Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial

Slow, Sandy; Florkowski, Christopher M; Chambers, Stephen T.; Priest, Patricia; Stewart, Alistair; Jennings, Lance C.; Livesey, J. H.; Camargo, Carlos A.; Scragg, Robert; Murdoch, David R.

doi:10.1136/bmj.g7260

Cited by 7 publications

(9 citation statements)

References 24 publications

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“…This should be followed by a repeat test of vitamin D and a bone profile in 3‐6 months to ensure adequate treatment efficacy. Adverse effects are uncommon 23 ; hence, the importance of our findings.…”

Section: Discussionmentioning

confidence: 71%

Detectable respiratory SARS‐CoV‐2 RNA is associated with low vitamin D levels and high social deprivation

et al. 2021

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Background: Accumulating evidence links COVID-19 incidence and outcomes with vitamin D status. We investigated if an interaction existed between vitamin D levels and social deprivation in those with and without COVID-19 infection. Methods: Upper or lower respiratory tract samples from 104 patients were tested for SARS-CoV-2 RNA in accordance with Public Health England criteria (January-May 2020) using RT-PCR. The latest serum total 25-hydroxyvitamin D(25-OHD) levels, quantified by LC-MS/MS, was obtained for each patient (September 2019-April 2020). Index of Multiple Deprivation (IMD) was generated for each patient. Univariate and logistic regression analyses examined associations between age, gender, 25-OHD, IMD score and SARS-CoV-2 result in the total cohort and subgroups. Results: In the total cohort, a positive SARS-CoV-2 test was significantly associated with lower 25-OHD levels and higher IMD. A positive test was associated with higher IMD in the male subgroup and with lower 25-OHD levels in those aged >72 years. Low 25-OHD and IMD quintile 5 were separately associated with positive COVID-19 outcome in the cohort. Patients in IMD quintile 5 with vitamin D levels ≤ 34.4 nmol/L were most likely to have a positive COVID-19 outcome, even more so if aged

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Section: Discussionmentioning

confidence: 71%

Detectable respiratory SARS‐CoV‐2 RNA is associated with low vitamin D levels and high social deprivation

et al. 2021

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“…Out of the 19,051 screened records, 19 studies were included in this systematic review. Out of these studies, thirteen were RCTs [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ], one was an opportunistic addition to an established randomized, double-blind, placebo-controlled trial [ 37 ], four were pre–post studies [ 38 , 39 , 40 , 41 ], and one was a self-controlled before–after trial, analyzed retrospectively as a case series [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 demonstrates the characteristics of the included studies. Six of the studies were conducted in Iran [ 25 , 27 , 30 , 31 , 34 , 39 ], five in the USA [ 28 , 29 , 32 , 33 , 42 ], one in Ireland [ 26 ], one in New Zealand [ 37 ], one in KSA [ 35 ], one in China [ 36 ], one in Turkey [ 40 ], and one in the Netherlands [ 24 ]. The number of participants varied from 5 [ 31 ] to 18,353 [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…In the majority of the studies, the intervention consisted of vitamin D3 supplementation [ 24 , 26 , 27 , 28 , 29 , 32 , 33 , 34 , 35 , 37 , 38 , 42 ], two used vitamin D2 supplementation [ 40 , 42 ], and the form of vitamin D was unclear in six trials [ 25 , 30 , 31 , 36 , 39 , 41 ]. Only Sharifan et al [ 34 ] assessed VDS in the form of fortified low-fat milk or low-fat yogurt.…”

Section: Resultsmentioning

confidence: 99%

“…When reported, compliance with VDS was high in all studies. The majority of the studies were placebo controlled [ 24 , 25 , 26 , 27 , 28 , 30 , 31 , 32 , 35 , 36 , 37 ]. In two studies, the comparator was no supplementation [ 29 , 39 ]; in one study, it was a lower dose of vitamin D [ 33 ]; in one study, it was either low-fat milk or yogurt [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

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Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

Abboud

2022

Nutrients

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Background: Vitamin D deficiency is associated with sleep disorders and poor sleep quality. Whether vitamin D supplementation (VDS) helps resolve these problems remains unclear. Objective: To systematically review the effect of VDS on sleep quantity, quality, and disorders, and perform a meta-analysis of available data. Methods: The reporting of this review followed the PRISMA statement. VDS human interventions studies that reported on sleep quality, quantity, or disorders were included. Medline, CINAHL, EMBASE, PsycInfo, the Cochrane Library, Clinicaltrials.gov, and the ICTRP were searched, in addition to the references of the included articles and previous relevant reviews, without language or time restrictions. Included studies were critically appraised, findings were narratively synthesized, and a meta-analysis was conducted. Furthermore, the overall certainty of the evidence was assessed. Results: A total of 19 studies were included (13 randomized controlled trials (RCTs), 1 opportunistic addition to an RCT, 4 pre–post studies, and 1 pre–post study analyzed as a case series); 3 RCTs were meta-analyses. The risk of bias was generally low. Pre–post studies showed a significant improvement in sleep quality with VDS. Similarly, the results of the meta-analysis revealed a statistically significant decrease in the Pittsburgh Sleep Quality Index with VDS compared with placebo (mean difference, −2.33 (95% CI, −3.09, −1.57); p < 0.001; I2 = 0%), with a moderate certainty of evidence. The results regarding the effect of VDS on sleep-related impairment, difficulty, and disorders, as well as sleepiness and restless legs syndrome, were not unanimous. Conclusions: VDS is promising in improving sleep quality; however, its effect on sleep quantity and disorders needs to be further investigated.

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Generalized Anxiety: Linking in Vitamin D

Angelopoulos,

Angelopoulou,

Karras

2024

Handbook of the Biology and Pathology of Mental Disorders

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Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial

Abstract: Objective To determine whether supplementation with vitamin D improves resilience to the adverse effects of earthquakes.

Cited by 7 publications

References 24 publications

Detectable respiratory SARS‐CoV‐2 RNA is associated with low vitamin D levels and high social deprivation

Detectable respiratory SARS‐CoV‐2 RNA is associated with low vitamin D levels and high social deprivation

Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies

Generalized Anxiety: Linking in Vitamin D

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