Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model

Kuiken, Nicoline S. S.; Rings, Edmond H. H. M.; Havinga, Rick; Groen, Albert K.; Tissing, Wim J. E.

doi:10.1007/s00520-015-2911-6

Cited by 16 publications

(15 citation statements)

References 30 publications

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“…This model has contributed greatly to the understanding of various apects of CIM (203). While (140), milk bioactives with/without other compounds (23,24,37,85,195), oral insulin (109), dexamethasone (115), and feeding strategies such as minimal enteral feeding (108).…”

Section: Models Of Cim In Rodents Strengths and Limitationsmentioning

confidence: 99%

Animal models of chemotherapy-induced mucositis: translational relevance and challenges

Sangild

Shen

Pontoppidan

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs, and several animal models of CIM have been developed, mainly in rodents and piglets, to help understand the progression of CIM and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e.g., GIT) insights, standardized, clinically relevant treatment regimens, and discovery of new biomarkers. Still, surprisingly few results from animal models have been translated into clinical CIM management and treatments. The results obtained from specific animal models can be difficult to translate to the diverse range of CIM manifestations in patients, which vary according to the antineoplastic drugs, dose, underlying (cancer) disease, and patient characteristics (e.g., age, genetics, and body constitution). Another factor that hinders the direct use of results from animals is inadequate collaboration between basic science and clinical science in relation to CIM. Here, we briefly describe CIM pathophysiology, particularly the basic knowledge that has been obtained from CIM animal models. These model studies have indicated potential new preventive and ameliorating interventions, including supplementation with natural bioactive diets (e.g., milk fractions, colostrum, and plant extracts), nutrients (e.g., polyunsaturated fatty acids, short-chain fatty acids, and glutamine), and growth factor peptides (e.g., transforming growth factor and glucagon-like peptide-2), as well as manipulations of the gut microbiota (e.g., prebiotics, probiotics, and antibiotics). Rodent CIM models allow well-controlled, in-depth studies of animals with or without tumors while pig models more easily make clinically relevant treatment regimens possible. In synergy, animal models of CIM provide the basic physiological understanding and the new ideas for treatment that are required to make competent decisions in clinical practice.

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Section: Models Of Cim In Rodents Strengths and Limitationsmentioning

confidence: 99%

Animal models of chemotherapy-induced mucositis: translational relevance and challenges

Sangild

Shen

Pontoppidan

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…4,5 Minimization of eating disruptions also is an important determinant of quality of life following transplant, at least in adolescents, 18 and maintenance of enteral intake may reduce mucositis severity. 6 Finally, improvement in complete CINV control may result in cost savings through reduction in PN use.…”

Section: Discussionmentioning

confidence: 99%

“…Through its effect on enteral intake, CINV in the HSCT population may also increase mucositis severity, increase the risk of hepatobiliary toxicity and increase gut acute GvHD (aGvHD) severity. [3][4][5][6] We have previously shown that complete chemotherapy-induced vomiting (CIV) control in pediatric HSCT patients is seldom achieved. 7 Nausea control in pediatric HSCT patients has never been evaluated using a validated tool.…”

Section: Introductionmentioning

confidence: 99%

The burden of chemotherapy-induced nausea and vomiting in children receiving hematopoietic stem cell transplantation conditioning: a prospective study

Flank

Sparavalo

Vol

et al. 2017

Bone Marrow Transplant

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This prospective study describes chemotherapy-induced nausea and vomiting (CINV) in children (4-18 years) receiving their first hematopoietic stem cell transplant. Emetic episodes, nausea severity (assessed using a validated, self-report nausea severity assessment tool) and antiemetic administration were documented from the start of conditioning until 24 h after the last conditioning agent was administered (acute) and for a further 7 days (delayed). Relationships between CINV control and parenteral nutrition (PN) use and acute gut GvHD (aGvHD) were explored. Fifty-nine children (4.6-17.4 years) were evaluable. Complete chemotherapy-induced vomiting (CIV; acute: 24%; delayed 22%) and chemotherapy-induced nausea (CIN; acute 7%; delayed 12%) control rates were low. Few children experienced complete CINV control (no vomiting/retching and no nausea) during the acute (5%) or delayed phases (12%). Children experiencing complete acute or delayed CIN control or complete delayed CIV control were more likely to have received: a lower proportion of their total energy requirement as PN at the end of the delayed phase (P<0.036) and PN for a shorter time (P<0.044). Low patient numbers did not permit evaluation of the association between gut aGvHD and CINV control. Effective and safe interventions aimed at improving CINV control in children are required.

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“…Universidade Federal do Vale do São Francisco. (KUIKEN et al, 2016;KIM et al, 2015;REBER et al, 2015).…”

Section: Adriana Gradelaunclassified

RESISTÊNCIA MECÂNICA E COMPOSIÇÃO MINERAL DAS CONCHAS DE MEXILHÕES (Pachoides pectinatus)

Nunes¹,

Silva²,

Marinho³

et al. 2019

O Estudo De Anatomia Simples E Dinâmico

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Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model

Cited by 16 publications

References 30 publications

Animal models of chemotherapy-induced mucositis: translational relevance and challenges

Animal models of chemotherapy-induced mucositis: translational relevance and challenges

The burden of chemotherapy-induced nausea and vomiting in children receiving hematopoietic stem cell transplantation conditioning: a prospective study

RESISTÊNCIA MECÂNICA E COMPOSIÇÃO MINERAL DAS CONCHAS DE MEXILHÕES (Pachoides pectinatus)

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