Effect of Methamphetamine on Cognitive Functions of Adult Female Rats Prenatally Exposed to the Same Drug

Macúchová, Eva; Nohejlová-Deykun, K.; Šlamberová, Romana

doi:10.33549/physiolres.932598

Cited by 19 publications

(10 citation statements)

References 44 publications

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“…Nevertheless, previous investigations have recommended that while the acute use of Meth may enhance memory and attention, chronic use results in reduced memory function ( Seminerio et al, 2013 ). It has been reported that exposure to Meth during preadolescence improves spatial learning in male rats ( Macúchová et al, 2013 ). Surprisingly, clinical studies have also declared that Meth can result in improved learning and memory function, including visuospatial perception and response speed following limited stimulant usage ( Braren et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Meth reduced the intraneuronal oxidative metabolism of dopamine by the repression of monoamine oxidase ( Pereira et al, 2011 ). Also, acute administration of Meth caused an increase in the dopamine level in the nucleus accumbens ( Macúchová et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of Meth abuse, as an escalating public health issue ( Melo et al, 2012 ), has increased dramatically, reaching epidemic proportions worldwide ( Camarasa et al, 2010 ) over the last 20 years ( Moenk and Matuszewich, 2012 ). The universality of this drug can be due to its low price and simple production in comparison with cocaine or heroin ( Macúchová et al, 2013 ). Long-term Meth abuse is linked to ventricular hypertrophy, cardiomyopathies, premature atherosclerosis, and kidney failure ( Melo et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

Etaee

Rezvani-Kamran

Komaki

et al. 2021

Front. Behav. Neurosci.

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Little is known about the effects of methamphetamine (Meth) and buprenorphine (Bup) on memory and learning in rats. The aim of this investigation was to examine the impact of Meth and Bup on memory and learning. Fourteen male Wistar rats weighing 250–300 g were assigned to four groups: Sham, Meth, Bup, and Meth + Bup and were treated for 1 week. Spatial learning and memory, avoidance learning, and locomotion were assessed using the Morris water maze, passive avoidance learning, and open field tests, respectively. Meth and Bup impaired spatial learning and memory in rats. Co-administration of Meth + Bup did not increase the time spent in the target quadrant compared to Meth alone in the MWM. The Bup and Meh + Bup groups were found with an increase in step-through latency (STLr) and a decrease in the time spent in the dark compartment (TDC). Meth and Bup had no effects on locomotor activity in the open field test. Bup showed a beneficial effect on aversive memory. Since Bup demonstrates fewer side effects than other opioid drugs, it may be preferable for the treatment of avoidance memory deficits in patients with Meth addiction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

Etaee

Rezvani-Kamran

Komaki

et al. 2021

Front. Behav. Neurosci.

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“…The average swim path length moved by the rats that received all doses of khat extract and juice subchronically was significantly greater than the rats that received the vehicle. Previous studies indicated that rats that received cocaine (3) and amphetamine (24 & 25) swam longer pathlength compared with control before rats escaped into the hidden platform. Tukey’s test also showed that rats that received the lower dose of extract subchronically had a significantly greater speed than rats that received the middle dose of the extract and vehicle that could be attributed to khat-induced neurochemical alteration.…”

Section: Discussionmentioning

confidence: 99%

Effects ofCatha Edulis Forskon Spatial Cognition and correlation with serum electrolytes in Wild- type Male White Albino Rats

