Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials

Xu, Jia‐Ying; Qin, Li–Qiang; Wang, Peiyu; Li, Wei; Chang, Chun

doi:10.1016/j.nut.2008.04.004

Cited by 167 publications

(129 citation statements)

References 39 publications

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“…The results are in agreement with those of a previous meta-analysis published by Pripp 8 35 In the present meta-analysis a significant heterogeneity was found between studies carried out on Asian subjects and those involving the European population. Such a difference in the racial response to lactotripeptides was not described in the meta-analysis published by Pripp,8 that differ from our review as it did not include the results of some large recent trials involving the European population and reporting only a small and non significant effect of lactrotripeptides on BP.…”

Section: Discussionsupporting

confidence: 93%

Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials

et al. 2010

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The oral assumption of lactotripeptides Valine-ProlineProline (VPP) and Isoleucine-Proline-Proline (IPP) as nutraceuticals or functional foods is supposed to improve blood pressure (BP) control by angiotensinconverting enzyme-inhibition. However, data derived from clinical trials have reached conflicting conclusions. To perform a meta-analysis of placebo-controlled clinical trials evaluating the anti-hypertensive effect of lactotripeptides assumed as nutraceuticals or functional foods. Trials identified using a defined search strategy in PubMed were included in the meta-analysis, and their pooled effect was estimated with a random effects model, weighting for the inverse of the variance. Heterogeneity, publication bias, subgroup and metaregression analyses were performed. A total of 18 trials have been identified, the clinical data of which have been clearly reported.

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Section: Discussionsupporting

confidence: 93%

Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials

et al. 2010

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“…This is further emphasised by a recent meta-analysis, which shows increasing effect of FM as long as the interventional period lasts. 23 As the mode of action in humans of FM remains widely unknown, a long-term effect cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

“…15,22 In the sole metaanalysis of FM and BP, reduced SBP (4.8 mm Hg) and DBP (2.2 mm Hg) were found after the intake of FM. 23 Exclusively, studies with known concentration of VPP and IPP in the FM were included, and the recent three largest studies of FM with negative results, were not included. 15,20,22 These variable outcomes leave the antihypertensive effect of FM unclear.…”

Section: Introductionmentioning

confidence: 99%

The antihypertensive effect of fermented milk in individuals with prehypertension or borderline hypertension

et al. 2010

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Fermented milk (FM) with putative antihypertensive effect in humans could be an easy applicable lifestyle intervention against hypertension. The mode of action is supposed to be through active milk peptides, shown to possess in vitro ACE-inhibitory effect. Blood pressure (BP) reductions upto 23 mm Hg have been reported in spontaneously hypertensive rats fed FM. Results from human studies of the antihypertensive effect are inconsistent. However, many studies suffer from methodological weaknesses, as insufficient blinding and the use of office BP measurements. We conducted a randomised, double-blind placebo-controlled study of the antihypertensive effect of Lactobacillus helveticus FM in 94 prehypertensive and borderline hypertensive subjects. The participants were randomised into three treatment groups with a daily intake of 150 ml of FM, 300 ml of FM or placebo (chemically acidified milk). The primary outcome was repeated 24-h ambulatory BP measurements. There were no statistically significant differences in the outcome between the groups (systolic BP (SBP), P ¼ 0.9; diastolic BP (DBP), P ¼ 0.2). However, the group receiving 300 ml FM had reduced BP across the 8-week period in several readings, which could be compatible with a minor antihypertensive effect. Heart rate and lipids remained unchanged between groups. Hence, our study does not support earlier studies measuring office BP-measurements, reporting antihypertensive effect of FM. Based on straight performed 24-h ambulatory BP measurements, milk fermented with Lactobacillus helveticus does not posses significant antihypertensive effect.

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“…There was an imbalance in the literature as more RCT were conducted using mainly one type of casein-derived peptides, called lactotripeptides (LTP). We, therefore conducted an updated meta-analysis on the impact of LTP on BP (14) , which included all available and relevant RCT and detailed subgroup and regression analyses, which were somewhat limited in previous meta-analyses in this area (15)(16)(17)(18) . We found a small, but significant reduction in both SBP (−2·95 mmHg (95 % CI −4·17, −1·73; P < 0·001)) and DBP (−1·51 mmHg (95 % CI −2·21, −0·80; P < 0·001)) after 4 weeks of LTP supplementation in pre-and hypertensive populations.…”

Section: Long-term Studies On Blood Pressurementioning

confidence: 99%

Can milk proteins be a useful tool in the management of cardiometabolic health? An updated review of human intervention trials

2016

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The prevalence of cardiometabolic diseases is a significant public health burden worldwide. Emerging evidence supports the inverse association between greater dairy consumption and reduced risk of cardiometabolic diseases. Dairy proteins may have an important role in the favourable impact of dairy on human health such as blood pressure (BP), blood lipid and glucose control. The purpose of this review is to update and critically evaluate the evidence on the impacts of casein and whey protein in relation to metabolic function. Evidence from short-term clinical studies assessing postprandial responses to milk protein ingestion suggests benefits on vascular function independent of BP, as well as improvement in glycaemic homeostasis. Long-term interventions have been less conclusive, with some showing benefits and others indicating a lack of improvement in vascular function. During chronic consumption BP appears to be lowered and both dyslipidaemia and hyperglacaemia seem to be controlled. Limited number of trials investigated the effects of dairy proteins on oxidative stress and inflammation. Although the underlying mechanisms of milk proteins on cardiometabolic homeostasis remains to be elucidated, the most likely mechanism is to improve insulin resistance. The incorporation of meals enriched with dairy protein in the habitual diet may result in the beneficial effects on cardiometabolic health. Nevertheless, future well-designed, controlled studies are needed to investigate the relative effects of both casein and whey protein on BP, vascular function, glucose homeostasis and inflammation.

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Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials

Cited by 167 publications

References 39 publications

Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials

Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials

The antihypertensive effect of fermented milk in individuals with prehypertension or borderline hypertension

Can milk proteins be a useful tool in the management of cardiometabolic health? An updated review of human intervention trials

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