Effect of menthol/mint-flavored pods on young JUUL E-cigarette users’ subjective experience, puffing behavior, and nicotine exposure: A pilot study

Li, Wei; Vargas-Rivera, Mayra; Eissenberg, Thomas; Shihadeh, Alan; Talih, Soha; Maziak, Wasim

doi:10.1016/j.drugalcdep.2022.109516

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…In a survey, participants using JUUL ECs for the first time experienced burning in the throat, coughing, wheezing, and headache . Immediately after vaping JUUL “Menthol”/“Mint” or “Classic Tobacco”, participants reported nausea and dizziness . Additionally, 40.1% of JUUL adolescent users who vaped in the past 30 days were likely to have nicotine dependence symptoms (e.g., cravings) .…”

Section: Introductionmentioning

confidence: 99%

“…30 Immediately after vaping JUUL "Menthol"/"Mint" or "Classic Tobacco", participants reported nausea and dizziness. 31 Additionally, 40.1% of JUUL adolescent users who vaped in the past 30 days were likely to have nicotine dependence symptoms (e.g., cravings). 32 JUUL vaping also increased blood pressure and mean arterial pressure in human users.…”

Section: ■ Introductionmentioning

confidence: 99%

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Exposure, Retention, Exhalation, Symptoms, and Environmental Accumulation of Chemicals During JUUL Vaping

Hua

Luo

Khachatoorian

et al. 2023

Chem. Res. Toxicol.

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Little is known about the chemical exposures that electronic cigarette (EC) users receive and emit during JUUL vaping and if exposures produce symptoms dose dependently. This study examined chemical exposure (dose), retention, symptoms during vaping, and the environmental accumulation of exhaled propylene glycol (PG), glycerol (G), nicotine, and menthol in a cohort of human participants who vaped JUUL "Menthol" ECs. We refer to this environmental accumulation as "EC exhaled aerosol residue" (ECEAR). Chemicals were quantified using gas chromatography/mass spectrometry in JUUL pods before and after use, lab-generated aerosols, human exhaled aerosols, and in ECEAR. Unvaped JUUL "Menthol" pods contained ∼621.3 mg/mL of G, ∼264.9 mg/mL of PG, ∼59.3 mg/mL of nicotine, ∼13.3 mg/mL of menthol, and ∼0.1 mg/mL of the coolant WS-23. Eleven experienced male EC users (aged 21−26) provided exhaled aerosol and residue samples before and after vaping JUUL pods. Participants vaped ad libitum for 20 min, while their average puff count (22 ± 6.4) and puff duration (4.4 ± 2.0) were recorded. The transfer efficiency of nicotine, menthol, and WS-23 from the pod fluid into the aerosol varied with each chemical and was generally similar across flow rates (9−47 mL/s). At 21 mL/s, the average mass of each chemical retained by the participants who vaped 20 min was 53.2 ± 40.3 mg for G, 18.9 ± 14.3 mg for PG, 3.3 ± 2.7 mg for nicotine, and 0.5 ± 0.4 mg for menthol, with retention deduced to be ∼90−100% for each chemical. There was a significant positive relationship between the number of symptoms during vaping and total chemical mass retained. ECEAR accumulated on enclosed surfaces where it could contribute to passive exposure. These data will be valuable to researchers studying human exposure to EC aerosols and agencies that regulate EC products.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Exposure, Retention, Exhalation, Symptoms, and Environmental Accumulation of Chemicals During JUUL Vaping

Hua

Luo

Khachatoorian

et al. 2023

Chem. Res. Toxicol.

