Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

Tian, Lili; Peng, Chao-Chung; Shi, Ying; Guo, X Z; Zhong, Bo; Qi, Juanjuan; Wang, Guanhong; Cai, Qiang; Cui, Fuzhai

doi:10.4012/dmj.2013-215

Cited by 61 publications

(51 citation statements)

References 26 publications

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“…For the treatment of dentin hypersensitivity, several different strategy of treatment have being studied. One of these strategies is to occlude the exposed dentin surface, especially the tubule orifices, by using various agents that includes different active ingredients (Arnold et al, ; Earl et al, ; Tian et al, ). Since hydroxyapatite is one of the main components of human bones and teeth and it has good biocompatibility and bioactivity, synthetic hydroxyapatite has become one of the hot topics for biological material research over the past few decades (Cummins, ; Lee et al, ; Lin et al, ; Wang et al, ; Yu et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Some commercially available nHAp preparates are in powder form and some in paste form as dentifrices (Shetty, Kohad, & Yeltiwar, ; Tian et al, ). There are several methods to produce nHAp crystals like, hydrolyzation of calcium phosphate (Fowler, ; Monma & Kamiya, ), hydrothermal synthesis (Hattori, Iwadate, & Kato, ; Huang et al, ), spray pyrolysis (Inoue & Ono, ), freeze‐drying (Hattori, Iwadate, Inai, Sato, & Imai, ), sol‐gel technique (Masuda, Matubara, & Sakka, ), gel difusion, electrochemical deposition, and precipitation (Huang et al, ; Turkoz, Atilla, & Evis, ; Zafer, ).…”

Section: Introductionmentioning

confidence: 99%

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Dentinal tubule occluding capability of nano‐hydroxyapatite; The in‐vitro evaluation

Bağlar

Erdem

Doğan

et al. 2018

Microscopy Res & Technique

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In this in-vitro study, the effectiveness of experimental pure nano-hydroxyapatite (nHAP) and 1%, 2%, and 3% F¯ doped nano-HAp on dentine tubule occlusion was investigated. And also, the cytotoxicity of materials used in the experiment was evaluated. Nano-HAp types were synthesized by the precipitation method. Forty dentin specimens were randomly divided into five groups of; 1-no treatment (control), 2-specimens treated with 10% pure nano-HAp and 3, 4, 5 specimens treated with 1%, 2%, and 3% F doped 10% nano-HAp, respectively. To evaluate the effectiveness of the materials used; pH, FTIR, and scanning electron microscopy evaluations were performed before and after degredation in simulated body fluid. To determine cytotoxicity of the materials, MTT assay was performed. Statistical evaluations were performed with F and t tests. All of the nano-HAp materials used in this study built up an effective covering layer on the dentin surfaces even with plugs in tubules. It was found that this layer had also a resistance to degradation. None of the evaluated nano-HAp types were have toxicity. Fluoride doping showed a positive effect on physical and chemical stability until a critical value of 1% F . The all evaluated nano-HAp types may be effectively used in dentin hypersensitivity treatment. The formed nano-HAp layers were seem to resistant to hydrolic deletion. The pure and 1% F doped nano-HAp showed the highest biocompatibility thus it was assessed that pure and 1% F doped materials may be used as an active ingredient in dentin hypersensitivity agents.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dentinal tubule occluding capability of nano‐hydroxyapatite; The in‐vitro evaluation

Bağlar

Erdem

Doğan

et al. 2018

Microscopy Res & Technique

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“…[50][51][52] The idea behind this approach is that nanoparticles may easily penetrate into dentine tubules and that these nanoparticles could act as mineralising agents that block fluid movement within the dentine tubules when combined with various agents.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of various toothpastes on dentine tubule occlusion

Arnold¹,

Prange²,

Naumova³

2015

Journal of Dentistry

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“…Nano-sized materials with good scattering can enter dentinal tubules of 2-3µm diameters easily; thus, they can be ultimate choice for dentinal tubule occlusion. The greater surface energy and larger surface area fundamentally increase the solvency and reactivity of nanoparticles (5) . Nano Forsterite (Mg 2 Sio 4 ) is a phase of MgO-SiO 2 system that shows high biocompatibility and good mechanical properties (6) .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Application of Forsterite Nanoparticles in Different Protocols on Permeability of Superficial and Deep Dentin

et al. 2019

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Purpose: This study evaluated and compared the effect of application of Forsterite nanoparticles in different protocols on permeability of superficial and deep dentin at different time intervals. Materials and methods: thirty human molars were used to prepare 60 dentin discs, divided into three main groups (n=20) (P); (P1): Forsterite nanoparticles alone, (P2): Forsterite nanoparticles added to an adhesive system and (P3): Forsterite nanoparticles incorporated in Glass Ionomer. The main groups were subdivided into two subgroups (n=10) according to the dentin depth (D); (D1): superficial dentin and (D2): deep dentin. Permeability was measured at three time intervals (T); (T1) baseline, (T2) after one week and (T3) after four weeks. Three wt% of forsterite nanoparticles were added to adhesive system and Glass ionomer. Teeth were sectioned to obtain superficial and deep dentin discs of; 1 mm (± 0.1mm) thickness. Modified Pashly's split chamber was used to measure dentin permeability at baseline and after application of different protocols. Representative samples were assessed with ESEM and EDAX. Results: all protocols showed permeability reduction. (P2) showed the least permeability at T2 for superficial and deep dentin discs, (P1) showed the least permeability at T3 for both superficial and deep dentin discs and (P3) showed the least permeability reduction. Conclusion: it was concluded that Forsterite nanoparticles applied in different protocols can reduce dentin permeability in superficial and deep dentin. Superior dentin permeability reduction could be achieved after one week of using Forsterite nanoparticles added to the adhesive system and four weeks after using Forsterite nanoparticles alone.

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Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

Cited by 61 publications

References 26 publications

Dentinal tubule occluding capability of nano‐hydroxyapatite; The in‐vitro evaluation

Dentinal tubule occluding capability of nano‐hydroxyapatite; The in‐vitro evaluation

Effectiveness of various toothpastes on dentine tubule occlusion

The Effect of Application of Forsterite Nanoparticles in Different Protocols on Permeability of Superficial and Deep Dentin

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