

Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects

Chinese Hypertriglycerideamic Subjects of Different Ages Responded Differently to Consuming Oil with Medium- and Long-Chain Fatty Acids

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