Effect of mobile phone signal radiation on epigenetic modulation in the hippocampus of Wistar rat

Ranjeet, Kumar; Deshmukh, Pravin Suryakantrao; Sharma, Sonal; Banerjee, Basu Dev

doi:10.1016/j.envres.2020.110297

Cited by 19 publications

(13 citation statements)

References 68 publications

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“…There is limited research on the potential for RF-radiation exposure to alter DNA methylation patterns. To date, it has been suggested that RF radiation can alter DNA methylation in the estrogen receptor of colon cells of rats [ 62 ]; a single study reported modified DNA methylation patterns in the brain of rats, more precisely in the hippocampus [ 63 ] as a result of RF exposure.…”

Section: Discussionmentioning

confidence: 99%

Pilot Study of the Long-Term Effects of Radiofrequency Electromagnetic Radiation Exposure on the Mouse Brain

Spandole-Dinu¹,

Catrina²,

Voinea

et al. 2023

IJERPH

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The increasing radiofrequency (RF) electromagnetic radiation pollution resulting from the development and use of technologies utilizing RF has sparked debate about the possible biological effects of said radiation. Of particular concern is the potential impact on the brain, due to the close proximity of communication devices to the head. The main aim of this study was to examine the effects of long-term exposure to RF on the brains of mice in a real-life scenario simulation compared to a laboratory setting. The animals were exposed continuously for 16 weeks to RF using a household Wi-Fi router and a laboratory device with a frequency of 2.45 GHz, and were compared to a sham-exposed group. Before and after exposure, the mice underwent behavioral tests (open-field test and Y-maze); at the end of the exposure period, the brain was harvested for histopathological analysis and assessment of DNA methylation levels. Long-term exposure of mice to 2.45 GHz RF radiation increased their locomotor activity, yet did not cause significant structural or morphological changes in their brains. Global DNA methylation was lower in exposed mice compared to sham mice. Further research is needed to understand the mechanisms behind these effects and to understand the potential effects of RF radiation on brain function.

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Section: Discussionmentioning

confidence: 99%

Pilot Study of the Long-Term Effects of Radiofrequency Electromagnetic Radiation Exposure on the Mouse Brain

Spandole-Dinu¹,

Catrina²,

Voinea

et al. 2023

IJERPH

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“…The results showed that traveling wave radiation was associated with genotoxicity and behavioral changes, which can be attributed to the microwave nonthermal effect. MWR changed the contents of DNA methylase, DNA methyltransferase, and chromatin histone methyltransferase in the hippocampus of wister rats . Millimeter wave exposure of 20 mW/cm 2 resulted in increased temperature and strong alterations in keratinocyte gene expression.…”

Section: Introductionmentioning

confidence: 96%

“…However, the nonthermal effect of microwaves on organisms remains controversial and questionable. There are abundant experimental reports on the effect of organisms under weak MWR, including the effects of microwaves on animal behavior, cell behavior, and molecule behavior, which have both thermal and nonthermal effects of microwaves. − Under the MWR of 60 W of 2.4 GHz for 9 days, the waking time of mice increased by 16.2%, the time of rapid eye movement decreased by 9.2%, and the time of nonrapid eye movement decreased by 8.2% . This suggested that excessive wireless electromagnetic exposure is an important potential factor affecting sleep structure.…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics Research of Spatial Orientation and Kinetic Energy of Active Site Collision of Carnosine under Weak Microwave Irradiation

et al. 2022

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The molecular mechanism of the microwave nonthermal effect is still not clear. This work investigated the spatial orientation and kinetic energy of active site collision of carnosine, a natural bioactive dipeptide, under the weak microwave irradiation using the molecular dynamics simulation. Our results showed the influences of the temperature, microwave intensity, microwave frequency, and microwave polarization mode (linear polarization and circular polarization) on the spatial orientation and kinetic energy of active site collision of carnosine. First, under the constant intensity and frequency of linear polarization microwave irradiation, the increment of the collision probability between the 6N atom of carnosine and the 28H atom of the other carnosine at effective space angle decreases from 85.0% to 3.5% with increasing temperature. Second, with the increase of microwave intensity, the change of spatial orientation and kinetic energy becomes more and more significant. However, the change of circular polarization microwaves on the spatial orientation and kinetic energy of collision is weaker than that of linear polarization. Third, under the constant intensity of linear polarization microwave irradiation, the collision probability between the 6N atom and the 28H atom at effective space angle decreases from 70.2% to 14.7% with increasing frequency. Finally, under the microwave polarization, the spatial orientation and kinetic energy of molecular collision are changed, which is summarized as the microwave postpolarization effect (MWPPE). The dependence of MWPPE on temperature, microwave intensity, microwave frequency, and polarization mode is very complicated. In the end, this effect can provide a new insight into the molecular mechanism of the microwave nonthermal effect.

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“…Contradictory results have been reported by different in vivo and in vitro experiments in various types of cells using a variety of proteomic and transcriptomic techniques. In the hippocampus of Wistar rats, it has been indicated that RFR may lead to profound epigenetic modifications, which in turn may cause alterations in gene expression [3]. Proteomics techniques have proved that human endothelial cell line EA.hy926 [4] and lens epithelial cells [5] show alterations in protein expression following exposure to RF-EMF.…”

Section: Introductionmentioning

confidence: 99%

Mobile phone radiation might alter gene expression in the oral squamous epithelial cells

Khalil

Al-Qaoud

Alemam

et al. 2022

Egypt J Med Hum Genet

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Background Accumulating evidence has shown that radiofrequency radiation (RFR) emitted by mobile phones is a potential factor for DNA damage. Whether RFR affects the gene expression of human genes still requires further research. This may help in understanding the mechanisms of action of this radiation. On the assumption that expression of BAMBI and Survivin in the oral squamous epithelial cells might be modified in response to RF electromagnetic field (RF-EMF) exposure, the current study was conducted on a group of young university student volunteers. Results Statistical analysis of the RT-PCR data indicated that no significant association (P value ˃ 0.05) exists between the expression of either gene, and neither the length of history nor the frequency of the phone use. Conclusions Although no clear RF-EMF signature on gene expression could be detected in this in this preliminary study, it is one of the few studies indicating that molecular-level changes might take place in humans in response to chronic mobile phone EMR exposure. Further investigations in this field are warranted.

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Effect of mobile phone signal radiation on epigenetic modulation in the hippocampus of Wistar rat

Cited by 19 publications

References 68 publications

Pilot Study of the Long-Term Effects of Radiofrequency Electromagnetic Radiation Exposure on the Mouse Brain

Pilot Study of the Long-Term Effects of Radiofrequency Electromagnetic Radiation Exposure on the Mouse Brain

Molecular Dynamics Research of Spatial Orientation and Kinetic Energy of Active Site Collision of Carnosine under Weak Microwave Irradiation

Mobile phone radiation might alter gene expression in the oral squamous epithelial cells

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