Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats

Rateb, Enas Ezzat; Amin, Shaimaa Nasr; Eltablawy, Nashwa; Rashed, Laila Ahmed; Elattar, Samah

doi:10.17179/excli2016-763

Cited by 12 publications

(11 citation statements)

References 44 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thence, finding a long-lasting and convenient way to improve stem cells combined with Mel to promote nerve axonal regeneration is essential. In addition to this, several studies confirmed that only the use of Mel has a beneficial effect on the regeneration of myelin sheaths in PNI [ 60 , 61 ]. Therefore, we use ADSCs combined with Mel to inject the lesion to treat the peripheral nerve injury.…”

Section: Discussionmentioning

confidence: 72%

ADSCs Combined with Melatonin Promote Peripheral Nerve Regeneration through Autophagy

Zhang

et al. 2022

International Journal of Endocrinology

View full text Add to dashboard Cite

Background. In the early stage of nerve injury, damaged tissue is cleared by autophagy. ADSCs can promote nerve axon regeneration. However, the microenvironment of the injury was changed, and ADSCs are easily apoptotic after transplantation. Mel plays a role in the apoptosis, proliferation, and differentiation of ADSCs. Therefore, we investigated whether Mel combined with ADSCs promoted peripheral nerve regeneration by enhancing early autophagy of injured nerves. Materials and Methods. SD rats were randomly split into the control group, model group, Mel group, ADSCs group, ADSCs + Mel group, and 3-MA group. On day 7, autophagy was observed and gait was detected on days 7, 14, 21, and 28. On the 28th day, the sciatic nerve of rats’ renewal was detected. Results. After 1 w, compare with the model group, the number of autophagosomes and lysosomes and the expressions of protein of LC3-II/LC3-I and Beclin-1 in the ADSCs + Mel group were prominently increased, while the 3-MA group was significantly decreased. After 4 w, the function of the sciatic nerve in ADSCs + Mel was similar to that in the control group. Compared with the model group, the ADSCs + Mel group significantly increased myelin regeneration and the number of motor neurons and reduced gastrocnemius atrophy. Conclusions. It was confirmed that ADSCs combined with Mel could promote sciatic nerve regeneration in rats by changing the early autophagy activity of the injured sciatic nerve.

show abstract

Section: Discussionmentioning

confidence: 72%

ADSCs Combined with Melatonin Promote Peripheral Nerve Regeneration through Autophagy

Zhang

et al. 2022

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Duan et al 2018 obtain that melatonin administration was efficacious in preventing an increase in NGF in the asthma in rats model (Duan et al 2018 ). Conversely, Rateb et al 2017 , in their study on rats with a sciatic nerve lesion, conclude that treatment with melatonin increases NGF activity, reinforcing neural recovery and favoring a better nerve regeneration (Rateb et al 2017 ). It has also been verified that melatonin can trigger the expression of the glial cell line-derived neurotrophic factor (GDNF), in neural stem cells, which could encourage the survival of dopaminergic neurons (Niles et al 2004 ).…”

Section: Multiple Sclerosis Melatonin and Neurotrophic Factors Neurog...mentioning

confidence: 99%

Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action

et al. 2022

View full text Add to dashboard Cite

Background Melatonin is an indole hormone secreted primarily by the pineal gland that showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important role in the pathophysiological mechanisms of various diseases. In this regard, different studies have shown that there is a relationship between Melatonin and Multiple Sclerosis (MS). MS is a chronic immune-mediated disease of the Central Nervous System. Aim The objective of this review was to evaluate the mechanisms of action of melatonin on oxidative stress, inflammation and intestinal dysbiosis caused by MS, as well as its interaction with different hormones and factors that can influence the pathophysiology of the disease. Results Melatonin causes a significant increase in the levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione and can counteract and inhibit the effects of the NLRP3 inflammasome, which would also be beneficial during SARS-CoV-2 infection. In addition, melatonin increases antimicrobial peptides, especially Reg3β, which could be useful in controlling the microbiota. Conclusion Melatonin could exert a beneficial effect in people suffering from MS, running as a promising candidate for the treatment of this disease. However, more research in human is needed to help understand the possible interaction between melatonin and certain sex hormones, such as estrogens, to know the potential therapeutic efficacy in both men and women.

show abstract

“…Thirteen articles addressed the role of melatonin after PNI [ 7 , 61 - 72 ], all of which were conducted in a rat model except for two mouse studies [ 61 , 62 ]. Melatonin improved structural preservation of the myelin sheaths [ 61 ], neural regeneration [ 72 ], functional outcomes [ 7 , 65 , 67 ], nerve conduction velocity [ 65 ], Schwann cell proliferation [ 64 ], axonal regeneration [ 66 ], increased malondialdehyde [ 62 ], decreased nerve peroxidation [ 63 ], and reduced oxidative stress [ 68 , 71 ].…”

Section: Reviewmentioning

confidence: 99%

The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature

Abushukur¹,

Knackstedt²

2022

Cureus

View full text Add to dashboard Cite

Peripheral nerve injury (PNI) can result from trauma, surgical resection, iatrogenic injury, and/or local anesthetic toxicity. Damage to peripheral nerves may result in debilitating weakness, numbness, paresthesia, pain, and/or autonomic instability. As PNI is associated with inflammation and nerve degeneration, means to mitigate this response could result in improved outcomes. Numerous nutrients have been investigated to prevent the negative sequelae of PNI. Alpha-lipoic acid, cytidine diphosphate-choline (CDP Choline), curcumin, melatonin, vitamin B12, and vitamin E have demonstrated notable success in improving recovery following PNI within animal models. While animal studies show ample evidence that various supplements may improve recovery after PNI, similar evidence in human patients is limited. The goal of this review is to analyze supplements that have been used successfully in animal models of PNI to serve as a reference for future studies on human patients. By analyzing supplements that have shown efficacy in animal studies, healthcare providers will have a resource from which to guide decision-making regarding future human studies investigating the role that supplements could play in PNI recovery. Ultimately, establishing a comprehensive understanding of these supplements in human patients following PNI may significantly improve post-surgical outcomes, quality of life, and peripheral nerve regeneration.

show abstract

Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats

Cited by 12 publications

References 44 publications

ADSCs Combined with Melatonin Promote Peripheral Nerve Regeneration through Autophagy

ADSCs Combined with Melatonin Promote Peripheral Nerve Regeneration through Autophagy

Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action

The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature

Contact Info

Product

Resources

About