Effect of Metofluthrin-Impregnated Spatial Repellent Devices Combined with New Long-Lasting Insecticidal Nets (Olyset&lt;sup&gt;®&lt;/sup&gt; Plus) on Pyrethroid-Resistant Malaria Vectors and Malaria Prevalence: Field Trial in South-Eastern Malawi

Kawada, Hiroyuki; Nakazawa, Shozo; Shimabukuro, Kozue; Ohashi, Kazunori; Kambewa, Eggrey Aisha; Pemba, Dylo

doi:10.7883/yoken.jjid.2019.311

Cited by 8 publications

(16 citation statements)

References 24 publications

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“…negatively affecting the development of Plasmodium parasites (23). We have shown that the combinational use of LLIN (Olyset ® Plus) and the MSRD with two strips per 10 m 2 at threemonth intervals reduced the vector mosquito density in the field test results performed in the present trial sites in Malawi, where more than half of the houses were rural African-type thatched-roof houses (11). Thatched-roof houses which encompass the majority of houses in the rural African area, have a higher probability of mosquito infestation, but the vaporization of metofluthrin from the MSRD is also higher in such a house structure due to indoor air flow, resulting in a reduction in mosquito numbers.…”

Section: Accepted Manuscriptmentioning

confidence: 55%

“…The intervention reduced the infection rate in children as well as the number of pyrethroid-resistant vector mosquitoes invading in houses. We concluded in the above study that continued intervention using MSRD at 3month intervals with 2 strips per 10 m 2 to reduce the density of malaria mosquitoes was recommended in order to effective malaria control (11).…”

Section: Accepted Manuscriptmentioning

confidence: 91%

“…Metofluthrin-impregnated spatial repellent devices (MSRD) have been suggested to be practically effective in preventing mosquito blood feeding in several regions with different conditions (4)(5)(6)(7)(8)(9). MSRD has also been reported to be highly effective in repelling pyrethroid-resistant malaria vector mosquitoes in Kenya (10) and Malawi (11). We examined the effect of the combinational use of the MSRD and the long lasting insecticidal net, LLIN (Olyset ® Plus) on malaria prevalence and vector mosquitoes in malaria endemic villages in south-eastern Malawi.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…arabiensis and An. funestus s.s. in the study site (11). Most of the houses in the study area were built of mud bricks, some of…”

Section: Study Area and Housesmentioning

confidence: 99%

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Effects of Indoor Environmental Factors and House Structures on Vaporization of Active Ingredient from Spatial Repellent Devices in Rural Houses in Malawi

et al. 2022

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The use of a metofluthrin-impregnated spatial repellent device (MSRD) is a new, practically effective method for preventing mosquito blood feeding. Indoor environmental factors such as room temperature and ventilation rate are thought to be important for MSRD activity. Measurements of room temperature and vaporization of metofluthrin from MSRD in typical rural metal-roof houses and thatched-roof houses in southeastern Malawi were conducted. The relationship between house structure and number of collected Anopheline mosquitoes with and without MSRD treatment was also investigated.The difference between daytime room temperature and nighttime room temperature was significantly higher in metal-roof houses than thatched-roof houses. The vaporization of metofluthrin from the MSRD was not accelerated by the high room temperature, but by the high indoor air flow by ventilation. The number of mosquito collections was significantly higher in thatched-roof houses than in metal-roof houses. MSRD-treated thatched-roof houses have a higher probability of mosquito infestation, but the vaporization of metofluthrin is also higher due to indoor air flow, resulting in a reduction in mosquito numbers. Metal-roof houses with closed eaves reduce the probability of mosquito invasion, and a longer predicted effectiveness occurs with MSRD because of the controlled release of metofluthrin through lower indoor air flow.

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Section: Accepted Manuscriptmentioning

confidence: 55%

Section: Accepted Manuscriptmentioning

confidence: 91%

Section: Accepted Manuscriptmentioning

confidence: 99%

“…arabiensis and An. funestus s.s. in the study site (11). Most of the houses in the study area were built of mud bricks, some of…”

Section: Study Area and Housesmentioning

confidence: 99%

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Effects of Indoor Environmental Factors and House Structures on Vaporization of Active Ingredient from Spatial Repellent Devices in Rural Houses in Malawi

et al. 2022

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“…SRs can be employed in a variety of devices. They can be actively emitted using coils or electric diffusers [18], or they can be passively emitted from a surface impregnated with the AS [26,37,38]. A commonality of the previously cited studies is that they diffused volatile pyrethroids directly into the air.…”

Section: Discussionmentioning

confidence: 99%

To Kill or to Repel Mosquitoes? Exploring Two Strategies for Protecting Humans and Reducing Vector-Borne Disease Risks by Using Pyrethroids as Spatial Repellents

Moreno-Gómez¹,

Miranda

Bueno-Marí

2021

Pathogens

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Although control efforts are improving, vector-borne diseases remain a global public health challenge. There is a need to shift vector control paradigms while developing new products and programmes. The importance of modifying vector behaviour has been recognised for decades but has received limited attention from the public health community. This study aims to: (1) explore how the use of spatial repellents at sublethal doses could promote public health worldwide; (2) propose new methods for evaluating insecticides for use by the general public; and (3) identify key issues to address before spatial repellents can be adopted as complementary vector control tools. Two field experiments were performed to assess the effects of an insecticidal compound, the pyrethroid transfluthrin, on Aedes albopictus mosquitoes. The first examined levels of human protection, and the second looked at mosquito knockdown and mortality. For the same transfluthrin dose and application method, the percent protection remained high (>80%) at 5 h even though mosquito mortality had declined to zero at 1 h. This result underscores that it matters which evaluation parameters are chosen. If the overarching goal is to decrease health risks, sublethal doses could be useful as they protect human hosts even when mosquito mortality is null.

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Pesticide Resistance

Kasai,

Hashimoto

2024

Entomology Monographs

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Effect of Metofluthrin-Impregnated Spatial Repellent Devices Combined with New Long-Lasting Insecticidal Nets (Olyset<sup>®</sup> Plus) on Pyrethroid-Resistant Malaria Vectors and Malaria Prevalence: Field Trial in South-Eastern Malawi

Cited by 8 publications

References 24 publications

Effects of Indoor Environmental Factors and House Structures on Vaporization of Active Ingredient from Spatial Repellent Devices in Rural Houses in Malawi

Effects of Indoor Environmental Factors and House Structures on Vaporization of Active Ingredient from Spatial Repellent Devices in Rural Houses in Malawi

To Kill or to Repel Mosquitoes? Exploring Two Strategies for Protecting Humans and Reducing Vector-Borne Disease Risks by Using Pyrethroids as Spatial Repellents

Pesticide Resistance

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