Effect of Modulated TENS on Corticospinal Excitability in Healthy Subjects

Jadidi, Armita Faghani; Stevenson, Andrew James Thomas; Zarei, Ali Asghar; Jensen, Winnie; Lontis, Romulus

doi:10.1016/j.neuroscience.2022.01.004

Cited by 12 publications

(20 citation statements)

References 67 publications

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“…With the coil on the hotspot site, the resting motor threshold (RMT) was specified as the minimum TMS intensity required to elicit peak-to-peak MEP larger than 50 µV in at least 5 out of 10 trials [30]. The TMS intensity was set to 120% of the RMT and kept constant for all stimulation sites for the duration of the experiment [31]. Ten MEPs [32] were elicited for each site (hotspot, C3, and F3) and at each assessment point (Pre, Post0, Post30, and Post60) with an interstimulus interval of 5-10 s [9,10].…”

Section: Assessment Protocol 251 Corticospinal Excitability Using Tms...mentioning

confidence: 99%

Effectiveness of motor and prefrontal cortical areas for brain-controlled functional electrical stimulation neuromodulation

Fadli,

Yamanouchi,

Jovanovic

et al. 2023

J. Neural Eng.

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Objective: Brain-computer interface (BCI)-controlled functional electrical stimulation (FES) could excite the central nervous system to enhance upper limb motor recovery. Our current study assessed the effectiveness of motor and prefrontal cortical activity-based BCI-FES to help elucidate the underlying neuromodulation mechanisms of this neurorehabilitation approach.Approach: The primary motor cortex (M1) and prefrontal cortex (PFC) BCI-FES interventions were performed for 25 min on separate days with twelve non-disabled participants. During the interventions, a single electrode from the contralateral M1 or PFC was used to detect event-related desynchronization (ERD) in the calibrated frequency range. If the BCI system detected ERD within 15 s of motor imagery, FES activated wrist extensor muscles. Otherwise, if the BCI system did not detect ERD within 15 s, a subsequent trial was initiated without FES. To evaluate neuromodulation effects, corticospinal excitability was assessed using single-pulse transcranial magnetic stimulation, and cortical excitability was assessed by motor imagery ERD and resting-state functional connectivity before, immediately, 30 min, and 60 min after each intervention.Main results: M1 and PFC BCI-FES interventions had similar success rates of approximately 80%, while the M1 intervention was faster in detecting ERD activity. Consequently, only the M1 intervention effectively elicited corticospinal excitability changes for at least 60 min around the targeted cortical area in the M1, suggesting a degree of spatial localization. However, cortical excitability measures did not indicate changes after either M1 or PFC BCI-FES.Significance: Neural mechanisms underlying the effectiveness of BCI-FES neuromodulation may be attributed to the M1 direct corticospinal projections and/or the closer timing between ERD detection and FES, which likely enhanced Hebbian-like plasticity by synchronizing cortical activation detected by the BCI system with the sensory nerve activation and movement related reafference elicited by FES.

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Section: Assessment Protocol 251 Corticospinal Excitability Using Tms...mentioning

confidence: 99%

Effectiveness of motor and prefrontal cortical areas for brain-controlled functional electrical stimulation neuromodulation

Fadli,

Yamanouchi,

Jovanovic

et al. 2023

J. Neural Eng.

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“…Depending on TENS characteristics (including intensity, frequency, duration, and application site), the underlying mechanism and respective therapeutic effect of the treatment may differ (L. S. Lucy S. Chipchase et al, 2011;Faghani Jadidi et al, 2022;Jadidi et al, 2020;Mang et al, 2010;Peng et al, 2019). For pain alleviation, TENS parameters generally are divided into the following categories.…”

Section: Transcutaneous Electrical Stimulationmentioning

confidence: 99%

“…Subjects received the intervention through pair of oval electrodes (Dura Stick, 4 x 6 cm) for 30 min on their right median nerve with 20 s on 10 s off repetition (Lagerquist et al, 2012;Mang et al, 2010). The intensity of each intervention was individually adjusted at 80 % of the discomfort threshold (measured by staircase procedure) to induce a strong but comfortable sensation (Faghani Jadidi et al, 2022;Manresa et al, 2018;A. A. Zarei et al, 2021).…”

Section: Tensmentioning

confidence: 99%

“…In total, 100 single sensory pulses (with 500 µs pulse width) were delivered to the median nerve of two hands alternately through the surface electrodes. The intensity of stimulation was set 2.5 times the sensory threshold measured at the beginning of the experiment using the stare case procedure (Faghani Jadidi et al, 2022;A. A. Zarei et al, 2021).…”

Section: Data Recordingmentioning

confidence: 99%

“…Three highly suggested features in pain literature, including map volume, the number of active sites, and coordinate of the center of gravity (CoG) were extracted at Pre ad Post. More detail are explained in (Faghani Jadidi et al, 2022).…”

Section: Data Analysis Study Imentioning

confidence: 99%

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Towards Understanding the Neurobiological Effects of Modulated Tens

Jadidi¹

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