Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials

Gholami, Fatemeh; Moradi, Sajjad; Rasaei, Niloufar; Soveid, Neda; Setayesh, Leila; Mirzaei, Khadijeh

doi:10.1007/s00415-020-10381-w

Cited by 104 publications

(78 citation statements)

References 59 publications

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“…Genome-wide analyses demonstrated NKAIN2 gene in association with sleep quality and insomnia [42,43]. Since darkness is the most important regulator of melatonin secretion and light drastically reduced melatonin across the day, melatonin also reciprocally affected sleep quality and insomnia in large-scale meta-analysis [44]. From our study, it is highly likely that genetic variation of NKAIN2 affects sleep via affecting melatonin secretion.…”

Section: Discussionmentioning

confidence: 54%

A Genome-Wide Association Study for Melatonin Secretion

Liu

Chuang

Hsiung

et al. 2021

Preprint

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SummaryPurpose: Melatonin exerts a wide range of effects among various tissues and organs. However, there is currently no study to investigate the genetic determinants of melatonin secretion. Here, we conducted a genome-wide association study (GWAS) for melatonin secretion using morning urine 6-hydroxymelatonin sulfate-to-creatinine ratio (UMCR). Methods: We initially enrolled 5,000 participants from Taiwan Biobank in this study. After excluding individuals that did not have their urine collected in the morning and those who failed to pass quality control, association of single nucleotide polymorphisms with log-transformed UMCR adjusted for age, sex and principal components of ancestry were analyzed. A second model additionally adjusted for estimated glomerular filtration rate (eGFR). Results: A total of 2,504 participants underwent the genome-wide analysis. Six candidate loci associated with log UMCR (P value ranging from 7.54 x 10-7 to 4.65 x 10-6) encompassing GALNT15, ZFHX3, NKAIN2, MME and NBPF22P were identified. Similar results were yielded with further adjustment for eGFR. Interestingly, the identified genes are associated with central nervous system function and clinical condition such as Alzheimer's disease or sleep disorders.Conclusions: We conducted the first GWAS for melatonin secretion and identified six candidate genetic loci associated with melatonin level. Replication and functional studies are needed in the future.

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Section: Discussionmentioning

confidence: 54%

A Genome-Wide Association Study for Melatonin Secretion

Liu

Chuang

Hsiung

et al. 2021

Preprint

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“…22 Second, studies have shown that melatonin can improve sleep. 23 The biosynthesis of melatonin has a circadian rhythm, which is 5–10 times more at night than during the day, and normally reaches a peak at 2–3 a.m. The light on the screen of electronics will affect the melatonin secretion.…”

Section: Discussionmentioning

confidence: 99%

Relationships Between Internet Use and Sleep Duration in Chinese Adults: A Cross-Sectional Study

Fan

Yin

Tang

et al. 2021

IJGM

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Purpose Most studies that examined the relationship between internet use and sleep were conducted mainly in children and adolescents, and we know little about the use of internet among adults. The purpose of this study is to understand the internet use patterns of Chinese adults and to measure their associations with sleep duration from variety, frequency and type. Methods A total of 19,730 samples were selected from 2018 data of the China Health and Retirement Longitudinal study. Internet usage was obtained by specific questions, and the range of sleep period was grouped according to recommendations from the National Sleep Foundation. Kruskal–Wallis H -test and the chi-squared test were used for basic descriptive analysis, and multinomial logistic regression was used to analyze the relationships between internet use and sleep duration. Stata version 15.0 was used for data cleaning, and SPSS version 20.0 was used for statistics analysis. Results After screening, a total of 6346 persons were included in the analysis, of which 3148 (49.61%) were males and 3198 (50.39%) were females. Age ranged from 21 to 95 years, most persons were over 45 years old, with the median age of 56 years. Only 1180 (18.59%) participants used the internet, and almost all of them used mobile phones (1137, 96.36%), the other three types were desktop computer (232, 19.66%), laptop computer (69, 5.85%) and tablet (73, 6.19%). There were 912 (77.28%) and 268 (22.71%) participants who used only one and two or more types, respectively. In the unadjusted model, both short sleep and long sleep were associated with internet use compared with normal sleep duration (0.806 [0.708–0.918] p = 0.001; 0.345 [0.251–0.475] p < 0.000). After adjusting for all covariates, the association between long sleep and internet use still persisted (0.612 [0.433–0.865] p = 0.005), but no significant difference was found in short sleep (0.929 [0.803–1.075] p = 0.325). Conclusion Internet use was found to be closely associated with sleep and the duration of sleep negatively affected, which may provide new ideas for sleep hygiene recommendations and healthy media use. This conclusion needs more evidence to support.

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“…Melatonin is essentially secreted at night by the pineal gland and controls the sleep–wake rhythm [ 69 ]. Several systematic reviews pointed to a positive effect of exogenous melatonin on sleep disturbances [ 70 , 71 , 72 ], although administration to healthy volunteers late in the evening when natural melatonin secretion was at its maximum had no impact, in contrast to administration early in the evening [ 73 ]. Additional attributed effects include immunoregulation [ 74 , 75 ] and analgesia [ 76 ].…”

Section: Tryptophan Metabolites: the Good The Bad And The Ambivalentmentioning

confidence: 99%

What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis

Vanholder

Nigám

Burtey

et al. 2022

Toxins

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The topic of uremic toxicity has received broad attention from the nephrological community over the past few decades. An aspect that is much less often considered is the possibility that the metabolic pathways that generate uremic toxins also may produce molecules that benefit body functions. Here, we discuss this dualism based on the example of tryptophan-derived metabolites, which comprise elements that are mainly toxic, such as indoxyl sulfate, kynurenine and kynurenic acid, but also beneficial compounds, such as indole, melatonin and indole-3-propionic acid, and ambivalent (beneficial for some aspects and harmful for others) compounds such as serotonin. This dualism can also be perceived at the level of the main receptor of the tryptophan-derived metabolites, the aryl hydrocarbon receptor (AHR), which has also been linked to both harm and benefit. We hypothesize that these beneficial effects are the reason why uremic toxin generation remained preserved throughout evolution. This duality is also not unique for the tryptophan-derived metabolites, and in this broader context we discuss the remote sensing and signaling theory (RSST). The RSST proposes that transporters (e.g., organic anion transporter 1—OAT1; ATP-binding cassette transporter G—ABCG2) and drug metabolizing enzymes form a large network of proteins interacting to promote small molecule remote communication at the inter-organ (e.g., gut–liver–heart–brain–kidney) and inter-organismal (e.g., gut microbe–host) levels. These small molecules include gut microbe-derived uremic toxins as well as beneficial molecules such as those discussed here. We emphasize that this positive side of uremic metabolite production needs more attention, and that this dualism especially needs to be considered when assessing and conceiving of therapeutic interventions. These homeostatic considerations are central to the RSST and suggest that interventions be aimed at preserving or restoring the balance between positive and negative components rather than eliminating them all without distinction.

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Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials

Cited by 104 publications

References 59 publications

A Genome-Wide Association Study for Melatonin Secretion

A Genome-Wide Association Study for Melatonin Secretion

Relationships Between Internet Use and Sleep Duration in Chinese Adults: A Cross-Sectional Study

What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis

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