Effect of Minimally Invasive Spine Stabilization in Metastatic Spinal Tumors

Nakanishi, Kazuo; Uchino, Kenji; Watanabe, Seiya; Misaki, Kosuke; Iba, Hideaki

doi:10.3390/medicina58030358

Cited by 6 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Preemptive prophylactic surgeries and palliative interventions such as posterior fixation and decompression ( 41 ), separation surgery ( 42 ) and balloon kyphoplasty (BKP), including percutaneous vertebroplasty (PVP) ( 43 ), have been reported. Minimally invasive spine stabilization surgery (MISt) using percutaneous pedicle screw (PPS) fixation, which has been conducted commonly in Japan since 2005, applies to cancer patients in poor general condition ( 27 ). MISt is a minimally invasive fixation method that involves temporal stabilization of the spine using a PPS, which alleviates pain, promotes early ADL improvement, and prevents pathological fractures.…”

Section: Advances In Treatments For Spinal Metastasismentioning

confidence: 99%

“…Approaches that render the management of spinal metastases less invasive, including radiotherapy, BKP, and MISt, are collectively referred to as MIST ( 17 ). MIST can provide an improvement in prognosis for patients ineligible for conventional invasive surgery ( 17 , 27 ). MIST have expanded the indications for surgery and become essential for patients with cancer.…”

Section: Advances In Treatments For Spinal Metastasismentioning

confidence: 99%

“…Nakanisi et al. ( 27 ) found that no patients needed further surgery with temporary fixation using MISt and concluded that it was suitable until unstable lesional vertebral bodies were remodeled and stabilized.…”

Section: Advances In Treatments For Spinal Metastasismentioning

confidence: 99%

“…Thus, a primary objective in treating spinal metastases is to avoid pain, mechanical instability, and neurological deficits. As the SRE occurrence rate in patients with spinal metastasis was reported to be approximately 20% (23, 24), SRE prevention is gaining attention (25)(26)(27)(28). Among SREs, symptomatic metastatic epidural spinal cord compression (MESCC) may result in nearly 20% of patients with spinal metastasis (23, 24).…”

Section: Multidisciplinary Approaches For Spinal Metastasismentioning

confidence: 99%

“…Atanasiu et al (106) found that bone transplantation is necessary for patients with a life expectancy of 2 years or more. Nakanisi et al (27) found that no patients needed further surgery with temporary fixation using MISt and concluded that it was suitable until unstable lesional vertebral bodies were remodeled and stabilized.…”

Section: Comparison Between Conventional Procedures and Mistmentioning

confidence: 99%

See 4 more Smart Citations

A new era in the management of spinal metastasis

Morimoto,

Toda,

Hakozaki

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Despite the recent advances in cancer treatment, the incidence of patients with spinal metastases continues to grow along with the total number of cancer patients. Spinal metastases can significantly impair activities of daily living (ADL) and quality of life (QOL), compared with other types of bone metastases, as they are characterized with severe pain and paralysis caused by skeletal-related events. Reduced ADL can also lead to treatment limitations as certain anticancer agents and radiation therapy are not compatible treatments; thus, leading to a shorter life expectancy. Consequently, maintaining ADLs in patients with spinal metastases is paramount, and spine surgeons have an integral role to play in this regard. However, neurosurgeon, orthopedic and spinal surgeons in Japan do not have a proactive treatment approach to spinal metastases, which may prevent them from providing appropriate treatment when needed (clinical inertia). To overcome such endemic inertia, it is essential for 1) spine surgeons to understand and be more actively involved with patients with musculoskeletal disorders (cancer locomo) and cancer patients; 2) the adoption of a multidisciplinary approach (coordination and meetings not only with the attending oncologist but also with spine surgeons, radiologists, rehabilitation specialists, and other professionals) to preemptive treatment such as medication, radiotherapy, and surgical treatment; and 3) the integration of the latest findings associated with minimally invasive spinal treatments that have expanded the indications for treatment of spinal metastases and improved treatment outcomes. This heralds a new era in the management of spinal metastases.

