Effect of Monthly and Bi-Monthly 50,000 International Units (IU) Maintenance Therapy With Vitamin D3 on Serum Level of 25-Hydroxyvitamin D in Adults: A Randomized Controlled Trial

Abstract

Background Vitamin D deficiency is a prevalent condition worldwide. Identification of optimal supplementation approaches for maintaining normal vitamin D level in healthy adults is still required. It has been clearly established that sun exposure and diet do not provide the recommended daily amount of vitamin D, and that vitamin D supplementation is needed to maintain normal levels in the Saudi population. The aim of this study was to compare the efficacy of two regimens, monthly and bimonthly doses of 50,000 International Units (IU) cholecalciferol (vitamin D3), in maintaining normal serum levels of 25-hydroxyvitamin D in Saudi adults. Methods This study was a randomized controlled trial conducted to compare the efficacy of three regimens in maintaining a normal level of vitamin D in adult individuals. The study took place at three primary healthcare centers in King Abdul-Aziz Medical City, Riyadh, Saudi Arabia. A total of 65 participants were enrolled and randomly divided into two intervention groups and one control group. All participants were contacted by researchers and followed up at their corresponding primary health care center for two successive visits. Results All 65 participants completed the study. The participants were mostly females (49; 75.4%); the mean age was 42.1 years (±13.5). The difference in vitamin D levels after three months of the trial was statistically significant among the three groups. A decrease in vitamin D level was recorded in the control group and in the once monthly intake of 50,000 IU group. The bimonthly intake of 50,000 IU group maintained statistically significant vitamin D levels > 75. Conclusion Bimonthly vitamin D3 supplementation appears to be an efficient regimen for maintaining a normal level of 25(OH)D, regardless of the amount of vitamin D obtained from diet and sun exposure.

Determining the vitamin D supplementation duration to reach an adequate or optimal vitamin D status and its effect on blood lipid profiles: a longitudinal study

“…In several studies the effect of different durations of supplementation with 50,000 IU Vit. D has been investigated on different health outcomes [ 20 – 23 , 28 ]. In a study by Penckofer et al has shown that supplementation with 50,000 IU weekly for 6 months increased the serum Vit.…”

“…In several studies the effect of different durations of supplementation with 50,000 IU Vit. D has been studied with different health outcomes [ 20 – 23 ]. However determining the Vit.…”

COVID-19 exposure and depression-anxiety levels among Saudi adults in the Jazan region: a study with a predominantly female and undergraduate sample

“…Additionally, research has indicated that the swift dissemination of COVID-19 within Saudi Arabia (KSA) has been associated with an upsurge in psychological symptoms among various segments of the population. These symptoms encompass stress, affective symptoms, insomnia, and obsessive-compulsive symptoms (33)(34)(35)(36)(37)(38)(39)(40)(41)(42).…”

“…Nevertheless, the majority of the conducted studies in Saudi Arabia have taken place during the pandemic and lockdown periods, providing valuable insights into various aspects of the situation (33,34,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45).…”

Proliferative gynecological diseases and vitamin D deficiency: a look at the problem

“…Схемы лечения дефицита и недостаточности витамина D. Коррекция дефицита витамина D (уровень 25(OH)D менее 20 нг/мл)  50 000 МЕ еженедельно в течение 8 недель внутрь  200 000 МЕ ежемесячно в течение 2 месяцев внутрь  150 000 МЕ ежемесячно в течение 3 месяцев внутрь  6000 -8000 МЕ в день -8 Продолжительность поддерживающей терапии и эффективная поддерживающая терапия для взрослых с целевым достигнутым или исходным уровнем витамина D четко не определены. Прием 50 000 МЕ витамина D каждые 2 недели (что эквивалентно 3500 МЕ в сутки) показал эффективность в поддержании уровня 25(OH)D в целевом диапазоне выше 30 нг/мл и отсутствие значимых побочных эффектов при наблюдении до 6 лет[90,91]. Суточной дозы в 2000 МЕ, по данным ряда исследований, может оказаться недостаточно для достижения таких показателей[92,93], но в некоторых исследованиях оказались эффективными и более низкие дозы (900 -1800 МЕ в сутки)[94], что подтверждается опытом отечественных экспертов.…”