Effect of methomyl on sex steroid hormone and vitellogenin levels in serum of male tilapia (<i>Oreochromis niloticus</i>
) and recovery pattern

Meng, Shunlong; Qiu, Liping; Hu, Gengdong; Fan, Limin; Song, Chao; Zheng, Yao; Wu, Wei; Jianhong, Qu; Li, Dandan; Chen, Jiazhang; Xu, Pao

doi:10.1002/tox.22409

Cited by 20 publications

(6 citation statements)

References 71 publications

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“…Because of its high solubility in water (57.9 g L −1 at 25 • C) and only weak to moderate adsorption in soils, methomyl has been detected in surface waters and food crops [1], with residues as high as 55.3 µg L −1 reported in environmental water [2]. Owing to its frequent detection in natural water bodies and its endocrine disruption potential in animals [3], the toxicity of methomyl to aquatic animals has attracted considerable attention [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Exposure to Pesticide Methomyl on Antioxidant Defense System in Testis of Tilapia (Oreochromis niloticus) and Its Recovery Pattern

et al. 2021

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The chronic effect of environmental methomyl on the antioxidant system in testis of Nile tilapia (Oreochromis niloticus) and its recovery pattern was investigated. Tilapia were exposed to sublethal concentrations of 0.2, 2, 20 and 200 μgL−1 methomyl for 30 days and thereafter moved to methomyl-free water for 18 days. Antioxidant levels in testis, including glutathione peroxidase, catalase, glutathione-S-transferase, glutathione reductase, superoxide dismutase, reduced glutathione, oxidized glutathione were measured every 6 days during the period of exposure, and at 18 days after being transferred to methomyl-free water. The results showed that lower methomyl concentration (0.2 μgL−1) had no effect on the above antioxidants, thus 0.2 μgL−1 could be seen as NOAEL for methomyl to tilapia. However, higher methomyl concentration of 2, 20 and 200 μgL−1 could significantly influence the above antioxidants. Glutathione peroxidase and oxidized glutathione increased significantly. On the contrary, reduced glutathione decreased significantly. Catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase increased at lower methomyl (2 and 20 μgL−1), but decreased at higher methomyl (200 μgL−1). The recovery test showed that oxidative damage caused by lower methomyl of 2 and 20 μgL−1 was reversible, and oxidative damage caused by higher methomyl of 200 μgL−1 was irreversible within 18 days of recovery period.

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Section: Introductionmentioning

confidence: 99%

Effect of Chronic Exposure to Pesticide Methomyl on Antioxidant Defense System in Testis of Tilapia (Oreochromis niloticus) and Its Recovery Pattern

et al. 2021

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“…Sohoni et al [ 68 ] reported inhibition of both gonadal and somatic growth (weight and length) in males fathead minnows exposed to BPA concentrations of 640 and 1280 μg/L. GSI was significantly lower in mature carp naturally exposed to BPA from a highly polluted site and in O. niloticus exposed to 200 µg/L methomyl [ 62 , 69 ]. In the present study, the K-factor showed no conspicuous trend over months; however, it was declined in August and still at the same level in October.…”

Section: Discussionmentioning

confidence: 99%

Multiple Xenosteroid Pollutants Biomarker Changes in Cultured Nile Tilapia Using Wastewater Effluents as Their Primary Water Source