Limenie

Dugul

Makonnen

2021

Preprint

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Background : The burdens of psychostimulant use disorders are becoming a worldwide problem. One of the psychostimulants widely consumed in Ethiopia and East African countries is Catha edulis Forsk (khat). However, no studies have been conducted on the cognitive effects of khat and its correlation with serum electrolytes. The present study was aimed to evaluate the effects of khat on cognitive functions and its correlation with serum electrolytes. Materials and Methods — A total of 36 adult (7-8 weeks) wild-type male Swiss albino rats weighing between 213 and 229g were used in this study. The rats were received crude khat extract subchronically (kesc) (100 mg/kg, 200 mg/kg and 300 mg/kg b.w), khat juice (khJ 2.5 mL/kg) and 2% tween 80 in distilled water (T80W- v/v, vehicle) and khat extract subacutely (kesa) (300 mg/kg). Spatial learning and memory were measured using Morris water maze model and serum electrolytes were measured using Cobas 6000. The data were analyzed using SPSS version 21.0 and Microsoft Excel. Results : Spatial learning was improved with trials across the groups, while average escape latency (s) and swim path-length (cm) of rats that received kesc 200 mg/kg (p<0.001 and p<0.001) and kesc 300 mg/kg (p<0.01 and p<0.001) was significantly greater than rats that received the vehicle. However, there was no significant difference in the latency between rats that received kesa 300mg/kg and vehicle (p>0.05). Thigmotaxis was significantly higher in rats that received all doses of khat extract (p<0.001). The time spent in the target quadrant in rats that received kesc 300 mg/kg was significantly reduced (p<0.05). Serum calcium level was inversely correlated with the escape latency (R=-0.417, p<0.05) in rats that received khat. Conclusions : khat extract and juice administered subchronically, but not subacute administration, impaired learning and memory in rats and was associated with serum calcium reduction. The neuronal basis for such alteration should be investigated.

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“…Experimental studies have described various sequelae related to prenatal MA exposure. Our previous studies have demonstrated that prenatal drug exposure can impair sensorimotor development ( Šlamberová et al, 2006 ; Holubová et al, 2017 ) as well as the development of the central nervous system of rat pups and induce various psychological impairments ( Šlamberová, 2012 ; Macúchová et al, 2013 ). Although it was shown that prenatal MA exposure could induce changes affecting behavior during the preweaning period, these changes did not seem to persist into adulthood ( Hrubá et al, 2010 , 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Perinatal Stress and Methamphetamine Exposure Decreases Anxiety-Like Behavior in Adult Male Rats

Holubová-Kroupová

Šlamberová

2021

Front. Behav. Neurosci.

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Methamphetamine (MA) is an illicit synthetic psychostimulant drug, and its abuse is growing worldwide. MA has been reported as the primary drug of choice, by drug-abusing women, during pregnancy. Since MA easily crosses the placental barrier, the fetus is exposed to MA in a similar fashion to the mother. This study aimed to evaluate the effect of long-term perinatal stressors and drug exposure on anxiety-like behavior in adult male rats using the open field test (OF) and elevated plus maze (EPM). Dams were divided into three groups according to drug treatment during pregnancy: controls (C), saline—SA [subcutaneous (s.c.), 1 ml/kg], and MA (s.c., 5 mg/kg). Litters were divided into four groups according to postnatal stressors: non-stressed controls (N), maternal separation (S), maternal cold water stress (W), and maternal separation plus maternal cold water stress (SW). Forty-five minutes before testing (in both OF and EPM), one-half of adult male rats received an (s.c.) injection of MA and the other half received an SA injection. Prenatal MA/stress exposure did not affect anxiety-like behavior in adult male rats in both tests. In the OF, an acute MA dose in adulthood increased the time spent in the central disk area, decreased time spent in the corners, and decreased time spent immobile and grooming. Also, postnatal stress increased time spent in the central disk area, decreased time spent in corners, and increased mobility compared to controls. All groups of rats exposed to postnatal stressors spent significantly less time in the closed arms of the EPM compared to controls. Overall, our results indicate that early postnatal stress and a single acute MA administration in adulthood decreases the parameters of anxiety-like behavior in adult male rats regardless of prenatal MA exposure. Moreover, postnatal stress via maternal separation impacts the effect of acute MA administration in adulthood. Long-term postnatal stress may thus result in improved adaptation to subsequent stressful experiences later in life.

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Effect of Methamphetamine on Cognitive Functions of Adult Female Rats Prenatally Exposed to the Same Drug

Cited by 19 publications

References 44 publications

Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

Effects ofCatha Edulis Forskon Spatial Cognition and correlation with serum electrolytes in Wild- type Male White Albino Rats

Perinatal Stress and Methamphetamine Exposure Decreases Anxiety-Like Behavior in Adult Male Rats

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