Effect of Metabolic Syndrome on the Incidence of Dementia Based on National Insurance Data in Korea

Yoo, Hai-Won; Kim, Hyeongsu; Koh, Im-Seok; Lee, Kun Sei; Ok, JongSun

doi:10.1089/met.2021.0046

Cited by 1 publication

(2 citation statements)

References 22 publications

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Section: Discussionmentioning

confidence: 99%

“…Europe and Asia which found that MetS was associated with a statistically significant elevated risk of all-cause dementia, 6,9 Alzheimer's disease, 6,48 and vascular dementia. 6,13,14,48 To our knowledge, only two comparable studies found a significant positive association with incident all-cause dementia. A record linkage study in South Korea of over four million individuals aged ≥40 years reported a 12% increased risk of all-cause dementia over a mean follow-up of 4.9 years, 6 while a Taiwanese study reported that worsened MetS (ie, those who did not have MetS at the first time point, but developed it at the second time point over a 5-year period) was associated with a twofold increased risk of all-cause dementia in those aged ≥65 years over a 10year period.…”

Section: Discussionmentioning

confidence: 99%

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Association between metabolic syndrome and risk of incident dementia in UK Biobank

Qureshi,

Collister,

Allen

et al. 2023

Alzheimer's & Dementia

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INTRODUCTIONThe association between metabolic syndrome (MetS) and incident dementia remains inconclusive.METHODSIn 176,249 dementia‐free UK Biobank participants aged ≥60 years at baseline, Cox proportional‐hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high‐density lipoprotein cholesterol.RESULTSOver 15 years of follow‐up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow‐up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein‐E (APOE)‐ε4 non‐carriers.DISCUSSIONIn this large population‐based prospective cohort, MetS was associated with an increased risk of dementia.Highlights MetS was associated with a 12% increased risk of incident all‐cause dementia. Associations remained similar after restricting the analysis to those with longer follow‐up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.

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