Effect of melt extrudability and melt binding efficiency of polyvinyl caprolactam polyvinyl acetate polyethylene glycol graft copolymer (Soluplus®) on release pattern of hydrophilic and high dose drugs

Ayyub, K. Tousif; Moravkar, Kailas K.; Maniruzzaman, Mohammed; Amin, Purnima D.

doi:10.1016/j.msec.2019.01.126

Cited by 14 publications

(7 citation statements)

References 40 publications

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“…About 90% of the drug had been released from polymeric solutions, whereas the bulk FLU solution showed about 100% release in 2 h. The slight delay in the release of the drug from the polymeric solution could be attributed to the chemistry of amphiphilic polymer, Soluplus ® . It has been reported that Soluplus ® tends to retard the release of the sparingly water-soluble drug upon swelling in the dissolution media [19]. Comparing the dissolution profiles of the 13 mm and the 10 mm tablets coated by solution C showed that these dissolution profiles were different ( f 2 value of 43; f 2 value (similarity test); less than 50 indicates that they are different).…”

Section: Resultsmentioning

confidence: 99%

Drop-On-Powder 3D Printing of Tablets with an Anti-Cancer Drug, 5-Fluorouracil

et al. 2019

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This study reports the first case of an innovative drop-on-powder (DoP) three-dimensional (3D) printing technology to produce oral tablets (diameters of 10 mm and 13 mm) loaded with an anticancer model drug, 5-fluorouracil (FLU). For this study, a composition of the powder carrier containing CaSO4 hydrates, vinyl polymer, and carbohydrate was used as the matrix former, whereas 2-pyrrolidone with a viscosity like water was used as a binding liquid or inkjet ink. All tablets were printed using a commercial ZCorp 3D printer with modification. The resultant tablets were subject to coating with various polymeric solutions containing the drug. The composition of the polymeric solutions was adjusted at drug: polymer(s) 1:1 (w/w) ratio. Either Soluplus® (SOL) alone or in combination with polyethylene glycol (PEG) was used to develop the coating solution of 2.5% (w/v) concentration. The particle size analysis, flow test, and particle morphology studies revealed mono-modal narrow size distribution, good flow properties, and porous loosely bound texture (of the tablets), respectively. Moreover, the advanced application of the fluorescence microscopy showed a homogenous distribution of the drug throughout the surface of the 3D printed tablets. The in vitro dissolution studies showed that the tablet compositions, dimensions, and the coating solution compositions influenced the release of the drug from the tablets. It can be concluded that our innovative DoP 3D printing technology can be used to fabricate personalized dosage forms containing optimized drug content with high accuracy and shape fidelity. This is particularly suitable for those drugs that are highly unstable in thermal processing and cannot withstand the heat treatment, such as in fused deposition modeling (FDM) 3D printing.

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Section: Resultsmentioning

confidence: 99%

Drop-On-Powder 3D Printing of Tablets with an Anti-Cancer Drug, 5-Fluorouracil

et al. 2019

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“…It is also proposed to increase the solubility and bioavailability of poorly soluble molecules through the formed micelles. Moreover, as a polymer, it has a tendency not to absorb moisture from the air [ 116 , 117 ].…”

Section: Excipients Used In Ocular Formulations For Modified Drug Deliverymentioning

confidence: 99%

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

et al. 2021

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In ocular drug delivery, maintaining an efficient concentration of the drug in the target area for a sufficient period of time is a challenging task. There is a pressing need for the development of effective strategies for drug delivery to the eye using recent advances in material sciences and novel approaches to drug delivery. This review summarizes the important aspects of ocular drug delivery and the factors affecting drug absorption in the eye including encapsulating excipients (chitosan, hyaluronic acid, poloxamer, PLGA, PVCL-PVA-PEG, cetalkonium chloride, and gelatin) for modified drug delivery.

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“…Generally, the screw rotational speed is associated with the shear stress applied and the residence time of composite melt during compounding in an extruder. An increase in screw speed up will cause one of two distinct occurrences: (1) it will produce higher shear stress on the melt and thus promotes better distribution of the filler within the polymer matrix, which results in improved mechanical properties, or (2) it will reduce the residence time of melt in the extruder, which causes an incomplete melt compounding process (Ayyub et al 2019). As for the effect of the screw speed on the tensile strength of PLA/BP composites, with varying screw speeds, no major difference was observed between the tensile strength values.…”

Section: Tensile Strengthmentioning

confidence: 99%

Parameter optimization via the Taguchi method to improve the mechanical properties of bamboo particle reinforced polylactic acid composites

Fazita

Johary

Khalil

et al. 2021

BioRes

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Reinforcement with natural fibres is a common method to improve impact properties of poly(lactic acid) (PLA). In this study, composites made from PLA and bamboo particles were melt-compounded in a twin-screw extruder and formed by compression moulding. Tensile, flexural, and impact tests were conducted. Particle size (A), particle loading (B), screw speed (C), and die temperature (D) were varied at three levels. Tensile strength and modulus, flexural strength and modulus, and impact strength were the response variables. The experiment design was based on Taguchi’s (L9) orthogonal array. Through variance analysis, the particle loading was found to be the dominant factor influencing the mechanical properties, followed by die temperature. The optimum parameters were validated with a confirmation test. The results showed a noticeable improvement of impact properties compared to neat PLA by 55%, without compromising tensile and flexural properties. Flexural strength, flexural modulus, and tensile modulus of the composites were greater than that of pure PLA. However, only tensile strength was reduced by about 28% compared to pure PLA. Importantly, the DOE method with maximizing the desirability properties was found to be an effective systematic approach to identify an optimal parameter setting of the extrusion moulding process.

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Effect of melt extrudability and melt binding efficiency of polyvinyl caprolactam polyvinyl acetate polyethylene glycol graft copolymer (Soluplus®) on release pattern of hydrophilic and high dose drugs

Cited by 14 publications

References 40 publications

Drop-On-Powder 3D Printing of Tablets with an Anti-Cancer Drug, 5-Fluorouracil

Drop-On-Powder 3D Printing of Tablets with an Anti-Cancer Drug, 5-Fluorouracil

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

Parameter optimization via the Taguchi method to improve the mechanical properties of bamboo particle reinforced polylactic acid composites

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