Effect of microneedles shape on skin penetration and transdermal drug administration

Martino, Selene De; Battisti, Mario; Napolitano, Francesco; Palladino, Antonio; Serpico, Luigia; Amendola, Eugenio; Martone, Alfonso; Girolamo, Paolo De; Squillace, Antonino; Dardano, Principia; Stefano, Luca De; Iacono, Stefania Dello

doi:10.1016/j.bioadv.2022.213169

Cited by 27 publications

(8 citation statements)

References 47 publications

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“…Moreover, the base shape of the needles also affects skin penetration. Circular and square shapes have more potential for a successful insertion Figure D–F presents the perforation sites of each MN structure, cone-, pyramid-, and arrow-like, respectively.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Monou,

Andriotis,

Tzetzis

et al. 2024

ACS Appl. Bio Mater.

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In the current study, coated microneedle arrays were fabricated by means of digital light processing (DLP) printing. Three different shapes were designed, printed, and coated with PLGA particles containing two different actives. Rivastigmine (RIV) and N-acetyl-cysteine (NAC) were coformulated via electrohydrodynamic atomization (EHDA), and they were incorporated into the PLGA particles. The two actives are administered as a combined therapy for Alzheimer’s disease. The printed arrays were evaluated regarding their ability to penetrate skin and their mechanical properties. Optical microscopy and scanning electron microscopy (SEM) were employed to further characterize the microneedle structure. Confocal laser microscopy studies were conducted to construct 3D imaging of the coating and to simulate the diffusion of the particles through artificial skin samples. Permeation studies were performed to investigate the transport of the drugs across human skin ex vivo. Subsequently, a series of tape strippings were performed in an attempt to examine the deposition of the APIs on and within the skin. Light microscopy and histological studies revealed no drastic effects on the membrane integrity of the stratum corneum. Finally, the cytocompatibility of the microneedles and their precursors was evaluated by measuring cell viability (MTT assay and live/dead staining) and membrane damages followed by LDH release.

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Section: Resultsmentioning

confidence: 99%

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Monou,

Andriotis,

Tzetzis

et al. 2024

ACS Appl. Bio Mater.

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show abstract

“…It can be defined in different ways (length over the tip diameter of the needle, length over the width of the microneedle, or base over the tip diameter) but it's essential to be kept below 2.0 to prevent needle overlap. [52,53] Miniaturizing hypodermic needles to micron size is a promising approach for minimally invasive, less painful, and low infection risk biofluid extraction. [50] Microneedle platforms aim to combine biomolecule analysis within the device by integrating sensing technologies.…”

Section: Design Principles Of Microneedle Sensorsmentioning

confidence: 99%

Microneedle Sensors for Point‐of‐Care Diagnostics

Hu,

Chatzilakou,

Pan

et al. 2024

Advanced Science

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Point‐of‐care (POC) has the capacity to support low‐cost, accurate and real‐time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique to evolve blood‐based diagnostics owing to their direct and painless access to a rich source of biomarkers from interstitial fluid. This review systematically summarizes the recent innovations in microneedle sensors with a particular focus on their utility in POC diagnostics and personalized medicine. The integration of various sensing techniques, mostly electrochemical and optical sensing, has been established in diverse architectures of “lab‐on‐a‐microneedle” platforms. Microneedle sensors with tailored geometries, mechanical flexibility, and biocompatibility are constructed with a variety of materials and fabrication methods. Microneedles categorized into four types: metals, inorganics, polymers, and hydrogels, have been elaborated with state‐of‐the‐art bioengineering strategies for minimally invasive, continuous, and multiplexed sensing. Microneedle sensors have been employed to detect a wide range of biomarkers from electrolytes, metabolites, polysaccharides, nucleic acids, proteins to drugs. Insightful perspectives are outlined from biofluid, microneedles, biosensors, POC devices, and theragnostic instruments, which depict a bright future of the upcoming personalized and intelligent health management.

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“…Based on this advantage, Selene De Martino and co‐workers fabricated and compared MNs of different shapes, ultimately finding that star‐shaped MNs exhibited the best penetration and drug release capabilities among four different MN base shapes (circular, triangular, square, and star), which contributed to the development of the fabrication of high‐performance MNs. [ 45 ]…”

Section: Preparation Of Responsive Np‐loaded Mnsmentioning

confidence: 99%

Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications

Xie,

Li,

Shi

et al. 2024

Advanced NanoBiomed Research

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Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release of drugs, high bioavailability, painlessness, and good patient compliance. Compared with oral drug delivery, microneedle transdermal drug delivery eliminates the need to pass through the gastrointestinal tract and liver, reducing the metabolic consumption of drugs by first‐pass effect. While compared with intravenous drug delivery, microneedle transdermal drug delivery reduces patient discomfort and does not require professional administration. However, there are few review articles on microneedles loaded with responsive nanoparticles. Herein, the current researches on microneedles loaded with specific responsive nanoparticles such as glucose‐responsive, pH‐responsive, enzyme‐responsive, light‐responsive, magnetic‐responsive, ultrasound‐responsive, and multiresponsive, and the biomedical application of these microneedle array systems are summarized. In addition, the challenges and prospects of microneedle strategies loaded with responsive nanoparticles are briefly discussed, which will facilitate the development of such versatile drug‐delivery strategy.

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Effect of microneedles shape on skin penetration and transdermal drug administration

Cited by 27 publications

References 47 publications

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Microneedle Sensors for Point‐of‐Care Diagnostics

Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications

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