Effect of Momordica charantia L. on serum biochemical parameters in experimentally induced atypical acinar cell tumors in male wistar rats

Abstract

The present investigation was carried out to study the effect of Momordica charantia L. (Bitter gourd) on serum biochemical parameters in male wistar rats induced with pancreatic atypical acinar cell tumor. Ninety six male wistar rats were randomized into four groups [control group, (i), azaserine group (ii), azaserine + paclitaxel (iii) and azaserine + Momordica charantia (MC) (iv) group] each comprising of 24 rats. Male wistar rats of group (ii, iii and iv) were administered with azaserine @ 30 mg per kg BW intraperitoneally (i.p.) on 21 st day of age. Paclitaxel was administered to the azaserine + paclitaxel group (iii) @ 33 mg/kg BW intraperitoneally for 6 weeks after 8 weeks post initiation of tumor and aqueous extract of Momordica charantia @ 0.34 ml/rat was administered as oral gavage for 6 weeks after 8 weeks post initiation of tumor to azaserine + Momordica charantia group (iii). The blood was collected for estimation of serum biochemical parameters at the end of 24 th week. Significant alterations in ALT, ALP, triglyceride, cholesterol, lipase and amylase levels were observed among the groups ii, iii and iv. The alterations were compared with the control and azaserine + paclitaxel group which revealed the high level of protective effect of aqueous extract of Momordica charantia, on the serum biochemical alterations.