show abstract

Section: Advances In Treatments For Spinal Metastasismentioning

confidence: 99%

Section: Advances In Treatments For Spinal Metastasismentioning

confidence: 99%

Section: Advances In Treatments For Spinal Metastasismentioning

confidence: 99%

Section: Multidisciplinary Approaches For Spinal Metastasismentioning

confidence: 99%

Section: Comparison Between Conventional Procedures and Mistmentioning

confidence: 99%

See 3 more Smart Citations

A new era in the management of spinal metastasis

Morimoto,

Toda,

Hakozaki

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

The role of minimally invasive surgery within a multidisciplinary approach for patients with metastatic spine disease over a decade: A systematic review

Schupper,

Patel,

Steinberger

et al. 2023

Neuro-Oncology

View full text Add to dashboard Cite

Background Metastatic spine disease (MSD) occurs commonly in cancer patients causing pain, spinal instability, devastating neurological compromise, and decreased quality of life. Oncological patients are often medically complex and frail, precluding them form invasive procedures. To address this issue, minimally invasive spinal surgery (MISS) techniques are desirable. The aim of this study is to review published peer-reviewed literature and ongoing clinical trials to provide current state of the art. Methods A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, assessing MISS in MSD patients for the period 2013–2023. Innovations under development were assessed by querying and reviewing data from currently enrolling U.S. registered clinical trials. Results From 3,696 articles, 50 studies on 3,196 patients focused on spinal oncology MISS. The most commonly reported techniques were vertebral augmentation (VA), percutaneous spinal instrumentation, and radiofrequency ablation (RFA). Surgical instrumentation/stabilization techniques were reported in 10/50 articles for a total of 410 patients. The majority of studies focused on pain as a primary outcome measure, with 28/50 studies reporting a significant improvement in pain following intervention. In the United States, 13 therapeutic trials are currently recruiting MSD patients. Their main focus includes radiosurgery, VA and/or RFA, and laser interstitial thermal therapy. Conclusions Due to their medical complexity and increased fragility, MSD patients may benefit from minimally invasive approaches. These strategies are effective at mitigating pain and preventing neurological deterioration, while providing other advantages including ease to start/resume systemic/radiotherapy treatment(s).

show abstract

Evaluation of Epidemiological and Pathological Features of Symptomatic Spinal Metastases in Romania—What Could We Learn from a Retrospective Study?

Șelaru,

Eva,

Sava

et al. 2024

Preprint

View full text Add to dashboard Cite

Background and Objectives: Metastases are the most common tumors of the spine. As an important increase in the annual incidence of spinal metastases (SM) has been observed in the last decade, the aim of this study was to describe the epidemiology and histopathological types of SM surgically treated in the neurosurgery clinics of a regional hospital in North-Eastern Romania over a period of 5 years, in order to define a certain tumor profile that would benefit from an early screening. Materials and Methods: We retrospectively evaluated 115 adult patients, searching for demographic data (gender and age of the patients), primary tumor characteristics (location and histological type), topography and histopathological type of the spinal metastasis, and the time interval between the diagnosis of the primary tumor and the surgery for the spinal metastasis. Results: The patients were elderly (average age = 58.96 years), with a male predominance (67.82%). Main location of SM was in thoracic region (44.34%), with multiple vertebral metastases in 30.43% patients. Only 33.04% of the patients had a known cancer at the time of admission. Primary tumor was located mainly in lung (47.82%), gastrointestinal tract (15.65%), breast (11.30%), prostate (10.43%) and kidney (9.56%). SM from lung cancer mostly expressed squamous cell carcinoma (19.13%), and those from the digestive system mostly exhibited a moderately/poor colorectal adenocarcinoma (8.69%). Conclusions: Our data suggest the need for close surveillance of patients diagnosed with lung cancer and colorectal cancer because these malignancies most frequently develop spinal metastases. Smoking prevention actions and screening programs for the detection and removal of precancerous colorectal lesions must be developed and expanded.

show abstract

Effect of Minimally Invasive Spine Stabilization in Metastatic Spinal Tumors

Cited by 6 publications

References 23 publications

A new era in the management of spinal metastasis

A new era in the management of spinal metastasis

The role of minimally invasive surgery within a multidisciplinary approach for patients with metastatic spine disease over a decade: A systematic review

Evaluation of Epidemiological and Pathological Features of Symptomatic Spinal Metastases in Romania—What Could We Learn from a Retrospective Study?

Contact Info

Product

Resources

About