A methodology combining diffraction experiments and self-consistent calculations was used to study the mechanical behaviour of groups of grains within two-phase polycrystalline materials. In this work, an Al/SiC p composite and duplex austenitic-ferritic steel are studied. The lattice strain evolution was determined from lattice strain measured in situ during tensile tests using neutron diffraction. The experimental results were used to study slip on crystallographic planes, localisation of stresses in polycrystalline grains and the mechanical effects of damage occurring during plastic deformation. For this purpose, a prediction made using the recently developed new version of the elasto-plastic self-consistent model was compared with the experimental data.