Effect of mild hypoxia on delayed differentiation in the monkey (Macaca mulatta)

Nicholson, Anthony N.; Wright, Catherine

doi:10.1016/0014-4886(75)90086-2

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…In another study, Koller et al (1991), observed dysfunctions in the execution of a welllearned task (mental calculation) that demands controlled processing during exposure to an altitude of 6,000 m. The effect was stronger if subjects were not acclimatized (20% vs. 7% error). Nicholson and Wright (1975) observed that under moderate hypoxia (4,572 m, 50 mmHg of PaO 2 ) the execution of a matching task was improved in monkeys. The discrimination task used probably required controlled processing since the relationship between stimuli and responses varied during the task.…”

Section: Retrieval Vs Storage Deficitsmentioning

confidence: 96%

Neuropsychological Functioning Associated with High-Altitude Exposure

et al. 2004

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This article focuses on neuropsychological functioning at moderate, high, and extreme altitude. This article summarizes the available literature on respiratory, circulatory, and brain determinants on adaptation to hypoxia that are hypothesized to be responsible for neuropsychological impairment due to altitude. Effects on sleep are also described. At central level, periventricular focal damages (leuko-araiosis) and cortical atrophy have been observed. Frontal lobe and middle temporal lobe alterations are also presumed. A review is provided regarding the effects on psychomotor performance, perception, learning, memory, language, cognitive flexibility, and metamemory. Increase of reaction time and latency of P300 are observed. Reduced thresholds of tact, smell, pain, and taste, together with somesthetic illusions and visual hallucinations have been reported. Impairment in codification and short-term memory are especially noticeable above 6,000 m. Alterations in accuracy and motor speed are identified at lower altitudes. Deficits in verbal fluency, language production, cognitive fluency, and metamemory are also detected. The moderating effects of personality variables over the above-mentioned processes are discussed. Finally, methodological flaws found in the literature are detailed and some applied proposals are suggested.

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Section: Retrieval Vs Storage Deficitsmentioning

confidence: 96%

Neuropsychological Functioning Associated with High-Altitude Exposure

et al. 2004

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Effect of chronic cyanide intoxication on memory in albino rats

Mathangi

Ambalavanan

2000

Food and Chemical Toxicology

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Effects of Altitude on Mood, Behaviour and Cognitive Functioning

1993

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Alterations in psychological mood, personality, behaviour and cognitive functioning associated with altitude have been recognised for many years. Psychological and behavioural changes resulting from the effects of hypoxia often include increases in euphoria, irritability, hostility and impairment of neuropsychological functions such as vision and memory. There is limited research to indicate that some decrements may persist for up to a year, or longer, after return to lower elevation. However, generalisations of the effects of altitude on mood, behaviour and cognitive function are complicated by differences between studies including the specific tasks or dimensions measured, methods of measurement, degree of altitude, duration of exposure and types of participants. There also appear to be wide individual differences in the response to altitude sojourns. Investigations designed to measure symptoms and mood changes during actual mountain climbs are needed, since most of the systematic research has been conducted in altitude chambers. The extent to which these simulations can be generalised to actual altitude settings remains to be documented.

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Effect of mild hypoxia on delayed differentiation in the monkey (Macaca mulatta)

Cited by 3 publications

References 13 publications

Neuropsychological Functioning Associated with High-Altitude Exposure

Neuropsychological Functioning Associated with High-Altitude Exposure

Effect of chronic cyanide intoxication on memory in albino rats

Effects of Altitude on Mood, Behaviour and Cognitive Functioning

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