Effect of MEF2A and SLC22A3-LPAL2-LPA gene polymorphisms on warfarin sensitivity and responsiveness in Jordanian cardiovascular patients

Abstract

Aims This study aims to investigate the influence of MEF2A and SLC22A3-LPAL2-LPA polymorphisms on cardiovascular disease susceptibility and responsiveness to warfarin medication in Jordanian patients, during the initiation and maintenance phases of treatment. Backgrounds Several candidate genes have been reported to be involved in warfarin metabolism and studying such genes may help in finding an accurate way to determine the needed warfarin dose to lower the risk of adverse drug effects, resulting in more safe anticoagulant therapy. Methods The study population included 212 cardiovascular patients and 213 healthy controls. Genotyping of MEF2A and SLC22A3-LPAL2-LPA polymorphisms was conducted to examine their effects on warfarin efficiency and cardiovascular disease susceptibility using PCR-based methods. Results One SNP (SLC22A3-LPAL2-LPA rs10455872) has been associated with cardiovascular disease in the Jordanian population, whereas the other SNPs in the MEF2A gene and SLC22A3-LPAL2-LPA gene cluster did not have any significant differences between cardiovascular patients and healthy individuals. Moreover, SLC22A3-LPAL2-LPA rs10455872 was correlated with moderate warfarin sensitivity, the other SNPs examined in the current study have not shown any significant associations with warfarin sensitivity and responsiveness. Conclusion Our data refer to a lack of correlation between the MEF2A polymorphism and the efficacy of warfarin treatment in both phases of treatment, the initiation, and maintenance phases. However, only rs10455872 SNP was associated with sensitivity to warfarin during the initiation phase. Furthermore, rs3125050 has been found to be associated with the international normalized number treatment outcomes in the maintenance phase.

PTPRD gene variant rs10739150: A potential game-changer in hypertension diagnosis

“…In conclusion, our data imply that only the rs10739150 genotype of the PTPRD gene shows an increased risk of hypertension, and the G allele is strongly related to the disease development. Considering the paucity of studies concerning pharmacogenetics and personalized medicine in Jordan [ 52 – 54 ], larger sample sizes and family-based analyses are needed to understand the biochemical processes and mechanisms by which this genetic variation impacts hypertension susceptibility, as well as to assess the implications on drug responsiveness. Our study is the first of its kind that uses Jordanian Arab descendants, thus raising the question of the effect of genetic polymorphisms and ethnicity on hypertension risk.…”

ACE gene polymorphism and susceptibility to hypertension in a Jordanian adult population

“…Numerous gene families have been implicated in cardiovascular diseases, with multiple genetic variations spread across the Jordanian population. Research has also indicated that several SNPs may also influence the response to cardiovascular medications such as warfarin [35][36][37][38][39][40][41][42][43][44]. However, the relationship between polymorphism within the ACE gene and HTN is still debatable and has so far been inconclusive; the reason is ethnic variations and geographic features.…”