Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: A placebo-controlled, double-blind study

Morales, Walter J.; Schorr, S J; Albritton, John

doi:10.1016/s0002-9378(94)70033-8

Cited by 315 publications

(174 citation statements)

References 15 publications

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“…79 Treatment of bacterial vaginosis with oral metronidazole in patients with prior preterm birth has been shown to reduce prematurity (18% vs 39%) and premature rupture of membranes (5% vs 33%). 80 Furthermore, antibiotic treatment including tetracycline, erythromycin, and clindamycin has been shown to increase newborn weight among treated mother-infant pairs. 81 This may reflect treatment of ureaplasma urealyticum rather than bacterial vaginosis.…”

Section: Bacterial Vaginosis Pathologymentioning

confidence: 99%

“…Organisms including G. vaginalis, facultative bacteria, and anaerobes recovered from the endometrial cavity of 60% of women with postpartum endometritis were associated with bacterial vaginosis. 80,83,86 Postpartum wound infection after cesarean section may also occur more commonly in women with bacterial vaginosis. 54 Because of these associated complications, accurate diagnosis of bacterial vaginosis is increasingly important in pregnancy and prior to pelvic surgery.…”

Section: Bacterial Vaginosis Pathologymentioning

confidence: 99%

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Evaluation and management of vaginitis

1998

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V aginitis is a common medical problem in women that is associated with substantial discomfort and frequent medical visits. Roughly 5 to 10 million office visits per year are attributed to vaginitis. 1 Research in recent years has increased our understanding of the disease process and its potential sequelae and resulted in improved diagnostic and treatment modalities. 2-6 Nevertheless, adequate diagnosis and treatment of vaginitis in the office setting often is problematic for practitioners. 2,5,7-9 Moreover, the availability of over-the-counter medications for fungal vaginitis has increased the likelihood that women will come to medical attention with partially or inadequately treated infections. 10 We will focus on the common infectious causes of vaginal discharge-yeast infection, bacterial vaginosis, and trichomonas infection, emphasizing new developments in diagnosis, associated complications, and treatment of these infections.The initial evaluation of vaginal discharge requires an understanding of physiologic vaginal discharge and what differentiates it from abnormal, pathologic discharge. Substances from the vulvar, sebaceous, sweat, Bartholin's and Skene's glands, as well as exfoliated cells, cervical mucus, and secretions of the endometrial cavity and fallopian tubes constitute the normal physiologic secretions of the vagina. These secretions pool in the posterior fornix and do not adhere to the vaginal walls. 11 The pH of normal vaginal secretions in women of childbearing age is between 3.8 and 4.5. The presence of sperm, blood, amniotic fluid, or cervical mucus raises the vaginal pH. 11 The amount and fluidity of the discharge can vary over the menstrual cycle. Cervical mucus becomes more fluid around ovulation, and women frequently mistake this change in consistency for an abnormal discharge. Stress increases the rate of vaginal desquamation and thus the amount of discharge, which patients can also mistake for a pathologic discharge. 12 Women generally do not have other symptoms if their discharge is physiologic.In contrast, a pathologic discharge adheres to the vaginal walls and is often accompanied by irritation, pruritus, odor, or urinary symptoms such as dysuria or frequency. 6 The discharge can be thick to watery and frothy, and white to yellow, gray, or green. 11 Causes of an abnormal discharge include infectious causes of vaginitis such as yeast infection, bacterial vaginosis, and trichomonas infection, as well as cervicitis and sexually transmitted diseases such as gonorrhea and chlamydia infection. Noninfectious etiologies include chemical irritants such

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Section: Bacterial Vaginosis Pathologymentioning

confidence: 99%

Section: Bacterial Vaginosis Pathologymentioning

confidence: 99%

Evaluation and management of vaginitis

1998

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“…In one study of 80 such women with BV, oral metronidazole treatment, 250 mg tds for 7 days, of women with BV between 13 and 20 weeks gestation produced a 50% reduction in preterm birth compared with placebo treatment [40]. A second study used combined treatment with metronidazole and erythromycin for women with a high risk of preterm birth [41].…”

Section: Treatment In Pregnancymentioning

confidence: 99%

Sexually transmitted diseases: microbiology and management Proceedings of the Seventh Liverpool Tropical School Bayer Symposium on Microbial Disease held on 6 February 2000

Birley¹,

Duerden

2002

Journal of Medical Microbiology

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“…For women with a previous preterm delivery, there is some evidence that the prenatal administration of 17-alpha-hydroxyprogesterone acetate (24,25) and antibiotics for the treatment of bacterial vaginosis (26)(27)(28)(29)(30)(31) may decrease the risk of a subsequent preterm delivery.…”

Section: Introductionmentioning

confidence: 99%

Interpregnancy Primary Care and Social Support for African-American Women at Risk for Recurrent Very-low-birthweight Delivery: A Pilot Evaluation

Dunlop

Dubin

Raynor

et al. 2007

Matern Child Health J

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Objectives-Very-low-birthweight (VLBW) delivery accounts for the majority of neonatal mortality and the black-white disparity in infant mortality. The risk of recurrent VLBW is highest for African-Americans of lower socioeconomic status. This study explores whether the provision of primary health care and social support following a VLBW delivery improves subsequent child spacing and pregnancy outcomes for low-income, African-American women. Results-Women in the control cohort had, on average, 2.6 (95% CI: 1.1 -5.8) times as many pregnancies within 18 months of the index VLBW delivery and 3.5 (95% CI: 1.0 -11.7) times as many adverse pregnancy outcomes as women in the intervention cohort. Methods-ThisConclusions-This small, pilot study suggests that primary health care and social support for low-income, African-American women following a VLBW delivery may enhance achievement of a subsequent 18-month interpregnancy interval and reduce adverse pregnancy outcomes.

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Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: A placebo-controlled, double-blind study

Cited by 315 publications

References 15 publications

Evaluation and management of vaginitis

Evaluation and management of vaginitis

Sexually transmitted diseases: microbiology and management Proceedings of the Seventh Liverpool Tropical School Bayer Symposium on Microbial Disease held on 6 February 2000

Interpregnancy Primary Care and Social Support for African-American Women at Risk for Recurrent Very-low-birthweight Delivery: A Pilot Evaluation

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