Effect of microRNA-206 on Cytoskeleton Remodelling by Downregulating Cdc42 in MDA-MB-231 Cells

Abstract

The results suggest that miR-206 may suppress invasion and migration of MDA-MB-231 cells in vitro partly via regulating actin cytoskeleton remodelling such as filopodia formation.

MicroRNA-206 Regulates Cell Movements during Zebrafish Gastrulation by Targeting prickle1a and Regulating c-Jun N-Terminal Kinase 2 Phosphorylation

“…The expression of mir206 is dramatically reduced in an ALS mouse model, and deficiency of mir206 in this ALS mouse model accelerates disease progression (68). mir206 also inhibits cancer cell proliferation, invasion, and metastasis by acting as a tumor suppressor (35,51,54,65,69). mir206 is one of the earliest expressed miRNAs during zebrafish development (8,67), but its role in embryonic development is unclear.…”

Role of microRNA-mediated MMP regulation in the treatment and diagnosis of malignant tumors

“…In breast cancer, two other microRNAs have been shown to indirectly regulate MMP-2 and MMP-9 expression. 48,49 First, miR-206 was found to downregulate MMP-2 and MMP-9 expression at the protein level and inhibit the invasion and migration of MDA-MB-231 cells in vitro. 48 In addition, Wu et al found that miR-340 directly targeted the c-Met gene and consequently inhibited MMP-2 and MMP-9 expression, thereby suppressing tumor cell migration and invasion.…”

“…48,49 First, miR-206 was found to downregulate MMP-2 and MMP-9 expression at the protein level and inhibit the invasion and migration of MDA-MB-231 cells in vitro. 48 In addition, Wu et al found that miR-340 directly targeted the c-Met gene and consequently inhibited MMP-2 and MMP-9 expression, thereby suppressing tumor cell migration and invasion. 49 In addition, miR-9 and miR-196b were shown to regulate gelatinase expression in uveal melanoma 50 and gastric cancer, 51 respectively.…”

MicroRNAs in Invasion and Metastasis in Lung Cancer

“…Liu and his colleagues have found that miR-137 may have a tumor suppressor function by directly targeting Cdc42 to inhibit the proliferation and invasion activities of colorectal cancer cells [49,50]. MiR-206 may suppress invasion and migration of MDA-MB-231 cells in vitro partly via regulating actin cytoskeleton remodelling by downregulating Cdc42 [51]. MiR-29 activates p53 by targeting p85 alpha and Cdc42 [52].…”