Effect of metoclopramide on interdigestive myoelectric activity in the conscious dog

Wingate, David; Pearce, Elizabeth; Hutton, M.; Ling, Anne

doi:10.1007/bf01312727

Cited by 13 publications

(2 citation statements)

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“…In nonfed dogs , metoclopramide shortened phase I and enhanced the electrical activity associated with phases II and III of the MMC , without disrupting the nonfed pattern. 24 Its effects in healthy dogs were variable and not dose dependent. 24 The effect of metoclopramide on electrical and contractile activities of the stomach in nonfed dogs were not assessed in our study .…”

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Effect of metoclopramide on fed-state gastric myoelectric and motor activity in dogs

Hall,

Solie,

Seim

et al. 1996

ajvr

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Objective To investigate the effects of metoclopramide, a putative gastroprokinetic agent, on dogs that had recovered from gastric dilatation-volvulus (GDV), a disorder characterized by delayed gastric emptying. Animals 6 healthy dogs and 5 dogs after treatment and recovery from GDV. Procedure Baseline recordings of gastric electrical and contractile activities were made 8 or 10 days after circumcostal gastropexy and implantation of serosal electrodes and strain-gauge force transducers. Gastric activities were recorded again the next day after treatment with the clinically recommended oral metoclopramide dose (0.3 mg/kg of body weight) administered a half hour before feeding. Recordings were analyzed to determine gastric slow-wave frequency, presence of slow-wave dysrhythmia, slow-wave propagation velocity, coupling of contractions to slow waves, a motility index based on relative contractile amplitudes, and onset of contractions after a standardized meal. Results Significant differences in gastric electrical or contractile activities were not detected after metoclopramide treatment in dogs with GDV. Compared with control dogs after metoclopramide treatment, gastric slow-wave propagation velocity was significantly (P = 0.03) faster for the dogs with GDV at postprandial minute 90. Conclusion At a clinically recommended dosage, metoclopramide treatment did not change gastric myoelectric and motor activities in a way that would promote increased gastric emptying in dogs with GDV. Clinical Relevance Metoclopramide treatment may not benefit dogs with GDV and delayed gastric emptying. (Am J Vet Res 1996;57:1616–1622)

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“…24 Its effects in healthy dogs were variable and not dose dependent. 24 The effect of metoclopramide on electrical and contractile activities of the stomach in nonfed dogs were not assessed in our study .…”

mentioning

confidence: 99%