Laser‐based powder bed fusion of metals (PBF‐LB/M) was found to be a promising processing method for the fabrication of components with no limits of complexity by adding layers upon layers of material. However, drawbacks such as productivity and dimension limitations adversely affect the employment of the AM components in envisaged applications. This brings welding and joining techniques into play to integrate AM metal parts into larger assemblies. In this research, electron beam (EB) welding is employed to join the AlSi10Mg specimens, fabricated via two different manufacturing processes, i.e., PBF‐LB/M and casting. The main focus is to study the quasi‐static and fatigue behavior of similar and dissimilar welded joints in different combinations, namely AM‐AM, AM‐Cast, and Cast‐Cast, alongside the microstructure analyses, to investigate the correlation between the microscopic and macroscopic properties. Dissimilar welded joints demonstrate inferior material strength, which can be attributed to the inherent coarse microstructure of the cast material. Although similar welded joints of AM components suffer from a high porosity in the weld zone, they have shown a better fatigue life, which can be contributed to the equiaxed eutectic microstructure in the welded area.This article is protected by copyright. All rights reserved.