Effect of modulators of the polyamine site on the development of seizures induced by systemic and intracerebral administration of N-methyl-D-aspartate in albino mice

Efremov, O. M.; Serdyuk, S. E.; Гмиро, В. Е.

doi:10.1007/s10517-007-0198-4

Cited by 1 publication

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data indicate that the decrease in BBB permeability to the polar compound induced by a polyamine antagonist arcaine [1] was not followed by significant reduction in BBB permeability to lipophilic nicotine. As differentiated from polar compound NMDA, nicotine easily crosses BBB.…”

Section: Resultsmentioning

confidence: 73%

“…By contrast, administration of polyamine antagonist arcaine prevents seizures induced by intraperitoneal injection of NMDA. The observed effects are associated with opposite changes in BBB permeability to NMDA, which results from modulation of the NMDA receptor polyamine site in BBB cells [1].…”

Section: Resultsmentioning

confidence: 96%

“…Our previous studies showed that IEM-1460 has properties of a GluR1 AMPA receptor antagonist and NMDA receptor polyamine site agonist [1]. Systemic intraperitoneal administration of polyamine agonist IEM-1460 potentiates the development of seizures induced by intraperitoneal injection of NMDA.…”

Section: Resultsmentioning

confidence: 99%

“…Competitive antagonism exists between the test substances at the NMDA receptor polyamine site in BBB cells [1].…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice

2008

Self Cite

View full text Add to dashboard Cite

Peripheral administration of nicotinic receptor antagonists with a quaternary ammonium group (hexamethonium and chlorisondamine) did not prevent the development of seizures induced by systemic treatment with nicotine in the toxic dose. The Me3N+ group with stable positive charge inhibits transport of these compounds into the brain through the blood-brain barrier. Intracerebral and peripheral (intraperitoneal) administration of compound IEM-1460 with the Me3N+ group was equally potent in reducing the severity of nicotine-induced seizures in mice. This phenomenon is related to the fact that IEM-1460 acts as a nicotinic receptor antagonist and polyamine agonist, which increases blood-brain barrier permeability for polar compounds. These features contribute to IEM-1460 transport into the brain. High anticonvulsant activity of IEM-1460 on the model of nicotine-induced seizures is associated with combined blockade of nicotinic receptors (alpha3beta4 receptors) and glutamate receptors (GluR1 AMPA receptors).

show abstract

Section: Resultsmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

“…Competitive antagonism exists between the test substances at the NMDA receptor polyamine site in BBB cells [1].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations