Effect of Mixture of Atractylodes macrocephala and Amomum villosum Extracts on Body Weight and Lipid Metabolism in High Fat Diet-Induced Obesity Model

Kim, Ha Rim; Kwon, Yong Kwan; Choi, Bong Keun; Jung, Hyun Jong; Baek, Dong Gi

doi:10.15188/kjopp.2020.04.34.2.75

Cited by 6 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mixture at a ratio of 3:1 significantly inhibited OP9 adipocyte differentiation [24] and weight gain induced by high-fat diet [25,26]. In particular, Kim et al [26] reported that the anti-obesity effects was confirmed in the DIO1 model administrated with AME:AVE (3:1) while inducing obesity. Based on these studies, the present study confirmed the anti-obesity effects and the underlying mechanisms of adipogenesis and lipogenesis in 3T3-L1 cells.…”

Section: Discussionmentioning

confidence: 93%

“…Recently, the treatment with Atractylodes macrocephala and Amomum villosum extract (AME:AVE (3:1)) resulted in excellent anti-obesity effect [25]. The mixture at a ratio of 3:1 significantly inhibited OP9 adipocyte differentiation [24] and weight gain induced by high-fat diet [25,26]. In particular, Kim et al [26] reported that the anti-obesity effects was confirmed in the DIO1 model administrated with AME:AVE (3:1) while inducing obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been reported that a mixture of Atractylodes macrocephala and Amomum villosum extracts significantly inhibited OP9 adipocyte differentiation [24] and weight gain induced by high-fat diet [25,26]. Especially, Kim et al [26] reported that the anti-obesity effects mediated by decreased expression of adipogenesis-and lipogenesis-related genes expressions was confirmed in the diet-induced obesity 1 (DIO1) model induced with AME:AVE (3:1). Based on these studies, we hypothesized that AME:AVE (3:1) might also have anti-obesity effects in 3T3-L1 cells and obesity-induced DIO2 models.…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacological studies have shown that Amomi Fructus has strong anti-ulcer, anti-diarrhea, anti-inflammatory, and antimicrobial activities [23]. Recently, it has been reported that a mixture of Atractylodes macrocephala and Amomum villosum extracts significantly inhibited OP9 adipocyte differentiation [24] and weight gain induced by high-fat diet [25,26]. Especially, Kim et al [26] reported that the anti-obesity effects mediated by decreased expression of adipogenesis-and lipogenesis-related genes expressions was confirmed in the diet-induced obesity 1 (DIO1) model induced with AME:AVE (3:1).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, in this study, the anti-obesity effects and the underlying mechanisms of adipogenesis and lipogenesis in 3T3-L1 cells and HFD-induced obesity in mice model were investigated using a 3:1 mixture of Atractylodes macrocephala and Amomum villosum extracts reported by Kim et al [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Anti-Obesity Effects of a Mixture of Atractylodes macrocephala and Amomum villosum Extracts on 3T3-L1 Adipocytes and High-Fat Diet-Induced Obesity in Mice

Kim¹,

Lee²,

Min³

et al. 2022

Molecules

View full text Add to dashboard Cite

Since the potential of (3:1) mixtures of Atractylodes macrocephala and Amomum villosum extracts has been proposed in the management of obesity, the purpose of present study was to investigate the effects of AME:AVE (3:1) mixture on weight loss, obesity-related biochemical parameters, adipogenesis and lipogenesis related proteins in 3T3-L1 cells and HFD-induced obesity in a mouse model. Treatment with AME:AVE (3:1) mixture inhibited lipid accumulation. Furthermore, the treatment with 75 and 150 mg/kg of AME:AVE (3:1) significantly decreased the body weight gain, white adipose tissue (WAT) weight, and plasma glucose level in HFD-induced obese mice. Moreover, treatment with 75 and 150 mg/kg AME:AVE (3:1) also significantly lowered the size of adipocytes in adipose tissue and reduced the lipid accumulation in liver. AME:AVE (3:1) treatment significantly decreased the expression of proteins related to adipogenesis and lipogenesis in 3T3-L1 adipocytes and WAT of HFD-induced obese mice. These results suggest that the AME:AVE herbal mixture (3:1) has anti-obesity effects, which may be elicited by regulating the expression of adipogenesis and lipogenesis-related proteins in adipocytes and WAT in HFD-induced obesity in mice.

show abstract