Effect of Metoclopramide Therapy on Arginine Vasopressin Excretion and Renal Water Handling in Premature Infants

Sulyok, E.; Kovács, L; Lichardus, B; Bircák, J

doi:10.1159/000242623

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…After metoclopramide ad ministration there was a significant fall in urinary AVP excretion indicating that, con trary to adults, in low birth weight prema ture infants endogenous dopamine enhances rather than inhibits pituitary AVP secretion. Increased dopaminergic activity in sodiumdepleted, hyponatrémie premature infants may contribute, therefore, to restore the vol ume of body fluid compartments through stimulating AVP release [33].…”

Section: Observations In Human Neonatesmentioning

confidence: 99%

Renal Response to Vasopressin in Premature Infants: What Is New?

Sulyok¹

1988

Neonatology

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Clinical and experimental data indicate that the neonatal pituitary is capable of responding with arginine vasopressin (AVP) release to physiological stimulation and pathological events commonly seen in the perinatal period. The limited concentrating performance of the newborn kidney is thought, therefore, to be accounted for by the diminished end-organ responsiveness to AVP and the inability of the immature kidney to generate and maintain deep corticopapillary osmotic gradient. Evidence has been provided to indicate that in low birth weight premature infants the impaired renal tubular sodium transport, the renal salt wasting and late hyponatremia, and the increased renal prostaglandin production may be important factors in attenuating renal response to AVP.

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Section: Observations In Human Neonatesmentioning

confidence: 99%

Renal Response to Vasopressin in Premature Infants: What Is New?

Sulyok¹

1988

Neonatology

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“…D 1 dopamine receptor; sodium-hydrogen exchanger 3; G␤/␥ subunit; renal proximal tubules; ontogeny THE DECREASED NATRIURETIC effect of dopamine and dopamine agonists in the young of many species, including humans, is well documented (24,26,32,34,35). The decreased natriuretic effect of dopamine is caused by impaired inhibition of sodium reabsorption via D 1 -like receptors and activation of sodium reabsorption via ␣-adrenergic and D 2 -like receptors (13,15,26,32,35,36). The impaired action of D 1 -like receptors in the young is caused by both decreased renal vasodilatory and tubular effects (13).…”

mentioning

confidence: 99%

Gβ regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development

Albrecht

Robillard

et al. 2000

American Journal of Physiology-Regulatory, Integrative and Comp

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The decreased natriuretic action of dopamine in the young has been attributed to decreased generation of cAMP by the activated renal D(1)-like receptor. However, sodium/hydrogen exchanger (NHE) 3 activity in renal brush-border membrane vesicles (BBMV) can be modulated independent of cytoplasmic second messengers. We therefore studied D(1)-like receptor regulation of NHE activity in BBMVs in 2-, 4-, and 12-wk-old (adult) rats. Basal NHE activity was least in 2-wk-old compared with 4- and 12-wk-old rats. D(1)-like agonist (SKF-81297) inhibition of NHE activity was also least in 2-wk-old (-1 +/- 9%, n = 3) compared with 4 (-15 +/- 5%, n = 6)- and 12 (-65 +/- 4%, n = 6)-wk-old rats. The decreased response to the D(1)-like agonist in BBMV was not caused by decreased D(1) receptors or NHE3 expression in the young. G(s)alpha, which inhibits NHE3 activity by itself, coimmunoprecipitated with NHE3 to the same extent in 2-wk-old and adult rats. G(s)alpha function was also not impaired in the young because guanosine 5'-O-(3-thiotriphosphate) decreased NHE activity to a similar extent in 4-wk-old and adult rats. Galpha(i-3) protein expression in BBMV also did not change with age. In contrast, Gbeta expression and the amount of Gbeta that coimmunoprecipitated with NHE3 in BBMV was greatest in 2-wk-old rats and decreased with age. Gbeta common antibodies did not affect D(1)-like agonist inhibition of NHE activity in adult rats (8%) but markedly increased it (48%)in 4-wk-old rats. We conclude that the decreased inhibitory effect of D(1)-like receptors on NHE activity in BBMV in young rats is caused, in part, by the increased expression and activity of the G protein subunit Gbeta/gamma. The direct regulation of NHE activity by G protein subunits may be an important step in the maturation of renal tubular ion transport.

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Dopaminergic control of neonatal salt and water metabolism

Sulyok¹

1988

Pediatr Nephrol

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There is reason to believe that the dopaminergic system plays a role in the control of salt and water metabolism in the neonate. Therefore, we performed a series of studies designed to test this assumption and reveal the relationship between dopamine (DA) and other factors known to affect salt and water balance. The postnatal course of urinary dopamine excretion was assessed in a group of premature infants kept on low or high salt diet. A clear association between sodium depletion and increased DA excretion, and between reduction in DA excretion and restoration of salt balance was demonstrated. In premature infants with cardiopulmonary distress, DA therapy resulted in an increase in sodium and water diuresis, enhanced plasma renin activity (PRA) and decreased plasma prolactin level; the plasma aldosterone (pAldo) level remained stable. Metoclopramide (MTC), a specific DA antagonist given to premature infants to treat functional gastrointestinal disturbances, induced an increase in Na+ and water excretion which was associated with significant falls in plasma and urinary aldosterone, but left PRA unaltered. Arginine vasopressin excretion also fell after MTC, but this change was not associated with increased free water clearance. These results suggest that endogenous DA has no apparent influence on PRA and, contrary to findings in adults, it stimulates the secretion of aldosterone and vasopressin and thus tubular sodium and water reabsorption.

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Effect of Metoclopramide Therapy on Arginine Vasopressin Excretion and Renal Water Handling in Premature Infants

Cited by 4 publications

References 8 publications

Renal Response to Vasopressin in Premature Infants: What Is New?

Renal Response to Vasopressin in Premature Infants: What Is New?

Gβ regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development

Dopaminergic control of neonatal salt and water metabolism

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