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“…In a recent study, Li, et al 27 confirmed that menthol/mint flavour may encourage the vape appealing by young users for e‐cigarette. Thus, the control of menthol/mint flavour administration is potentially a promising way to decrease e‐cigarette dependency among young people.…”

Section: Resultsmentioning

confidence: 94%

“…In a recent study, Li, et al 27 confirmed that menthol/mint flavour may encourage the vape appealing by young users for e-cigarette.…”

Section: Menthol Perceptionmentioning

confidence: 94%

Application of therate‐all‐that‐applymethod to explore the perception of flavours provided by e‐cigarettes: Importance of 1.3‐propanediol

Nhouchi¹,

Belay²,

Hanaei³

et al. 2023

Flavour & Fragrance J

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The self‐administration of nicotine using e‐cigarettes involves the use of liquids containing both solvent and aroma. The vaping appeal is enhanced by the sensory perception of flavours. Thus, an important attention may be paid to the choice of the refill liquid. For this purpose, this study aimed to evaluate the potential of 1,3‐propanediol (PDO, vegetal solvent) and 1,3‐butanediol (BDO, vegetal solvent), in replacing the chemical one such 1,2‐propanediol (PG) while maintaining sensory pleasure and ensuring the wellbeing. The work was conducted with 30 participants accustomed to vaping. Three flavours have been selected, menthol, vanillin and pyrazine, respectively, to provide the most preferred perceptions which are respectively mint, sweet and tobacco. The Rate‐All‐That‐Apply (RATA) method was chosen since it is rapid and robust. Menthol/PDO and menthol/PG exhibited a close olfactive profile, described as minty, cold and sweet. A similar finding has been observed for vanillin/PDO and vanillin/PG. The use of BDO provided different perceptions in comparison with PDO and PG regardless of the type of flavour. It was found to be the most suitable for pyrazine perception. These results were enhanced by the application of the agglomerative hierarchical clustering (AHC). The obtained dendrogram was composed of three groups according to their similarities, where e‐liquids containing PDO, and PG belongs to the same groups for both menthol and vanillin.

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“…One of the most consistent findings for the impact of flavorants on nicotine product use is the effect of menthol. More positive attitudes have been reported toward mint/menthol flavored electronic cigarettes compared to tobacco flavored electronic cigarettes, which was evidenced by an increased reported satisfaction and increased likelihood to repeat use ( 145 ). In those who smoke mentholated tobacco cigarettes, decreased smoking cessation rates are found ( 146 ), indicating that mentholated products have increased addiction liability.…”

Section: Health Consequences and Neurobiological Effects Of Electroni...mentioning

confidence: 99%

Beyond the label: current evidence and future directions for the interrelationship between electronic cigarettes and mental health

2023

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Electronic cigarette use has dramatically increased over the last decade. With this recent technological development and wide range of constituents in various products, putative adverse effects on the brain and body have been largely unexplored. Here, we review current evidence linking electronic nicotine cigarette use with potential health consequences and provide evidence supporting an association between drug use and depression in humans. We also examine the biological effects of individual constituents in electronic cigarette aerosols, which include labeled ingredients, such as propylene glycol, vegetable glycerin, nicotine, and flavorants, as well as unlabeled ingredients found in the aerosols, such as carbonyls and heavy metals. Lastly, we examine the effects of electronic cigarette use on endogenous metabolism via changes in cytochrome P450 enzymes, which can thereby impact therapeutic outcomes. While the current evidence offers insight into the potential effects of electronic cigarette use on biological processes, further studies are necessary to determine the long-term clinical relevance of aerosol inhalation.

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Effect of menthol/mint-flavored pods on young JUUL E-cigarette users’ subjective experience, puffing behavior, and nicotine exposure: A pilot study

Cited by 7 publications

References 22 publications

Exposure, Retention, Exhalation, Symptoms, and Environmental Accumulation of Chemicals During JUUL Vaping

Exposure, Retention, Exhalation, Symptoms, and Environmental Accumulation of Chemicals During JUUL Vaping

Application of therate‐all‐that‐applymethod to explore the perception of flavours provided by e‐cigarettes: Importance of 1.3‐propanediol

Beyond the label: current evidence and future directions for the interrelationship between electronic cigarettes and mental health

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