Zahran

Elmetwally

Awadin

et al. 2020

Animals

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This study was undertaken to screen levels of xenosteroids (estrogenic endocrine disrupting chemicals/E-EDCs) in Nile tilapia (Oreochromis niloticus) fish farms subjected to water fill from the drain at three sites S1 (highly polluted), S2 (moderately polluted), and a putative reference site (RS). Biometric, hormonal, gene expression, and histopathological analysis were investigated. Testosterone, progesterone, and zeranol residues were detected at (0.12–3.44 µg/L) in water samples of different sites. Bisphenol-A (BPA) exhibited a very high concentration (6.5 µg/mL) in water samples from S1. Testosterone, 17β-estradiol residues were detected in fish tissues from all sites at (0.16–3.8 µg/Kg) and (1.05–5.01 µg/Kg), respectively. BPA residues were detected at a very high concentration in the liver and muscle of fish collected from S1 at higher levels of 25.9 and 48.07 µg/Kg, respectively. The detected E-EDCs, at different sites, particularly BPA, reduced the somatic and testicular growth among sites and oversampling time points. Meanwhile, hepatosomatic index (HSI) was significantly increased in S1 compared to S2. All analyzed genes estrogen receptor-type I (er-I, er-ɑ) and II (er-II, er-ß1), polypeptide 1a (cyp19a1), SRY-box containing gene 9 (sox9), and vitellogenin (vtg) and gonadotropin hormones (luteinizing hormone (LH), follicle-stimulating hormone (FSH)), testosterone, 17β-estradiol, and anti-Mullerian hormone (AMH) were significantly expressed at S1 compared to other sites. Histopathology was more evident in S1 than other sites. These findings warrant immediate strategies development to control aquatic pollution and maintain fish welfare and aquaculture sustainability.

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“…The toxicological impacts of methomyl on aquatic animals, amphibians, land mammals, and humans are presented in Table 1. Reduction in the efficiency of the food chain in a Cr/Dg system [34] Different aspects of methomyl toxicity on tilapia as a model aquatic organism have been studied [15,35,36]. A high concentration of methomyl was found to drastically change biochemical and histological activities in tilapia.…”

Section: Toxicological Effects Of Methomyl Insecticidesmentioning

confidence: 99%

“…Environmental residues of methomyl can affect non-target organisms through the air, water, soil, and food chain ( Figure 2). Long-term exposure to methomyl can result in hepatotoxicity, cytotoxicity, and neurotoxicity in animals [15][16][17]. According to a survey conducted in France, 4.2% of the population was directly or indirectly poisoned with methomyl during the period 2012-2016 [18].…”

Section: Introductionmentioning

confidence: 99%

Current Approaches to and Future Perspectives on Methomyl Degradation in Contaminated Soil/Water Environments

et al. 2020

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Methomyl is a broad-spectrum oxime carbamate commonly used to control arthropods, nematodes, flies, and crop pests. However, extensive use of this pesticide in agricultural practices has led to environmental toxicity and human health issues. Oxidation, incineration, adsorption, and microbial degradation methods have been developed to remove insecticidal residues from soil/water environments. Compared with physicochemical methods, biodegradation is considered to be a cost-effective and ecofriendly approach to the removal of pesticide residues. Therefore, micro-organisms have become a key component of the degradation and detoxification of methomyl through catabolic pathways and genetic determinants. Several species of methomyl-degrading bacteria have been isolated and characterized, including Paracoccus, Pseudomonas, Aminobacter, Flavobacterium, Alcaligenes, Bacillus, Serratia, Novosphingobium, and Trametes. The degradation pathways of methomyl and the fate of several metabolites have been investigated. Further in-depth studies based on molecular biology and genetics are needed to elaborate their role in the evolution of novel catabolic pathways and the microbial degradation of methomyl. In this review, we highlight the mechanism of microbial degradation of methomyl along with metabolic pathways and genes/enzymes of different genera.

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Effect of methomyl on sex steroid hormone and vitellogenin levels in serum of male tilapia (Oreochromis niloticus ) and recovery pattern

Cited by 20 publications

References 71 publications

Effect of Chronic Exposure to Pesticide Methomyl on Antioxidant Defense System in Testis of Tilapia (Oreochromis niloticus) and Its Recovery Pattern

Effect of Chronic Exposure to Pesticide Methomyl on Antioxidant Defense System in Testis of Tilapia (Oreochromis niloticus) and Its Recovery Pattern

Multiple Xenosteroid Pollutants Biomarker Changes in Cultured Nile Tilapia Using Wastewater Effluents as Their Primary Water Source

Current Approaches to and Future Perspectives on Methomyl Degradation in Contaminated Soil/Water Environments

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