Effect of Mimosa pudica root extract on vaginal estrous and serum hormones for screening of antifertility activity in albino mice

Ganguly, Mausumi; Devi, Nirada; Mahanta, Rita; Borthakur, Mridul Kr.

doi:10.1016/j.contraception.2007.08.008

Cited by 45 publications

(30 citation statements)

References 4 publications

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“…Different concentrations of progesterone (P2), estrogen (E2) and dihydrotestosterone (DHT), either alone or in various combinations, were added to enriched Olg cultures to determine their effects upon total cell numbers, proliferation, and cell death [46]. Female fluctuation of P2 concentration is well known and depends on the phase of estrous cycle [47] as well as pregnancy [48], supporting theoretical contribution of P2 to Olg sexual dimorphism. When hormones were added to Olgs culture, P2 significantly increased the number of Olgs in both sexes (but more so in female cultures), E2 had a minor effect on Olg number and DHT reduced Olg numbers in both sexes.…”

Section: Hormonal Role In Sexual Dimorphism Of Oligodendrocytes: In Vmentioning

confidence: 99%

Sexual dimorphism in the white matter of rodents

Cerghet¹,

Skoff²,

Swamydas³

et al. 2009

Journal of the Neurological Sciences

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Sexual dimorphism of astrocytes and neurons is well documented in many brain and spinal cord structures. Sexual dimorphism of oligodendrocytes (Olgs) and myelin has received less attention. We recently showed that density of Olgs in corpus callosum, fornix, and spinal cord of wild-type male rodents are more densely packed than in females; myelin proteins and myelin gene expression is likewise greater in males than in female rodents. However, glial cell proliferation and cell death were two times greater in female corpus callosum.Endogenous sex hormones, specifically lack of androgens, produce an Olg female phenotype in castrated male mouse. In vitro studies using Olgs culture also showed differences between males and females Olg survival and signaling pathways in response to sexual hormones. Sexual dimorphism of white matter tracts and glia in rodents indicates the necessity for controlling gender in experimental studies of neurodegenerative disorders. Most importantly, our studies suggest that hormones may contribute to sexual dimorphism observed in certain human diseases including multiple sclerosis.

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Section: Hormonal Role In Sexual Dimorphism Of Oligodendrocytes: In Vmentioning

confidence: 99%

Sexual dimorphism in the white matter of rodents

Cerghet¹,

Skoff²,

Swamydas³

et al. 2009

Journal of the Neurological Sciences

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“…Various pharmacological attributes like anti‐inflammatory (Vikram and others ), antinociceptive (Karthikeyan and Deepa ; Vikram and others ), hypolipidemic (Rajendran and Krishnakumar ; Sowmya and Ananthi ), hepatoprotective (Rajendran and others ), and diuretic (Sangma and others ) activities are ascribed to different parts of the plant. M. pudica is also admired for its antidiabetic (Sutar and others ), antimalarial (Tran and others ), anticonvulsant (Bum and others ), antidepressant (Molina and others ), antifertility (Valsala and Karpagagaanapathy ; Ganguly and others ), and antidiarrheal potentials (Balakrishnan and others 2006a). Antiparasitic (Marimuthu and others ), antimicrobial (Ambikapathy and others ; Mohan and others ; Tamilarasi and Anathi ), antioxidant (Rekha and others ; Arokiyaraj and others ), antivenomic (Ambikabothy and others ; Sia and others ), and wound‐healing activities (Paul and others ) are credited to different parts of M. pudica .…”

Section: Introductionmentioning

confidence: 99%

Mimosa pudica L., a High‐Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals

Muhammad

Hussain

Jantan³

et al. 2015

Comp Rev Food Sci Food Safe

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Mimosa pudica Linn. (Family: Mimosaceae) is used as an ornamental plant due to its thigmonastic and nyctinastic movements. M. pudica is also used to avoid or cure several disorders like cancer, diabetes, hepatitis, obesity, and urinary infections. M. pudica is famous for its anticancer alkaloid, mimosine, along with several valuable secondary metabolites like tannins, steroids, flavonoids, triterpenes, and glycosylflavones. A wide array of pharmacological properties like antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, antinociceptive, anticonvulsant, antidepressant, antidiarrheal, hypolipidemic activities, diuretic, antiparasitic, antimalarial, and hypoglycemic have been attributed to different parts of M. pudica. Glucuronoxylan polysaccharide extruded from seeds of M. pudica is used for drug release formulations due to its high swelling index. This review covers a thorough examination of functional bioactives as well as pharmacological and phytomedicinal attributes of the plant with the purpose of exploring its pharmaceutical and nutraceutical potentials.

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“…P2 concentration in mouse sera depends upon the phase of estrous cycle. In one mouse study (Ganguly et al, 2007), P2 ranged from 30–68 nM depending upon the cycle stage and in another study (Anupriwan et al, 2008), P2 was greater than 100 nM during pseudo-pregnancy but decreased to undetectable levels after ovulation. In rat brain, P2 levels appear to be 4× greater than in serum, presumably due to local steroidogenic synthesis (Schumacher et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Sexual dimorphism of oligodendrocytes is mediated by differential regulation of signaling pathways

Swamydas

Bessert

Skoff

2008

J of Neuroscience Research

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Sexual dimorphism of white matter has not been considered important, the assumption being that sex hormones are not essential for glial development. We recently showed exogenous hormones in vivo differentially regulate in male and female rodents the lifespan of oligodendrocytes (Olgs) and amount of myelin (Cerghet et al., 2006). To determine which hormones regulate male and female Olg development, we prepared enriched Olg cultures grown in serum free medium with estrogen (E2), progesterone (P2), and dihydrotestosterone (DHT) or their combinations. P2 significantly increased the number of Olgs in both sexes but more so in females; E2 had minor effects on Olg numbers; and DHT reduced Olgs numbers in both sexes but more so in females. Combinations of hormones affected Olg numbers differently than single hormones. The change in Olg numbers was not due to changes in proliferation but rather survival. P2 increased pAKT many-fold but MAPK levels were unchanged, indicating activation of the Akt pathway by P2 is sufficient to regulate Olg differentiation. DHT reduced pAkt in both sexes but differentially increased pMAPK in males and decreased it in females. Stressing Olgs reveals that both sexes are protected by P2 but females are slightly better protected than males. Females always showed greater differences than males regarding changes in Olg numbers and in signaling molecules. Given the greater fluctuation of neurosteroids in women than in men and the higher incidence of multiple sclerosis (MS) in women, these sexually dimorphic differences may contribute to differences in male and female MS lesions.

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Effect of Mimosa pudica root extract on vaginal estrous and serum hormones for screening of antifertility activity in albino mice

Cited by 45 publications

References 4 publications

Sexual dimorphism in the white matter of rodents

Sexual dimorphism in the white matter of rodents

Mimosa pudica L., a High‐Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals

Sexual dimorphism of oligodendrocytes is mediated by differential regulation of signaling pathways

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