Effect of Metabolic "Stress" on Development of Tumor Following Inoculation of Walker Carcinosarcoma Cells.

Griffiths, John; Hoppe, Everett

doi:10.3181/00379727-104-25875

Cited by 6 publications

(2 citation statements)

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“…by the time the tumor on the leg is palpable, the immunologic memory has moved centrally and very little resides in the regional nodes. In these experiments, the effect of stress on tumor "takes" reported by Griffiths and Hoppe (1960), and the effect of stress on immunologic competence reported by Wingard et al (1967), was evaluated as one of the control groups. responsiveness in the mouse.…”

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confidence: 99%

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Restoration of immunologic memory in the tumor‐bearing mouse

Humphrey

Boehm

Fetter

1974

Journal of Surgical Oncology

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Using C3H/HeHa mice and a transplanted methylcholanthrene sarcoma induced in this strain, the effect of simple and radical amputation of the tumor-bearing leg on tumor immunity was evaluated. Radical amputation of the tumor-bearing leg removed the protective effect upon subsequent tumor challenge while immunity was present in mice submitted to only simple amputation of the tumor-bearing leg. However, radical amputation of the contralateral normal leg resulted in failure to demonstrate protection to subsequent challenge. These data suggest that severe stress is the cause of lack of demonstrable immunity in these mice.tation. When injected immediately after the operative stress, no immunity to tumor was seen. On the other hand, if the vaccine was injected 12 days after operation, protection once again was demonstrated.

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confidence: 99%

“…In these experiments, the effect of stress on tumor "takes" reported by Griffiths and Hoppe (1960), and the effect of stress on immunologic competence reported by Wingard et al (1967), was evaluated as one of the control groups.…”

mentioning

confidence: 99%