Effect of Metformin on inflammatory markers involved in Cardiotoxicity induced by Doxorubicin

Shaty, Mohammed Hussein; Al-Ezzi, Muthanna I.; Arif, Inam Sameh; Hanna, Dalya Basil

doi:10.5958/0974-360x.2019.01007.2

Cited by 11 publications

(1 citation statement)

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“…Consistently, adiponectin suppresses neutrophil membrane ceramide accumulation and inhibits neutrophil apoptosis via AMPK [ 77 ]. In monocytes/macrophages, adiponectin suppresses the production of TNF-α and IL-6 and induces the production of IL-10 and IL-1 receptor antagonist anti-inflammatory mediators [ 78 , 79 ]. Cancer-induced chronic inflammation has emerged as a key driver of CC, due to the multiorgan pathology and associated wide range of metabolic and endocrine disorders that lead to tissue dysfunction [ 65 ].…”

Section: Highlighting Exerkines In Cancer Cachexiamentioning

confidence: 99%

Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review

Ahmadi Hekmatikar,

Nelson,

Petersen

2023

BMC Cancer

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Background Exerkines are all peptides, metabolites, and nucleic acids released into the bloodstream during and after physical exercise. Exerkines liberated from skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (batokines), and neurons (neurokines) may benefit health and wellbeing. Cancer-related cachexia is a highly prevalent disorder characterized by weight loss with specific skeletal muscle and adipose tissue loss. Many studies have sought to provide exercise strategies for managing cachexia, focusing on musculoskeletal tissue changes. Therefore, understanding the responses of musculoskeletal and other tissue exerkines to acute and chronic exercise may provide novel insight and recommendations for physical training to counteract cancer-related cachexia. Methods For the purpose of conducting this study review, we made efforts to gather relevant studies and thoroughly discuss them to create a comprehensive overview. To achieve this, we conducted searches using appropriate keywords in various databases. Studies that were deemed irrelevant to the current research, not available in English, or lacking full-text access were excluded. Nevertheless, it is important to acknowledge the limited amount of research conducted in this specific field. Results In order to obtain a comprehensive understanding of the findings, we prioritized human studies in order to obtain results that closely align with the scope of the present study. However, in instances where human studies were limited or additional analysis was required to draw more robust conclusions, we also incorporated animal studies. Finally, 295 studies, discussed in this review. Conclusion Our understanding of the underlying physiological mechanisms related to the significance of investigating exerkines in cancer cachexia is currently quite basic. Nonetheless, this demonstrated that resistance and aerobic exercise can contribute to the reduction and control of the disease in individuals with cancer cachexia, as well as in survivors, by inducing changes in exerkines.

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Section: Highlighting Exerkines In Cancer Cachexiamentioning

confidence: 99%

Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review

Ahmadi Hekmatikar,

Nelson,

Petersen

2023

BMC Cancer

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Metformin-mediated protection against doxorubicin-induced cardiotoxicity

Sun,

Dong,

Liu

et al. 2024

Biomedicine & Pharmacotherapy

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Novel fluorinated thiazolidin-4-one derivatives: synthesis and anti-cancer potential against HepG2 and HCT116 cell lines

Kadam,

Mammen,

Zunjar

et al. 2024

Aust. J. Chem.

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A novel synthetic route has been designed to introduce fluorine functionality into a series of compounds containing thiazolidin-4-one rings. These compounds were synthesised from various aniline derivatives using a two-step approach: an addition reaction of ethyl isothiocyanate with different aromatic fluorinated anilines, followed by cyclisation to yield the final products. A total of 15 novel fluorinated thiazolidinone compounds were synthesised and characterised using 1H NMR, 19F NMR, Fourier transform–infrared, elemental analysis and liquid chromatography–mass spectrometry. Stereochemistry around the imine bond in the synthesised derivatives was determined using nuclear Overhauser effect spectroscopy. The in vitro anticancer potential of the compounds was tested against two human cancer cell lines, liver (HepG2) and colon (HCT116). The study revealed that the derivatives having fluorine functionality at both the m-positions in the aromatic ring showed promising anticancer potential, as compared to those at o- and p-positions.

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Effect of Metformin on inflammatory markers involved in Cardiotoxicity induced by Doxorubicin

Cited by 11 publications

References 0 publications

Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review

Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review

Metformin-mediated protection against doxorubicin-induced cardiotoxicity

Novel fluorinated thiazolidin-4-one derivatives: synthesis and anti-cancer potential against HepG2 and HCT116 cell lines

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