Effect of Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Patients with Nail Psoriasis

Krajewska–Włodarczyk, Magdalena; Owczarczyk‐Saczonek, Agnieszka; Placek, Waldemar; Wojtkiewicz, Maja; Wojtkiewicz, Joanna

doi:10.3390/jcm7120546

Cited by 12 publications

(11 citation statements)

References 30 publications

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“…The related report indicated that one of the pathogeneses of psoriasis is hypernomic activation of toll-like receptors in dendritic cells, which is basically believed to be crucial in initiating an immune response (Meng et al, 2017). To date, most studies have investigated feasible treatments for the disease, which may require the fundamental role for short-term improvement and long-term control, but there is no standardized therapeutic regimen for psoriasis and is incapable of resulting in the complete clearing of psoriasis (Al-Suwaidan and Feldman, 2000;Naldi et al, 2003;Krajewska-Wlodarczyk et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Profiling Reveals the Amelioration Effect of Methotrexate on Imiquimod-Induced Psoriasis in Mouse

Zong

Cheng

et al. 2020

Front. Pharmacol.

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Background: The imiquimod (IMQ)-induced psoriasis mouse model has been used as a model for pathogenic mechanism research, and methotrexate (MTX) is widely employed to treat various clinical manifestations of psoriasis. We explored the underlying pathogenesis of psoriasis and the treatment mechanism of the conventional drugs from the metabolic perspective of the psoriasis mouse model. Methods: Male BALB/c mice were smeared IMQ for 7 days to induce treatment-resistant psoriasis and intragastrically administered 1 mg/kg MTX. We evaluated inflammation of psoriasis-like lesions and therapeutic effects of MTX based on histological changes and immunohistochemistry. Based on gas chromatography-mass spectrometer detection of serum samples, a comprehensive metabolomics analysis was carried out to identify alterations of metabolites. Results: It was found that MTX ameliorated psoriatic lesions (representative erythema, scaling, and thickening) by inhibiting proliferation and differentiation of keratinocytes. Using multivariate statistical analysis to process metabolomics data, the results displayed alterations in serum metabolites among mice of the control group, IMQ group, and MTX group. Compared with group, psoriasis mice had the higher level of d-galactose and lower expression of myo-inositol, 9,12-octadecadienoic acid, and cholesterol. In contrast with the model set, serum levels of glycine, pyrrolidone carboxylic acid, d-galactose, and d-mannose were significantly decreased in the MTX group. Conclusion: The differential metabolites, reflecting the perturbation in the pathways of inositol phosphate metabolism; galactose metabolism; glyoxylate and dicarboxylate metabolism; glycine, serine, and threonine metabolism; and glutathione metabolism, may lead to the pathogenesis of psoriasis, and they are also related to the pharmacological treatment effect of MTX on psoriasis. This study established the foundation for further research on the mechanism and therapeutic targets of psoriasis.

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Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Profiling Reveals the Amelioration Effect of Methotrexate on Imiquimod-Induced Psoriasis in Mouse

Zong

Cheng

et al. 2020

Front. Pharmacol.

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“…In a third study, patients with psoriasis ( n = 19) and psoriatic arthritis ( n = 13) were evaluated for morphologic changes in DIP extensor tendon enthesopathy on ultrasound before and after treatment with methotrexate. After 6 months of treatment, methotrexate resulted in a decrease in extensor tendon thickness in patients with psoriasis but not in those with psoriatic arthritis 33 …”

Section: Resultsmentioning

confidence: 91%

“…In the study by Savage et al., ustekinumab treatment resulted in the resolution of ultrasound‐diagnosed enthesitis in 62% of patients at 52 weeks 23 . Similarly, in a study by Krajewska‐Włodarczyk et al., 6 months of treatment with methotrexate resulted in a reduction in DIP extensor tendon thickness in psoriasis patients, but this effect was not seen in patients with psoriatic arthritis 33 . These findings suggest that there may be a brief window of time to proactively treat psoriasis patients with subclinical enthesitis, which may affect clinical outcomes and future disease progression.…”

