Effect of Moderate Daily Exercise on Acute Glomerulonephritis

Stefaniak, John; La, Hank; Garancis, John C.; Sadowski, Marcin; Shapiro, Dvorah Sara; Fitts, Robert H.; Courtright, James B.; Cornacoff, Joel B.

doi:10.1159/000182238

Cited by 8 publications

(6 citation statements)

References 12 publications

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“…Similar trends were also seen in our previous studies examining the effect of exercise on acute GN [9], This also suggests that the effects of exercise on GN are not benign.…”

Section: Discussionsupporting

confidence: 89%

“…We reported similar results on the effect of exercise on the GN of 'one-shot' serum sickness in rab bits [9], Poststreptococcal GN and the GN o f 'one-shot' serum sickness are alike in that both disorders tend to be self-limited, apparently because of a relatively brief pe riod of glomerular immune complex deposition or for mation. Thus, the failure to observe an effect of exercise on the recovery from acute GN in the clinical and experi mental models of GN previously studied may stem from the fact that the glomerulonephritic process is so short lived that any effect of exercise on the GN is necessarily small.…”

Section: Discussionsupporting

confidence: 58%

“…In addition, 17 (94%) of 18 animals developed abnormal albuminuria, which is a significantly greater frequency (p <0.001) than in our previous study of the GN o f 'one-shot' serum sickness where only 12 (42%) of 28 rabbits developed abnormal albuminuria. Thus, the model of GN used in the present study is more severe than that which we studied previously [9].…”

Section: Discussionmentioning

confidence: 80%

“…Thus, these factors could not explain the significant differences in BUN levels. Plasma creatinine levels were not used as an index of renal function because we showed previously that, in rabbits subjected to exercise as used in this study, serum creatinine levels rise significantly without change in BUN levels [9]. The increase in serum creatinine levels with sustained exercise is, apparently, the result of in creased creatinine production of exercise [13].…”

Section: Resultsmentioning

confidence: 99%

“…Previously, we evaluated the effect of exercise stress on the acute GN of'one-shot' serum sickness and found no significant adverse effects [9]. However, in that model of GN, the immune complexes deposit during a relatively brief period [10], Thus, if exercise can affect the natural history of immune complex-mediated GN it might be difficult to discern such an effect in our previous experi ments because the model of GN used permitted only a limited interaction between the process of immune com plex deposition and the exercise stress.…”

Section: Introductionmentioning

confidence: 99%

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Adverse Effect of Exercise on Immune Complex-Mediated Glomerulonephritis

Cornacoff

Hebert

Sharma

et al. 1985

Nephron

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To assess the effect of strenuous daily exercise on immune complex-mediated glomerulonephritis (GN), rabbits were randomly assigned to one of three experimental groups: Group I (n = 12): treadmill exercise for 28 days plus twice weekly intravenous injections of saline. Group II (n = 10): treadmill exercise for 28 days plus twice weekly intravenous bovine serum albumin (BSA) injection. Group III (n = 9): intravenous doses of BSA, as in group II, but no exercise. Blood and urine samples were collected from each animal periodically during the 28-day experimental period. On the 29th day of the study all animals were sacrificed and tissue taken for renal histopathologic studies. We found that in group II (exercise + GN) abnormal albuminuria was more frequent (p < 0.001), blood urea nitrogen (BUN) levels rose significantly with time (p < 0.02) and hematuria (blood in renal tubules) was more common (p < 0.05), compared to group III (GN only). The differences between groups II and III could not be explained by the effect of exercise alone since group I (exercise only) developed no abnormal abluminuria, BUN levels or hematuria during the course of the study. These findings suggest that strenuous exercise superimposed on active immune complex-mediated GN results in worsening of the abnormal glomerular function.

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“…Similar trends were also seen in our previous studies examining the effect of exercise on acute GN [9], This also suggests that the effects of exercise on GN are not benign.…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Adverse Effect of Exercise on Immune Complex-Mediated Glomerulonephritis

Cornacoff

Hebert

Sharma

et al. 1985

Nephron

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Exercise training ameliorates progressive renal disease in rats with subtotal nephrectomy

Heifets¹,

Davis²,

Tegtmeyer³

et al. 1987

Kidney International

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To determine the effect of chronic exercise training on renal function in animals with moderate renal insufficiency, rats with 75% renal ablation were either exercise trained by swimming for two months or remained sedentary. Glomerular filtration rate was significantly higher in trained (1.89 +/- 0.07 ml/min) than in sedentary rats (1.52 +/- 0.11 ml/min). No change was observed in renal blood flow or the degree of hypertension. Proteinuria was reduced in trained (13.6 +/- 4.9 mg/24 hr) compared to sedentary animals (33.5 +/- 9.2 mg/24 hr). The degree of glomerulosclerosis was much less prominent in trained animals. Plasma, low-density lipoprotein cholesterol-levels and total triglycerides were reduced in trained compared to sedentary rats. This study suggests that chronic exercise training ameliorates the progression of renal disease and improves plasma lipids in rats with moderate renal insufficiency. The mechanism for this improvement in renal function appears to be independent of the influence of systemic blood pressure.

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Loin pain-hematuria syndrome associated with thin glomerular basement membrane disease and hemorrhage into renal tubules

Hebert¹,

Betts²,

Sedmak³

et al. 1996

Kidney International

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Loin pain-hematuria (LPH) syndrome is a poorly understood disorder in which the patients, mainly young women, experience unexplained severe chronic unilateral or bilateral flank pain associated with gross and/or microscopic hematuria. By contrast, thin glomerular basement membrane (GBM) disease is generally thought to be a benign disorder, affecting males and females equally, in which the major manifestation is asymptomatic microscopic hematuria. Herein we describe seven patients (6 females, 1 male) in whom thin GBM appeared to be the cause of the LPH syndrome. The gross hematuria in these patients could be attributed to thin GBM disease because the renal biopsy demonstrated red cells in renal tubules (indicating glomerular hematuria) and the only glomerular abnormality present with thin GBM. In addition, the other causes of gross hematuria were excluded by appropriate testing. The flank pain in these patients might also have been the result of their thin GBM disease. This is suggested by renal biopsy findings of multiple renal tubules filled with red cells, apparently occluding the tubules. We suggest that occlusion of a relatively small fraction of renal tubules could cause renal pain if back-leak of glomerular filtrate occurred that was of sufficient magnitude to expand renal parenchymal volume and stretch the renal capsule. Preliminary observations suggest that treatment with the angiotensin converting enzyme (ACE) inhibitor enalapril importantly reduces the frequency and severity of the episodes of gross hematuria and flank pain in most patients. ACE inhibition might decrease glomerular hemorrhage in patients with think GBM by decreasing glomerular hydrostatic pressure. We conclude that (1) Thin GBM disease can be the cause of gross hematuria, apparently as a result of rupture of thin GBM. (2) Rupture of thin GBM resulting in hemorrhage into renal tubules may be the cause of the flank pain and gross hematuria in some patients with the LPH syndrome.

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Effect of Moderate Daily Exercise on Acute Glomerulonephritis

Cited by 8 publications

References 12 publications

Adverse Effect of Exercise on Immune Complex-Mediated Glomerulonephritis

Adverse Effect of Exercise on Immune Complex-Mediated Glomerulonephritis

Exercise training ameliorates progressive renal disease in rats with subtotal nephrectomy

Loin pain-hematuria syndrome associated with thin glomerular basement membrane disease and hemorrhage into renal tubules

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