Effect of methylene blue on estrogen-receptor activity.

Ji, Hirsch; Wl, Banks; Js, Sullivan; Js, Horsley

doi:10.1148/radiology.171.1.2467322

Cited by 14 publications

(6 citation statements)

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“…There has been an isolated report by Hirsch et al. (45) on the influence of MB in altering the estrogen receptor assay. However, this has not been our experience with any other studies indicating the same.…”

Section: Discussionmentioning

confidence: 99%

Methylene Blue Dye-A Safe and Effective Alternative for Sentinel Lymph Node Localization

et al. 2008

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Sentinel lymph node (SLN) biopsy has emerged as an effective diagnostic tool in axillary staging in breast cancer. The commonly used technique employs isosulfan blue/patent blue V combined with radioactive colloid tracer. Methylene blue (MB) is a less expensive and readily available alternative dye. The study evaluated the safety and efficacy of MB in SLN localization. A retrospective study of 329 patients with early breast cancer who had SLN localization as part of an ethically approved prospective evaluation study of SLN localization technique was carried out. Lymph node positive, tumors >2 cm on clinical and radiological evaluation, those with previous breast and axillary surgery, neo-adjuvant chemotherapy were excluded from the study. One hundred seventy three patients underwent SLN localization using 1 mL of 1% MB, and a combined MB-radio colloid tracer technique was used in the other 156 patients. Allocation to the groups was by simple randomization. Injection of the dye and radioisotope was into the subdermal plane in the sub-areolar region. Patients underwent breast conservation surgery or mastectomy with SLN directed four node axillary sampling +/- axillary clearance. The lymph node was examined by standard microscopy. There were no reported complications with the use of MB aside from temporary tattooing. The technique failed in eight patients giving an identification rate of 97.6%. Ten of the 258 (3.9%) patients had false-negative SLN, with negative predictive value of 96.1%, sensitivity of predicting further axillary disease of 73%, specificity of 87.3%, and overall accuracy of 85.7%. Reported adverse reaction to isosulfan blue/patent blue V varied from minor to severe anaphylactic reactions (1-3%) requiring vigorous resuscitation. Subdermal sub-areolar injection of MB is safe and effective readily available dye for SLN localization in axillary staging of breast cancer with no major adverse reaction.

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Section: Discussionmentioning

confidence: 99%

Methylene Blue Dye-A Safe and Effective Alternative for Sentinel Lymph Node Localization

et al. 2008

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“…Similar to thyroid hormone, the actions of estrogens are also modulated by MB (Hirsch et al, 1989). Estradiol-induced adenohypophyseal enlargement and the enhancement of prolactin secretion are antagonized by MB (Nedvídkova et al, 2000; 2001).…”

Section: Methylene Blue and The Neuroendocrine Systemmentioning

confidence: 99%

Cellular and molecular actions of Methylene Blue in the nervous system

Öz

Lorke

Al‐Hasan

et al. 2010

Medicinal Research Reviews

359

249

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Methylene Blue (MB), following its introduction to biology in the 19 th century by Ehrlich, has found uses in various areas of medicine and biology. At present, MB is the first line of treatment in methemoglobinemias, is used frequently in the treatment of ifosfamide-induced encephalopathy, and is routinely employed as a diagnostic tool in surgical procedures. Furthermore, recent studies suggest that MB has beneficial effects in Alzheimer's disease and memory improvement. Although the modulation of the cGMP pathway is considered the most significant effect of MB, mediating its pharmacological actions, recent studies indicate that it has multiple cellular and molecular targets. In the majority of cases, biological effects and clinical applications of MB are dictated by its unique physicochemical properties including its planar structure, redox chemistry, ionic charges, and light spectrum characteristics. In this review article, these physicochemical features and the actions of MB on multiple cellular and molecular targets are discussed with regard to their relevance to the nervous system.

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“…Although dyes have been used for localization of nonpalpable lesions [2][3][4], needle wires are most often used for this purpose [5][6][7][8][9][10] because the surgeon can accurately localize the lesion and perform reliable excision. Several types of wires have been developed, and they differ mainly in the shape of the distal anchor and ease of repositioning.…”

Section: Mariscal Martínez Et Almentioning

confidence: 99%

“…In techniques performed with methylene blue dye, one of the most extensively used coloring agents, the interval between localization of the lesion and surgery is necessarily short. Diffusion of the dye throughout the breast occurs in a few hours and, after that time, the lesion cannot be seen [2]. In another localization technique, an aqueous suspension of 4% carbon is used alone or in combination with wire insertion.…”

mentioning

confidence: 99%