Effect of Meglumine Iothalamate on Renal Hemodynamics and Function in the Diabetic Rat

Leeming, B. W. A.; Spokes, Katherine; Silva, Patricio

doi:10.1097/00004424-198512000-00015

Cited by 20 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The limited research documenting contrast agent induced hemodynamic alterations in the in vivo animal or human models have involved models requiring multiple insults such as diabetes, salt depletion, uninephrectomy, and indomethacin to produce chronic decreases in GFR after contrast agent exposure (Heyman et al , 1988(Heyman et al , 1992Leeming et al 1985). Although we could not document direct tubular toxicity following diatrizoate exposure, this agent appears to induce an acute decrease in GFR in the mouse.…”

Section: Discussionmentioning

confidence: 57%

“…Hemodynamic alterations have been observed after contrast media exposure. Decreases in renal blood flow have been documented with the suggestion that these changes may induce acute renal failure (Brown et al 1992;Cunningham et al 1986;Leeming et al 1985;Nygren et al 1988). However, a number of in vivo models have required a combination of contrast media, uninephrectomy, prostaglandin inhibitors, and volume depletion to induce renal failure Heyman et al 1988;Vari et al 1988).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney

Morgunov¹,

Foster²,

Hirsch³

1997

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

The isolated perfused mouse proximal tubule was used to examine electrophysiologic effects of diatrizoate and ioversol. Luminal or basolateral application of diatrizoate resulted in a dose-dependent, reversible hyperpolarization of the proximal tubule cell basolateral membrane potential (VB), which could be abolished by the addition of 10 microM probenecid. While there was a modest reduction in intracellular ATP following a 60-min exposure to diatrizoate, there was no deterioration of VB after 90 min of diatrizoate exposure, even following a 20-min hypoxic insult. Ioversol did not elicit an electrical response. Neither diatrizoate nor ioversol significantly affected transepithelial potential (VT) in the isolated perfused medullary thick ascending limb. In vivo studies showed that only the ionic contrast agent diatrizoate significantly reduced glomerular filtration rate, by 70%. The observed acute contrast media induced reduction in glomerular filtration rate does not appear to depend on direct renal tubular cytotoxicity.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney

Morgunov¹,

Foster²,

Hirsch³

1997

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…However, other previous results indicate that the adverse effect of CM on the serum creatinine (38), as well as on the glomerular filtration rate (GFR) (23), is potentiated by experimentally induced diabetes. This occurred in rats after large doses of CM (2.6 g I1kg b.w.)…”

Section: Discussionmentioning

confidence: 98%

“…(36). LEEMING et al (23) used 1.8 mg I1kg b.w. and found a sustained decrease of GFR after CM infusions in rats with long-standing diabetes (6 months).…”

Section: Discussionmentioning

confidence: 99%

In Vivo Fluorescence Microscopy of Microcirculation in the Renal Cortex of Mice

Högström¹,

Hietala²,

Rooth³

1994

Acta Radiol

View full text Add to dashboard Cite

In vivo f1uorescence microscopy was used in experimental studies of renal cortical microcirculation in mice. The effects of i.v. infusions of mannitol and iohexol were studied in normal and obese/hyperglycemic mice and in mice with streptozotocin-induced diabetes mellitus. All infusions produced marked effects on the distribution and velocity of cortical blood flow with no differences between iohexol and mannitol. The renal cortical blood flow was inhomogeneous regarding different capillaries and there was an initial rise in the number of capillaries with increased blood flow after infusions of both mannitol and iohexol. The infusions of contrast medium were initially followed by a significantly larger number of capillaries with decreased blood flow in the obese/hyperglycemic mice (p < 0.05) than in the diabetic and nondiabetic mice. The variations in obese/hyperglycemic groups were, however, large. The effects were the same in normal and diabetic animals.

show abstract

“…Rather than an exaggerated risk of nephrotoxicity, induced-diabetic rats are protected from nephrotoxic doses of gentamicin, mercury and contrast media. Others (9) have found that the kidneys of diabetic animals have an abnormal hemodynamic response to contrast media that may increase the susceptibility to injury.…”

mentioning

confidence: 99%

Microangiography — A Sensitive Method for Studying Experimental Diabetic Nephropathy

Merikanto

Hietala²,

Lithner³

et al. 1993

Acta Radiol

View full text Add to dashboard Cite

Microangiographic and conventional histopathologic investigations of the kidney were compared in 15 alloxan diabetic and 7 nondiabetic control rats. Contrary to the relatively sparse histologic lesions, microangiography disclosed advanced vascular abnormalities, including arteriolar aneurysms, which increased with the duration of diabetes. It is concluded that microangiography is a sensitive and suitable method for studying the development of microvascular lesions of the kidney in experimental diabetes.

show abstract

Effect of Meglumine Iothalamate on Renal Hemodynamics and Function in the Diabetic Rat

Cited by 20 publications

References 0 publications

Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney

Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney

In Vivo Fluorescence Microscopy of Microcirculation in the Renal Cortex of Mice

Microangiography — A Sensitive Method for Studying Experimental Diabetic Nephropathy

Contact Info

Product

Resources

About