Abstract:We report here a hydrophobic ionic liquid (IL), 1-butyl-1-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (P14-TFSI), that contributed to increasing the amount of production of paclitaxel and the related taxanes of 10-deacetyl baccatin III, baccatin III and cepharomannine with in situ extraction from an aqueous medium in the IL-medium two phase culture system. Addition of an elicitor, methyl jasmonate (MJ) to the cell culture system enhanced the amount of production of the taxanes in the culture includi… Show more
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