Effect of molecular weight of hyaluronan on zein-based nanoparticles: Fabrication, structural characterization and delivery of curcumin

Chen, Shuai; Han, Yahong; Sun, Cuixia; Dai, Lei; Yang, Shufang; Yang, Wei; Mao, Like; Yuan, Fang; Gao, Yanxiang

doi:10.1016/j.carbpol.2018.08.116

Cited by 118 publications

(64 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[14][15][16] Attractive designs of delivery systems for curcumin have been rapidly developed in this area including the use of zein-hyaluronan-based nanoparticles. 17,18 Among the above-mentioned delivery systems, polymeric micelles have recently attracted much attention in overcoming solubility-related problems of curcumin. 14,19 Polymeric micelles, most of them are surfactants, consist of amphiphilic block copolymers that spontaneously assembled into nano-sized structures in aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery

Wijiani¹,

Isadiartuti²,

Rijal³

et al. 2020

IJN

View full text Add to dashboard Cite

Introduction: Curcumin faces a major challenge in clinical use due to its poor aqueous solubility, which affects its bioavailability over oral use. The present study was carried out to overcome this problem. Methods: An amorphous micellar curcumin-spray dried powder (MC-SDP) with selfassembled casein was prepared by the addition of sucrose as a protectant. The dry powder of curcumin-loaded micelles was obtained by a spray-drying technique in the presence of sucrose as a protectant. The MC-SDP in the form of dry powder was further developed into tablets to investigate the dissolution profile. The physical properties of preformed powder were characterized by differential thermal analysis (DTA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Quantitative analysis in the form of solutions was analyzed by high-performance liquid chromatography (HPLC). Results: The physical properties demonstrated that MC-SDP varies from dented to smoother surfaces as a function of sucrose. Furthermore, melting transitions of curcumin in the form of MC-SDP were broadened in all sample mixtures, as observed in the DTA thermogram. The XRD spectra showed that the sharp and very intense peaks of single curcumin crystalline structure no longer existed in all MC-SDP forms, indicating that the mixtures were amorphous. Moreover, a further dissolution study of MC-SDP showed a significant increase of drug dissolved with the presence of sucrose, where >80% of curcumin from MC-SDP was dissolved within 30 min. Conclusion: The study demonstrated the manufacture of micellar spray-dried powder that would contribute to the development of oral delivery of curcumin.

show abstract

Section: Introductionmentioning

confidence: 99%

Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery

Wijiani¹,

Isadiartuti²,

Rijal³

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…According to a study, it has been proven that curcumin can be loaded in zein-based NPs [ 91 ]. The study has presented zein-hyaluronan NPs, and the results have shown high stability and a controlled release system in gastrointestinal simulation [ 95 ]. There were multiple studies carried out by using zein in combination with various reagents.…”

Section: Curcumin-loaded Colloidal Delivery Systemsmentioning

confidence: 99%

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

et al. 2020

View full text Add to dashboard Cite

This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.

show abstract

“…93 A novel curcumin nanodelivery system with high encapsulation efficiency, loading capacity and better stability, are zein-hyaluronic acid (HA) NPs (ZH-NPs). 94 Other nutraceuticals carried by NPs were tested and gave successful preliminary results, among them berberine decorating multi-walled carbon nanotubes, 95 α-bisabolol SLNs, 96 apocynin polyanhydride NPs, 97 ginsenoside Rg3-, 98 phytol-, 99 epigallocatechin-3-gallate-, 100 and rhynchophylline-loaded 101 PLGA NPs.…”

Section: Nutraceutical Loaded Nps and Green Npsmentioning

confidence: 99%

Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer’s Disease: A State-of-the-Art (2017–2020)

Binda¹,

Murano²,

Rivolta³

2020

IJN

View full text Add to dashboard Cite

The field of nanomedicine is constantly expanding. Since the first work dated in 1999, almost 28 thousand articles have been published, and more and more are published every year: just think that only in the last five years 20,855 have come out (source PUBMED) including original research and reviews. The goal of this review is to present the current knowledge about nanomedicine in Alzheimer's disease, a widespread neurodegenerative disorder in the over 60 population that deeply affects memory and cognition. Thus, after a brief introduction on the pathology and on the state-of-the-art research for NPs passing the BBB, special attention is placed to new targets that can enter the interest of nanoparticle designers and to new promising therapies. The authors performed a literature review limited to the last three years (2017-2020) of available studies with the intention to present only novel formulations or approaches where at least in vitro studies have been performed. This choice was made because, while limiting the sector to nanotechnology applied to Alzheimer, an organic census of all the relevant news is difficult to obtain.

show abstract

Effect of molecular weight of hyaluronan on zein-based nanoparticles: Fabrication, structural characterization and delivery of curcumin

Cited by 118 publications

References 44 publications

<p>Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery</p>

<p>Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery</p>

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

<p>Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer’s Disease: A State-of-the-Art (2017–2020)</p>

Contact Info

Product

Resources

About