Effect of menstrual cycle and female hormones on TRP and TREK channels in modifying thermosensitivity and physiological functions in women

Uchida, Yuzo; Izumizaki, Masahiko

doi:10.1016/j.jtherbio.2021.103029

Cited by 5 publications

(2 citation statements)

References 97 publications

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“…TRP channels are transmembrane protein complexes, and steroids, including estrogen, progesterone and androgens, have been found to affect the physiology of the cells and regulate where TRP channels are expressed [24]. Regarding the roles of TRP channels in in ammatory pain, evidence suggests that in ammatory mediators can sensitize or alter the threshold of TRP channels, leading to pain behaviors [25].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of TRPM3 by primidone provides a potential therapeutic method for adenomyosis management

Jin

Peng

et al. 2023

Preprint

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Purpose To test the expression profile of transient receptor potential channels (TRPs) in adenomyosis patients and evaluate the effects of primidone on tamoxifen-induced adenomyosis mice. Methods Eutopic endometrium from adenomyosis patients (n = 20) was collected and subjected to mRNA analysis of TRP channels. TRPA1, TRPV1 and TRPM3 in adenomyosis patients (n = 50) and tamoxifen-induced adenomyosis mice (n = 6) were examined by immunohistochemistry. From 10 weeks after birth, primidone (2 mg/kg/d) and atosiban (1 mg/kg/d) were given separately to adenomyotic mice by intraperitoneal injection for 3 weeks. The hotplate test was conducted once a week beginning at 10 weeks, and then uterine samples were harvested for HE staining and RNA-seq at 13 weeks. Results The mRNA expression of 15 TRPs was significantly increased in the proliferative phase of the adenomyotic endometrium. TRPV1, TRPM3 or TRPA1 staining levels were positively correlated with dysmenorrhea severity, menses amount and uterine size. In tamoxifen-induced adenomyosis mice, primidone had a significant effect on both the depth of myometrial infiltration and analgesia. Forty-seven DEGs were identified after primidone treatment, and bioinformatics analysis predicted that they were enriched in the cell cycle and cell division. Conclusion The expression profile of TRP channels varies significantly in adenomyosis patients, and primidone may provide a potential therapeutic method for adenomyosis management.

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Section: Discussionmentioning

confidence: 99%

Inhibition of TRPM3 by primidone provides a potential therapeutic method for adenomyosis management

Jin

Peng

et al. 2023

Preprint

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“…Recently, the STIM1-Orai1 complex was found to interact with TRPC channels required for their activation [42,43]. Other members of the TRP channel family are vanilloid (TRPV) receptors, ankyrin (TRPA) and melastatin (TRPM), of which TRPV1 and TRPV4 have been identified in ASM cells (Figure 3) [24,[44][45][46][47].…”

Section: Store-operated Calcium Channelsmentioning

confidence: 99%

Estrogenic Modulation of Ionic Channels, Pumps and Exchangers in Airway Smooth Muscle

Romero‐Martínez

Sommer

Solís‐Chagoyán

et al. 2023

IJMS

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To preserve ionic homeostasis (primarily Ca2+, K+, Na+, and Cl−), in the airway smooth muscle (ASM) numerous transporters (channels, exchangers, and pumps) regulate the influx and efflux of these ions. Many of intracellular processes depend on continuous ionic permeation, including exocytosis, contraction, metabolism, transcription, fecundation, proliferation, and apoptosis. These mechanisms are precisely regulated, for instance, through hormonal activity. The lipophilic nature of steroidal hormones allows their free transit into the cell where, in most cases, they occupy their cognate receptor to generate genomic actions. In the sense, estrogens can stimulate development, proliferation, migration, and survival of target cells, including in lung physiology. Non-genomic actions on the other hand do not imply estrogen’s intracellular receptor occupation, nor do they initiate transcription and are mostly immediate to the stimulus. Among estrogen’s non genomic responses regulation of calcium homeostasis and contraction and relaxation processes play paramount roles in ASM. On the other hand, disruption of calcium homeostasis has been closely associated with some ASM pathological mechanism. Thus, this paper intends to summarize the effects of estrogen on ionic handling proteins in ASM. The considerable diversity, range and power of estrogens regulates ionic homeostasis through genomic and non-genomic mechanisms.

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Pharmacological effects of cannabidiol by transient receptor potential channels

et al. 2022

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Effect of menstrual cycle and female hormones on TRP and TREK channels in modifying thermosensitivity and physiological functions in women

Cited by 5 publications

References 97 publications

Inhibition of TRPM3 by primidone provides a potential therapeutic method for adenomyosis management

Inhibition of TRPM3 by primidone provides a potential therapeutic method for adenomyosis management

Estrogenic Modulation of Ionic Channels, Pumps and Exchangers in Airway Smooth Muscle

Pharmacological effects of cannabidiol by transient receptor potential channels

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