Effect of melatonin administration on thyroid hormones, cortisol and expression profile of heat shock proteins in goats (Capra hircus) exposed to heat stress

Sharma, Sanjeev; Ramesh, K.; Hyder, Iqbal; Uniyal, Shweta; Yadav, V.P.; Panda, Rudra Prasanna; Maurya, V. P.; Singh, Gyanendra; Kumar, Puneet; Mitra, Abhijit; Sarkar, Mihir

doi:10.1016/j.smallrumres.2012.12.008

Cited by 80 publications

(56 citation statements)

References 49 publications

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“…plasma cortisol levels, but acute exposure to high temperatures (in the range of 40°C as observed during summer in the present experiments) increases plasma cortisol levels and triggers other stress responses such as the expression of HSP in PBMC (Dangi et al, 2012;Sharma et al, 2013). These non-linear effects of increased temperature on HPA axis activity can explain apparently divergent experimental results of the effects of seasons, depending on the range of temperatures encountered at each experimental location.…”

Section: Adaptation To Heat Reducesmentioning

confidence: 57%

“…Melatonin takes part in the regulation of circadian rhythms (Pevet and Challet, 2011) and exerts direct inhibitory actions on adrenal responses to ACTH in sheep (Torres-Farfan et al, 2008). In goats, melatonin was shown to inhibit heat stress responses, including plasma cortisol increase and expression of heat-shock proteins (HSP) in peripheral blood mononuclear cells (PBMC) (Sharma et al, 2013), as well as the cortisol response to weaning stress (Redondo et al, 2010). More studies will be necessary to know the range of fluctuation of melatonin levels in our experimental conditions and explore its possible influence on HPA axis activity.…”

Section: Discussionmentioning

confidence: 99%

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Seasonal effects on plasma cortisol concentrations in the Bedouin buck: circadian studies and response to ACTH

Chergui¹,

Mormède²,

Foury³

et al. 2017

Animal

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Our work aims at the exploration of cortisol secretion in the Bedouin goat, native to the Algerian Sahara desert, to understand the mechanisms of adaptation to extreme hot climates. In the present study, diurnal and seasonal variations of cortisol concentrations were measured in basal conditions, as well as the response to ACTH stimulation tests across seasons in bucks. The plasma concentrations of cortisol showed no diurnal cycle but a large variation across seasons. The highest levels occurred in summer and winter when the environmental conditions are at their extreme levels. The rectal temperature showed nychthemeral and seasonal variations, and BW was also different across seasons with highest values in summer and lowest in winter. The results obtained after administration of two doses (2 or 10 μg/kg BW) of synthetic ACTH to three different age groups (kids, adults and elderly animals) showed a strong increase in plasma cortisol concentrations under all conditions with maximum levels achieved between 15 and 120 min. The analysis of the area under the cortisol curve showed no significant difference between the responses to the two doses of ACTH and between age groups, but showed seasonal variations with the lowest response in autumn than in other seasons. We conclude that season significantly affects secretion of cortisol in both basal state and under ACTH stimulation. However, the variation of adrenal reactivity to ACTH is not sufficient to explain seasonal differences, and in particular the summer peak in basal circulating cortisol concentrations. Further research should focus on the respective contribution of environmental factors (such as day length, temperature, humidity) and the mechanisms involved in cortisol regulation.

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Section: Adaptation To Heat Reducesmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Seasonal effects on plasma cortisol concentrations in the Bedouin buck: circadian studies and response to ACTH

Chergui¹,

Mormède²,

Foury³

et al. 2017

Animal

View full text Add to dashboard Cite

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“…According to Sharma et al [28], thermal stress redistributes the body's nutrients including protein and energy at the expense of growth, reproduction, production and health of the animal. This enhances the occurrence of lipid peroxidation and induces changes in the fragility and antigenicity of the erythrocyte membrane [29].…”

Section: Discussionmentioning

confidence: 99%

Study of Incubation Conditions for Erythrocytes Osmotic Fragility Testing in Dromedary Camel (Camelus dromedarius)

Islah¹,

Bargaa²,

Youssef³

et al. 2016

International Journal of Research in Environmental Science

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“…As seasons change, animals undergo a highly integrated physiological adjustment aimed at maintaining homeostasis (Sharma et al 2013). In seasons with low AT, the physiological responses are aimed at reducing heat loss and increasing heat production, while in seasons with high AT, the responses aim to decrease heat production and increase heat loss.…”

Section: Thyroid Hormonesmentioning

confidence: 99%

Influence of seasonal changes on physiological variables, haematology and serum thyroid hormones profile in male Red Sokoto and Sahel goats

Habibu

Kawu

Aluwong

et al. 2016

Journal of Applied Animal Research

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The aim of this study was to evaluate the physiological responses of adult male Red Sokoto goats (n = 10; indigenous to the Guinea Savannah climate) and Sahel goats (n = 10; indigenous to the Sahel climate) at the peak of the cold-dry (CDS), hot-dry (HDS) and rainy seasons prevailing in the Guinea Savannah zone of Nigeria. Results revealed that Red Sokoto goats had significantly higher rectal temperature (RT), PCV, red blood cell (RBC), Hb, thyroxin (T 4 ), but lower respiratory rate (RR) and total leucocyte count (TLC) than Sahel goats during the CDS. Comparison within breeds for the three seasons showed that both breeds exhibited the highest (P < .05) PR, RT, neutrophil-lymphocyte ratio (N:L), but lower mean corpuscular volume and triiodothyronine (T 3 ) during the HDS. In addition, Red Sokoto goats showed higher (P < .05) RR and T 4 , but lower RBC, Hb, lymphocyte counts and T 3 :T 4 . However, Sahel goats exhibited higher (P < .05) PCV, RBC, erythrocyte osmotic fragility, but lower circulating T 4 . It was concluded that the cold and hot seasons exerted different physiological effects on the two breeds of goats with marked variation in RT, composition of blood cellular components, thyroid physiology and erythrocyte membrane integrity. ARTICLE HISTORY

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Effect of melatonin administration on thyroid hormones, cortisol and expression profile of heat shock proteins in goats (Capra hircus) exposed to heat stress

Cited by 80 publications

References 49 publications

Seasonal effects on plasma cortisol concentrations in the Bedouin buck: circadian studies and response to ACTH

Seasonal effects on plasma cortisol concentrations in the Bedouin buck: circadian studies and response to ACTH

Study of Incubation Conditions for Erythrocytes Osmotic Fragility Testing in Dromedary Camel (Camelus dromedarius)

Influence of seasonal changes on physiological variables, haematology and serum thyroid hormones profile in male Red Sokoto and Sahel goats

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