Effect of mirtazapine on pruritus in patients on hemodialysis: a cross-over pilot study

Gholyaf, Mahmoud; Sheikh, Vida; Yasrebifar, Fatemeh; Mohammadi, Younes; Mirjalili, Mahtabalsadat; Mehrpooya, Maryam

doi:10.1007/s11255-020-02473-3

Cited by 23 publications

(11 citation statements)

References 41 publications

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“…Both paroxetine and mirtazapine can be effective options in pruritus due to malignancies [94,95]. Furthermore, the cross-over randomized clinical trial by Gholyaf et al showed that mirtazapine could be effective for UP patients who are on maintenance hemodialysis [96].…”

Section: Uremic Pruritusmentioning

confidence: 99%

Use of Sertraline in Hemodialysis Patients

et al. 2021

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Depression and anxiety are the most common psychiatric disorders in end-stage renal disease (ESRD) patients treated with hemodialysis (HD) and may correlate with lower quality of life and increased mortality. Depression treatment in HD patients is still a challenge both for nephrologists and psychiatrists. The possible treatment of depressive disorders can be pharmacological and non-pharmacological. In our article, we focus on the use of sertraline, the medication which seems to be relatively safe and efficient in the abovementioned population, taking under consideration several limitations regarding the use of other selective serotonin reuptake inhibitors (SSRIs). In our paper, we discuss different aspects of sertraline use, taking into consideration possible benefits and side effects of drug administration like impact on QTc (corrected QT interval) prolongation, intradialytic hypotension (IDH), chronic kidney disease-associated pruritus (CKD-aP), bleeding, sexual functions, inflammation, or fracture risk. Before administering the medication, one should consider benefits and possible side effects, which are particularly significant in the treatment of ESRD patients; this could help to optimize clinical outcomes. Sertraline seems to be safe in the HD population when provided in proper doses. However, we still need more studies in this field since the ones performed so far were usually based on small samples and lacked placebo control.

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Section: Uremic Pruritusmentioning

confidence: 99%

Use of Sertraline in Hemodialysis Patients

et al. 2021

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“…Previous case reports showed that mirtazapine at a daily dose of 15 mg or more exerted beneficial effects on the pruritus associated with atopic skin disease and other conditions 5,11 and also on pruritus in patients receiving hemodialysis. 6,7 This case was treated with mirtazapine at a dose of 7.5 mg per day, which attenuated pruritus after 4 days. Therefore, 7.5 mg of mirtazapine daily may be a sufficient dose to exert antipruritic effects in patients with uremic pruritus.…”

Section: Discussionmentioning

confidence: 99%

“…1,5 In this study, mirtazapine alleviated uremic pruritus in a patient receiving hemodialysis, which is consistent with previous findings. 6,7 Therefore, mirtazapine has potential as a novel treatment for pruritus in hemodialysis patients.…”

Section: Discussionmentioning

confidence: 99%

“…4 The antidepressant mirtazapine was reported to be an effective treatment for pruritus in patients with malignant cholestasis, lymphoma, and uremia. 5 Recent studies demonstrated that mirtazapine effectively attenuated pruritus in patients receiving hemodialysis; 6,7 however, it currently remains unclear whether mirtazapine exerts differential effects on depression and pruritus in patients receiving hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

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Differential onset time of mirtazapine on pruritus and depression in a patient receiving hemodialysis

Miyahara

Haruta-Tsukamoto

Funahashi

et al. 2021

SAGE Open Medical Case Reports

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A 63-year-old male receiving hemodialysis for renal insufficiency developed severe and widespread pruritus, which was unresponsive to antihistamines and severe depression with insomnia, agitation, and anxiety. The oral administration of 7.5 mg mirtazapine daily alleviated his severe pruritus after 4 days and severe depression after 14 days. Mirtazapine has potential as a therapeutic option for patients receiving hemodialysis with depressive disorder and severe pruritus unresponsive to antihistamines.

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“…MTZ may find utility in SIB cases, but to date, no efficacy studies in NHPs have been published. Other indicated uses of MTZ are its effects beneficial for people also suffering from insomnia, pain, vomiting, nausea, loss of appetite, 37 and for pruritus 38 . Future studies are indicated for other uses of transdermal MTZ based on the effects seen in people and other species of domestic and laboratory animals.…”

Section: Discussionmentioning

confidence: 99%

Effects of transdermal mirtazapine on hyporexic rhesus and cynomolgus macaques (Macaca mulatta and Macaca fascicularis)

Mendoza¹,

Stockinger²,

Cukrov³

et al. 2021

J of Medical Primatology

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Background Hyporexia and weight loss are important indicators of physical and psychological well‐being in macaque colonies. An FDA‐approved transdermal formulated Mirtazapine (MTZ) shows effectiveness in managing feline hyporexia. This study sought to determine its effectiveness as an appetite stimulant in macaques. Methods Fourteen macaques with idiopathic hyporexia, intractable to conventional management were treated with transdermal MTZ (0.5 mg/kg) topically administered to aural pinnae once daily for 14 days. Qualitative food consumption was monitored daily for 6 months. Body weights were collected prior to treatment, every 2 weeks for the first 6 weeks, 10 weeks, and 6 months post‐treatment. Results Transdermal MTZ significantly reduced the frequency of hyporexia during treatment and monthly for 6 months. No significant increase in weight noted until approximately 6 months post‐treatment. Conclusions Results from this study indicate that a short course of transdermal MTZ is an effective way to increase food consumption in macaques chronically.

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Effect of mirtazapine on pruritus in patients on hemodialysis: a cross-over pilot study

Cited by 23 publications

References 41 publications

Use of Sertraline in Hemodialysis Patients

Use of Sertraline in Hemodialysis Patients

Differential onset time of mirtazapine on pruritus and depression in a patient receiving hemodialysis

Effects of transdermal mirtazapine on hyporexic rhesus and cynomolgus macaques (Macaca mulatta and Macaca fascicularis)

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