Effect of microplasma treatment on stratum corneum lipid molecule

Abstract

The stratum corneum is a lipid matrix with embedded corneocytes. This layer protects the body against foreign substances and the outer environment. However, the lipid matrix is permeable to selective molecules and this permeability can be improved by several methods. One of these methods includes microplasma irradiation of the skin. Stearic acid is a model fatty acid from the lipid matrix of stratum corneum. In this study, the interaction between microplasma and stearic acid was investigated. Plasma was generated at a low voltage of about 800 V (0-V peak ) using a thin dielectric (∼30 μm) as a barrier. The plasma electrode treated the lipids under an argon atmosphere at a frequency of 25 kHz. The results of the microplasma treatment were investigated by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) and X-ray photoelectron spectroscopy. The concentrations of C, O and N atoms were determined before and after the microplasma treatment. Also, functional groups of C-C/C-H, C-O, C=O, OH-C=O, N-C=O were identified in the carbon spectra. The structure of stearic acid was evaluated by analysis of CH 2 , CH 3 and C=O bands in the ATR-FTIR spectrum.

Transdermal administration of adenosine using microplasma and the examination of the effect of microplasma on stratum corneum using infrared spectroscopy

“…If carbon in C=O molecule is connected only to one R (hydrocarbon chain) it is positioned in 1705-1725 cm −1 characteristic for ketone. 39,40) Area with the highest increase belongs to carboxylic acid. 41) at 1710 cm-1 in our spectrum and the C=O stretching bond at 1744 cm −1 belongs to the ester functional group.…”

Heating and cooling stages using a doubly conjugate thermal and electric asymptotic analysis between a gel and the stratum corneum

“…Also, these previous works are mainly focused on determining the fundamental equations that govern the physics of the problem, for which the obtained solutions are purely numerical. Additional works trying several aspects like the impact of surface properties of the skin on the transdermal drug delivery and cosmetics, the direct visualization of lipids in the stratum corneum and the effect of micro-treatment on stratum corneum lipid molecule, respectively, can be found in other interesting works [18][19][20][21].…”