Effect of metastasectomy on survival in patients with metastatic Renal Cell Cancer: 10 years experience in 240 patients

Staehler, Michael; Kruse, Jessica; Haseke, Nicolas; Städler, Thomas; Karl, Alexander; Bruns, C; Graeb, Christian; Jauch, Karl Walter; Stief, Christian G.

doi:10.1200/jco.2008.26.15_suppl.5107

Cited by 3 publications

(1 citation statement)

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“…In these cases, complete tumour resection comprising nephrectomy and resection of tumour-infiltrated parts or segments of the IVC or IVC-associated tumour thrombus has to be the basic aim of surgical treatment if there are no distant metastases. Since there are surgical options to achieve R0 resection status in case of an IVC tumour thrombus but no distant metastases, this seems to be of no significant disadvantage for patient’s prognosis,18 – 20 although there is no extensive experience on this subject. Again, the aim is, despite primarily advanced tumour growth, to achieve macro- and microscopically complete resection to provide the patient’s best outcome.…”

Section: Discussionmentioning

confidence: 99%

Successful interdisciplinary treatment of renal cell carcinoma with tumour thrombus into inferior vena cava using multimodal protocol and organ-extending R0 resection in rare horseshoe kidney and doubled right organ

Janitzky

Meyer²,

Halloul³

et al. 2010

Case Reports

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This is the first case ever reported showing a combination of renal cell carcinoma (RCC) with tumour thrombus into inferior vena cava (IVC), horseshoe kidney and doubled right kidney that was successfully treated. Even in advanced tumour lesions of the kidney, curative treatment is a feasible and safe option by using interdisciplinary cooperation and expertise. However, this requires an adequate diagnostic work-up to clarify resectability and optimal perioperative and postoperative care, and also advanced surgical skills exhausting all potential options for complete tumour resection in a centre of excellence. Achieving R0 resection with a reasonable risk-benefit ratio for the patient, which should be the primary aim, can distinctly improve survival chances as published cases in literature have indicated. RCC-derived IVC tumour thrombus as an extra-renal tumour manifestation by continuous intravascular tumour growth (also classified as secondary IVC tumour lesion) can be considered no serious contraindication to aim for curative surgery.

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Section: Discussionmentioning

confidence: 99%

Successful interdisciplinary treatment of renal cell carcinoma with tumour thrombus into inferior vena cava using multimodal protocol and organ-extending R0 resection in rare horseshoe kidney and doubled right organ

Janitzky

Meyer²,

Halloul³

et al. 2010

Case Reports

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Aggressive Fibromatose (Desmoidfibromatose)

Janitzky

Porsch

Küster

et al. 2009

Urologe

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We report the case of a 65-year-old woman with an aggressive fibromatosis of the rectus abdominis muscle suspicious for a metastasis of renal cell carcinoma after tumor nephrectomy 3 years previously. Aggressive fibromatoses (desmoid tumors) are rare semimalignant tumors of the connective tissue with local infiltration and destruction of tissue. Complete resection is essential to avoid tumor relapse. Aggressive fibromatosis must be considered in the differential diagnosis of renal cell carcinoma metastasis. Complete resection and subsequent radiotherapy seem to be the therapy of choice.

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