Effect of Monoclonal Antibody to Human Zone Pellucida 3 on Bone Morphogenetic Protein 15 Expression and Number of Preantral and Antral Follicles in Ovary of Mice

Abstract

Introduction: Immunocontraception of zone pellucide (ZP3) is known causing disturbance of gap junction which inhibits transport growth factor such as bone morphogenetic protein (BMP-15). Decreased BMP-15 generates disturbance of proliferation and differentiation of follicle, granulosa, and techa cells. Anti-Human ZP3 monoclonal antibody with high specificity is being developed to prevent such effects. This study aimed to evaluate the effect of MabhZP3 on the expression of BMP-15 and number of preantral and antral follicles in the ovary of mice.