Effect of Melamine Adulteration on Body Weight, Liver and Kidney Histology and Liver Function Indices of Albino Rats

Abstract

The effect of melamine adulteration on body weight, liver and kidney histology and liver function using feed containing 0, 4, 8, 12 and 16 mg of melamine per kg diet administered ad labium to wistar rats were studied. Kidney histology was affected at concentrations $8 mg kgG 1 by the onset of mild interstitial chronic inflammation while the liver histology of all test animals appeared normal. Results of body weight change showed significant (p<0.05) increase at the highest dosed group though, body weight increase was observed in all animals. The subchronic toxicity study on liver function parameters showed significant (p<0.05) increase in ALT activity at all doses while, total protein concentration was significantly affected (p<0.05) in the highest dosed group. Melamine should therefore, be absent from feed especially at concentrations approaching milligram quantity in order to safe guard health.

Potential Ameliorative Effect of Bee Honey on Experimentally Induced Melamine Formaldehyde Toxicity in Male Rats.

“…The histopathological changes in the most of examined vital assets (liver, kidney, heart, intestine and lungs) was melamine concentrations dependent, as the severity of the alterations was increased by increasing the concentration of melamine. These results controversy with those of Shehu et al (2015) who showed no histopathological changes in melamine treated male albino rats at 28 days, this may be because of the variation in exposure period of melamine toxicity. However, the bee's honey treated animals revealed some pathological changes than the only melamine treated animals and this finding matched with the result of Wilson et al (2011) who ascribed the protective rule of bee's honey on liver of adult Wister rats.…”