Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

Shosha, Hadeer M; Ebaid, Hala M.; Toraih, Eman A.; Abdelrazek, Heba M. A.; Elrayess, Ranwa A.

doi:10.1007/s11356-023-25661-x

Cited by 13 publications

(4 citation statements)

References 86 publications

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“…Progesterone has an essential role in maintaining pregnancy. 20 If the hormone progesterone is insufficient, it will cause continuous uterine contractions, leading to embryo implantation failure and abortion. 21 The hormone estrogen plays a role in maintaining the corpus luteum to keep secreting progesterone.…”

Section: Resultsmentioning

confidence: 99%

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

2023

TJNPR

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Sungkai leaf (Peronema canescens Jack.) is a natural source of flavonoids. Flavonoids have been implicated in increasing fertility in humans. This study aims to determine the effect of oral ethanol extract of Sungkai leaf on the fertility of female mice. Twenty-four female mice randomly divided into four groups were used in this study. The test (II-IV) groups were administered orally ethanol leaf extract of Peronema canescens at doses of 200 mg/kg bw, 400 mg/kg bw, and 800 mg/kg bw, respectively, for 14 days. The negative control (I) group received 0.5% Na-CMC only. On the 15th day, the mice were mated with male mice in one cage until pregnancy was established. On the 10th day of gestation, the mice were sacrificed by cervical dislocation, and both ovaries were excised. The result shows increased primary ovarian follicles, corpus luteum, and ovulation rate. The optimal increase of the ovaries occurred at the dose of 200 mg/kg bw. There was however a decrease in the above parameters at extract doses of 400 and 800 200 mg/kg bw. The study concludes that the leaf extract of Peronema canescens has the potential to treat infertility.

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Section: Resultsmentioning

confidence: 99%

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

2023

TJNPR

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“…In recent years, the safety and toxicity of MSG have become controversial due to reports of adverse responses in individuals who have consumed MSG-containing foods. Numerous studies have confirmed the harmful effects of MSG [9]. MSG has been linked to headaches, nausea, diarrhea, irritable bowel syndrome, asthma symptoms in asthmatic patients, and panic attacks [10].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Chemical Composition of Lepidium sativum Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction

El-Gendy,

El-Gezawy,

Saleh

et al. 2023

Foods

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Monosodium glutamate (MSG) is one of the most frequently used food additives that endanger public health. The antioxidant, hyperlipidemic, and cytoprotective properties of Lepidium sativum seeds (LSS) as a natural remedy can minimize the harmful effects of MSG. This study investigated the potential protective effect of LSS against MSG-induced hepatotoxicity in rats. Male albino Sprague Dawley rats (n = 24) were equally divided into four groups for 30 days: the control group (G1) received a basal diet without supplement, group (G2) was fed a basal diet + MSG (30 g/kg b.w.) as a model group, group (G3) was fed a basal diet + MSG (30 g/kg b.w.) + LSS (30 g/kg b.w.), and group (G4) was fed a basal diet + MSG (30 g/kg b.w.) + LSS (60 g/kg b.w.). LSS enhanced serum alkaline phosphatase activity as well as total cholesterol, triglyceride, and glucose levels. It can decrease peroxide content in serum lipids and inhibit glutathione reductase and superoxide dismutase in hepatic cells. The dietary supplementation with LSS provided cytoprotection by enhancing the histoarchitecture of the liver and decreasing the number of apoptotic cells. Due to their antioxidant and anti-apoptotic properties, LSS effectively protect against the hepatotoxicity of MSG. These findings are of the highest significance for drawing attention to incorporating LSS in our food industry and as a health treatment in traditional medicine to combat MSG-induced hepatic abnormalities.

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“…Mondal et al ( Mondal et al, 2017 ) reported that MSG suppresses the female reproductive function by impairing the functions of ovary and uterus. Also, MSG during pregnancy adversely influences fetal growth and skeletal development causing several biochemical and histological changes to the maternal and fetal liver and kidney tissues ( Shosha et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Disruptive consequences of monosodium glutamate on male reproductive function: A review

OLUWOLE,

EBIWONJUMI,

AJAYI

et al. 2024

Current Research in Toxicology

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Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

Cited by 13 publications

References 86 publications

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

Investigating the Chemical Composition of Lepidium sativum Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction

Disruptive consequences of monosodium glutamate on male reproductive function: A review

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