Section: Discussionmentioning

confidence: 94%

The use of ultrasound to detect enthesitis as a potential guide for intervention in patients with psoriasis at risk of psoriatic arthritis: a systematic review

et al. 2023

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Introduction Psoriatic arthritis is estimated to develop in 2% of patients with psoriasis per year and can result in significant morbidity. Early diagnosis and treatment of psoriatic arthritis are imperative to prevent irreversible arthritic joint damage. Dermatologists play a key role in identifying patients who are at risk for or with early signs of psoriatic arthritis. Subclinical enthesopathy may be a risk factor for psoriatic arthritis or an early sign of the disease and can be detected using ultrasound.Methods In this systematic review, we determined the prevalence of ultrasound-diagnosed enthesitis in psoriasis patients, as well as their risk of subsequent progression to psoriatic arthritis. ResultsWe determined that the detection of enthesitis on ultrasound was associated with higher risk of future psoriatic arthritis. Systemic therapy was associated with improvement in enthesitis findings in patients with psoriasis but not in those with chronic structural damage or established psoriatic arthritis. Additionally, one study showed that ustekinumab treatment resulted in a significantly lower rate of psoriatic arthritis development.Conclusions These studies support the value of early detection and treatment in the prevention of progression to psoriatic arthritis, as well as the use of ultrasound for screening for risk factors in psoriasis patients. Future studies are needed to further evaluate when preventative therapy can be useful among patients with psoriasis with risk factors for psoriatic arthritis.

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“…A total of 753 articles were screened and 67 articles included, as depicted in the PRISMA flow diagram in Figure 1 9‐75 . The number of articles per technique varied substantially, ranging from 36 for US to just one on PET/CT.…”

Section: Resultsmentioning

confidence: 99%

Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology

Ortner

Mandel

Bertugno

et al. 2022

Experimental Dermatology

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Background The growing interest in the visualization of psoriatic nail unit changes has led to the discovery of an abundance of image characteristics across various modalities. Objective To identify techniques for non‐invasive imaging of nail unit structures in psoriatic patients and review extracted image features to unify the diverse terminology. Methods For this systematic scoping review, we included studies available on PubMed and Embase, independently extracted image characteristics, and semantically grouped the identified features to suggest a preferred terminology for each technique. Results After screening 753 studies, 67 articles on the visualization of clinical and subclinical psoriatic changes in the nail plate, matrix, bed, folds and hyponychium were included. We identified 4 optical and 3 radiological imaging techniques for the assessment of surface (dermoscopy [n = 16], capillaroscopy [n = 12]), sub‐surface (ultrasound imaging [n = 36], optical coherence tomography [n = 4], fluorescence optical imaging [n = 3]), and deep‐seated psoriatic changes (magnetic resonance imaging [n = 2], positron emission tomography‐computed tomography [n = 1]). By condensing 244 image feature descriptions into a glossary of 82 terms, overall redundancy was cut by 66.4% (37.5%–77.1%). More than 75% of these image features provide additional disease‐relevant information that is not captured using conventional clinical assessment scales. Conclusions This review has identified, unified, and contextualized image features and related terminology for non‐invasive imaging of the nail unit in patients with psoriatic conditions. The suggested glossary could facilitate the integrative use of non‐invasive imaging techniques for the detailed examination of psoriatic nail unit structures in research and clinical practice.

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Effect of Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Patients with Nail Psoriasis

Cited by 12 publications

References 30 publications

Serum Metabolomic Profiling Reveals the Amelioration Effect of Methotrexate on Imiquimod-Induced Psoriasis in Mouse

Serum Metabolomic Profiling Reveals the Amelioration Effect of Methotrexate on Imiquimod-Induced Psoriasis in Mouse

The use of ultrasound to detect enthesitis as a potential guide for intervention in patients with psoriasis at risk of psoriatic arthritis: a systematic review

Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology

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